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Indications & Uses
Topicazole is indicated for:
Pharmacology
Pharmacodynamics: Miconazole is active against the common dermatophytes and yeasts, and also shows antibacterial activity against certain gram-positive bacilli and cocci. It works by inhibiting a demethylation step in the biosynthesis of ergosterol, the end-product of this pathway and the main sterol found in fungal cell membranes. By blocking ergosterol production, miconazole disrupts the fungal cell membrane, causing holes to form in it. Through these holes, essential cell constituents leak out, and the fungal cells eventually die.
Pharmacokinetics: Miconazole has low oral bioavailability (25-30%), as little of it is absorbed from the intestinal tract; however, it is absorbed systemically when given as an oral gel. Once absorbed, it binds extensively to plasma proteins (88.2%), mainly serum albumin, and to red blood cells (10.6%). Most of the absorbed drug is metabolized, with less than 1% excreted unchanged in the urine. Its terminal plasma half-life is 20-25 hours in most patients, and this elimination half-life remains similar in patients with impaired renal function.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Miconazole Oral Gel
For oropharyngeal candidosis in infants aged 4 to 24 months, apply 1.25 ml of gel (1⁄4 measuring spoon) 4 times a day after meals. For adults and children aged 2 years and older, apply 2.5 ml of gel (1⁄2 measuring spoon) 4 times a day after meals.
For gastrointestinal tract candidosis, the dose for infants (4 months of age or above), children and adults who have difficulty swallowing tablets is 20 mg per kg body weight per day, given in four divided doses. The daily dose should not go above 250 mg (10 ml gel) four times daily.
Missed dose: Apply it as soon as you remember. If it is nearly time for the next dose, leave out the missed one and carry on with your usual course.
Miconazole Cream
Apply enough Miconazole Cream to cover the affected areas twice daily (morning and evening) in patients with tinea pedis, tinea cruris, tinea corporis and cutaneous candidiasis. In patients with tinea versicolor, apply it once daily. In intertriginous areas, use it sparingly and smooth it in well, so that maceration is avoided.
Most patients get early relief of symptoms within 2 to 3 days, and clinical improvement may be seen fairly soon after treatment begins. All lesions usually disappear after 2 to 5 weeks.
Treatment should be prolonged for 10 days to prevent relapse. Candida infections, tinea cruris and tinea corporis should be treated for two weeks, and tinea pedis for one month, to reduce the chance of recurrence.
Side Effects
Occasionally, patients may experience nausea and vomiting; diarrhoea can occur with prolonged use, and allergic reactions are seen rarely.
Cautions & Contraindications
Warnings & Precautions
Micofun should be used cautiously alongside anticoagulants, as their effect may need closer monitoring and dose adjustment. Phenytoin plasma levels should likewise be monitored when the two are taken together. When using the gel in infants and young children, care should be taken to avoid applying it in a way that could obstruct the throat.
Contraindications
Miconazole should not be used by anyone who is known to be hypersensitive (allergic) to it.
Pregnancy & Breastfeeding
Miconazole oral gel has not been studied for safety during pregnancy, so it should be avoided if at all possible; where use is being considered, the potential risks need to be weighed against the expected benefit. Because many medicines pass into breast milk, Miconazole should be used with caution in nursing mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Accidental overdose of Miconazole Nitrate may cause vomiting and diarrhea. Treatment is symptomatic and supportive, and there is no specific antidote.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Miconazole Nitrate in a dry place, away from light and heat. Keep it out of the reach of children.
Drug Interactions
Common questions about Topicazole 2%
What is Topicazole 2% Cream?
Topicazole 2% Cream is a medicine that contains Miconazole Nitrate. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Aural Anti-fungal preparations group of medicines.
What is Topicazole used for?
Topicazole is used for: Fungal Infection.
What are the side effects of Topicazole?
Occasionally, patients may experience nausea and vomiting; diarrhoea can occur with prolonged use, and allergic reactions are seen rarely.
Can I take Topicazole during pregnancy or while breastfeeding?
Miconazole oral gel has not been studied for safety during pregnancy, so it should be avoided if at all possible; where use is being considered, the potential risks need to be weighed against the expected benefit. Because many medicines pass into breast milk, Miconazole should be used with caution in nursing mothers. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Topicazole?
Accidental overdose of Miconazole Nitrate may cause vomiting and diarrhea. Treatment is symptomatic and supportive, and there is no specific antidote. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Topicazole?
Store Miconazole Nitrate in a dry place, away from light and heat. Keep it out of the reach of children.
Can I take other medicines with Topicazole?
Some medicines can interact with Miconazole Nitrate, for example: Terfenadine, Cyclosporine, Phenytoin. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Topicazole?
Topicazole is a prescription (Rx) medicine. Take it as your doctor advises.