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These brands contain the same active ingredient (Topiramate). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Topirva
Other strengths and forms by Incepta Pharmaceuticals Ltd.
Indications & Uses
Pharmacology
A seizure is an abnormal, unregulated electrical discharge in the brain. This causes a brief interruption in brain function, showing up as reduced alertness, unusual sensations, and focal involuntary movements or convulsions. Several types of seizures exist, with tonic-clonic seizures and partial onset seizures being among the most common.
The exact mechanisms by which topiramate acts against seizures and migraines are not yet fully understood. However, several properties of the drug are thought to contribute to its therapeutic effects. Topiramate has been observed to act on voltage-dependent sodium channels, GABA receptors, and glutamate receptors.
It stimulates GABA-A receptor activity at non-benzodiazepine sites in the brain and reduces glutamate activity at both AMPA and kainate receptors. GABA-A receptors are normally inhibitory, while glutamatergic receptors are normally stimulatory for neuronal activity. By increasing GABA activity and reducing glutamate activity, topiramate curbs neuronal excitability, helping to prevent seizures and migraines. It also blocks voltage-dependent sodium channels, further reducing seizure activity. Topiramate has also been shown to inhibit various carbonic anhydrase isozymes, though the clinical significance of this effect is not yet known.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Epilepsy, monotherapy, adults and children over 16 years: Titration should begin at 25 mg nightly for 1 week. The dosage should then be increased at 1 or 2 week intervals by increments of 25 or 59 mg/day, given in two divided doses. The recommended initial target dose for topiramate monotherapy in adults with newly diagnosed epilepsy is 100 mg/day, and the maximum recommended daily dose is 400 mg.
Children aged 6 to 16 years: Treatment of children aged 6 years and above should begin at 0.5 to 1 mg/kg nightly for the first week. The dosage should then be increased at 1 or 2 week intervals by increments of 0.5 to 1 mg/kg/day, given in two divided doses. The recommended initial target dose range for topiramate monotherapy in children with newly diagnosed epilepsy aged 6 years and above is 3 to 6 mg/kg/day. Higher doses have been tolerated, and rarely doses up to 16 mg/kg/day have been given.
Epilepsy, adjunctive therapy, adults and children over 16 years: The minimal effective dose as adjunctive therapy is 200 mg per day. The usual total daily dose is 200 mg to 400 mg in two divided doses. Some patients may require doses up to 800 mg per day, which is the maximum recommended dose.
Children aged 2 to 16 years: The recommended total daily dose of topiramate as adjunctive therapy is approximately 5 to 9 mg/kg/day in two divided doses. Titration should begin at 25 mg nightly for the first week. The dosage should then be increased at 1 or 2 week intervals by increments of 1 to 3 mg/kg/day, given in two divided doses, to achieve optimal clinical response. Dose titration should be guided by clinical outcome. Daily doses up to 30 mg/kg/day have been studied and were generally well tolerated.
Migraine, adults and children over 16 years: Titration should begin at 25 mg nightly for 1 week. The dosage should then be increased in increments of 25 mg/day, administered at 1 week intervals. The recommended total daily dose of topiramate for the prophylaxis of migraine headache is 100 mg/day, given in two divided doses. Some patients may experience benefit at a total daily dose of 50 mg/day.
Children: Topiramate for migraine prophylaxis has not been studied in children under 16 years.
Side Effects
Topiramate can cause nausea, abdominal pain, dyspepsia, diarrhoea, dry mouth, taste disturbance, weight loss and anorexia. Other effects people may notice are paraesthesia, hypoaesthesia, headache, fatigue, dizziness, speech disorder, drowsiness and insomnia. Impaired memory and concentration, anxiety, depression and visual disturbance have also been reported. Less commonly, suicidal ideation can occur. Rarely, topiramate causes reduced sweating (mainly in children), metabolic acidosis and alopecia. Very rarely, leucopenia, thrombocytopenia and serious skin reactions are seen.
Cautions & Contraindications
Warnings & Precautions
In patients with or without a history of seizures or epilepsy, antiepileptic drugs, including Topirva XR, should be gradually withdrawn to minimize the potential for seizures or increased seizure frequency. Topirva XR can produce central nervous system related adverse events and may be more sedative than other antiepileptic drugs. Drowsiness is a likelihood. In addition, there have been reports of visual disturbances and blurred vision. Patients should be warned of these effects and advised that if affected, they should not drive, operate machinery, or take part in activities where such reactions could put themselves or others at risk.
Contraindications
Hypersensitivity to topiramate or to any other ingredient in this product.
Pregnancy & Breastfeeding
Topiramate is generally avoided in pregnancy, and it should only be used if your physician judges that the benefit to you clearly outweighs the possible risk to your unborn baby. Breastfeeding is not recommended while taking topiramate.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Topiramate overdose can cause severe metabolic acidosis. If someone has taken a large amount of Topiramate recently, the stomach should be emptied straight away, either by lavage or by inducing vomiting. Activated charcoal has been shown to adsorb Topiramate in vitro. Treatment should be supportive, as appropriate for the patient. Haemodialysis has been shown to remove Topiramate from the body effectively. The patient should also be kept well hydrated.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Topiramate below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Topirva 25 mg
What is Topirva 25 mg Tablet?
Topirva 25 mg Tablet is a medicine that contains Topiramate. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Adjunct anti-epileptic drugs group of medicines.
What is Topirva used for?
Topirva is used for: Migraine, Epilepsy, Headache.
What are the side effects of Topirva?
Topiramate can cause nausea, abdominal pain, dyspepsia, diarrhoea, dry mouth, taste disturbance, weight loss and anorexia. Other effects people may notice are paraesthesia, hypoaesthesia, headache, fatigue, dizziness, speech disorder, drowsiness and insomnia.
Can I take Topirva during pregnancy or while breastfeeding?
Topiramate is generally avoided in pregnancy, and it should only be used if your physician judges that the benefit to you clearly outweighs the possible risk to your unborn baby. Breastfeeding is not recommended while taking topiramate. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Topirva?
Topiramate overdose can cause severe metabolic acidosis. If someone has taken a large amount of Topiramate recently, the stomach should be emptied straight away, either by lavage or by inducing vomiting. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Topirva?
Store Topiramate below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Topirva?
Some medicines can interact with Topiramate, for example: Linagliptin + Metformin Hydrochloride, Phenytoin Sodium, Pioglitazone, Hydrochlorothiazide, Glibenclamide, Valproic Acid. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Topmate by Renata PLC has the same ingredient and strength for ৳4.00 per unit, compared with ৳5.00 for Topirva. Ask your doctor or pharmacist before switching.
Do I need a prescription for Topirva?
Topirva is a prescription (Rx) medicine. Take it as your doctor advises.