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Other brands with the same active ingredient
These brands contain the same active ingredient (Tolterodine Tartrate). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Detrusin LA is indicated for treating an overactive bladder, with symptoms such as urge urinary incontinence, urgency, and frequency.
Pharmacology
Tolterodine works by selectively blocking muscarinic receptors in the bladder wall. Non-clinical studies have shown that its action targets the urinary bladder more strongly than the salivary glands, and it binds muscarinic receptors with high specificity. The body also produces an active breakdown product of tolterodine, the 5-hydroxymethyl metabolite, which works in much the same way as the original drug. In people who metabolise tolterodine rapidly (extensive metabolisers), this metabolite plays a significant role in producing the therapeutic effect. Patients can generally expect to see the benefits of treatment within 4 weeks.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended dose is Tolterodine Tartrate 4 mg once daily. Based on individual response and tolerability, the dose may be lowered to 2 mg once daily. For patients with significantly reduced hepatic or renal function, or who are currently taking drugs that are potent inhibitors of CYP3A4, the recommended dose is Tolterodine Tartrate 2 mg daily.
The recommended dose is Tolterodine Tartrate 2 mg twice daily, except in patients with impaired liver function or severely impaired renal function (GFR under 30 ml/min), for whom the recommended dose is one Tolterodine Tartrate 1 mg tablet twice daily. If side effects become troublesome, the dose may be reduced from 2 mg to 1 mg twice daily. The effect of treatment should be re-evaluated after 2 to 3 months.
Pediatric use: The safety and effectiveness of tolterodine in children have not been established.
Geriatric use: No overall differences in safety were observed between older and younger patients treated with Tolterodine.
Side Effects
Dry mouth, headache, constipation, and abdominal pain were the side effects most often reported in patients taking Detrusin LA. Dry mouth was the single most common complaint, occurring in about 23.4% of patients on Detrusin LA tablets compared with 7.7% on placebo. As with other antimuscarinic medicines, Detrusin LA can also be expected to cause dry mouth, constipation, blurred or abnormal vision (from accommodation abnormalities), difficulty passing urine, and dry eyes. These side effects were recorded regardless of whether they were actually caused by the drug.
Cautions & Contraindications
Warnings & Precautions
Detrusin LA should be used with caution in patients who have significant bladder outflow obstruction, since it can raise the risk of urinary retention, and in patients with gastrointestinal obstructive conditions such as pyloric stenosis, since it can raise the risk of gastric retention. Caution is also needed in patients being treated for narrow angle glaucoma. Patients with significantly reduced liver function or kidney function should be given the recommended dose of Detrusin LA at 2 mg daily. In a study looking at the effect of Detrusin LA immediate release tablets on the QT interval, the effect appeared greater at 8 mg per day, twice the therapeutic dose, than at 4 mg per day, and it was more pronounced in CYP2D6 poor metabolizers than in extensive metabolizers. The effect seen with Detrusin LA at 8 mg per day was not as large as that observed after four days of therapeutic dosing with the active control moxifloxacin, though the confidence intervals overlapped. These findings should be kept in mind when deciding whether to prescribe Detrusin LA tablets to patients with a known history of QT prolongation or to patients taking Class IA antiarrhythmic medications such as quinidine or procainamide, or Class III antiarrhythmic medications such as amiodarone or sotalol. Patients should be told that antimuscarinic agents such as Detrusin LA tablets may cause blurred vision, dizziness, or drowsiness.
Contraindications
Tolterodine Tartrate should not be used by patients with urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma, or by anyone who has shown hypersensitivity to Tolterodine Tartrate.
Pregnancy & Breastfeeding
Tolterodine tartrate has not been studied in pregnant women, so it should be used during pregnancy only if the expected benefit to the mother outweighs any possible risk to the unborn baby. It is also not known whether tolterodine passes into breast milk, and for this reason it should not be taken while breastfeeding. Nursing mothers who need this medicine should discuss with their doctor whether to stop breastfeeding or to stop the medicine instead.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Taking too much of Tolterodine Tartrate capsules can cause severe central anticholinergic effects, and it should be treated with that in mind. If an overdose happens, ECG monitoring is recommended.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Tolterodine Tartrate in a cool, dry place and away from light. Make sure children can't reach it.
Drug Interactions
Common questions about Terodin 1 1 mg
What is Terodin 1 1 mg Tablet?
Terodin 1 1 mg Tablet is a medicine that contains Tolterodine Tartrate. It is made by Navana Pharmaceuticals Ltd. It belongs to the Anticholinergics (antimuscarinics)/ Anti-spasmodics group of medicines.
What is Terodin 1 used for?
Detrusin LA is indicated for treating an overactive bladder, with symptoms such as urge urinary incontinence, urgency, and frequency.
What are the side effects of Terodin 1?
Dry mouth, headache, constipation, and abdominal pain were the side effects most often reported in patients taking Detrusin LA. Dry mouth was the single most common complaint, occurring in about 23.4% of patients on Detrusin LA tablets compared with 7.7% on placebo.
Can I take Terodin 1 during pregnancy or while breastfeeding?
Tolterodine tartrate has not been studied in pregnant women, so it should be used during pregnancy only if the expected benefit to the mother outweighs any possible risk to the unborn baby. It is also not known whether tolterodine passes into breast milk, and for this reason it should not be taken while breastfeeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Terodin 1?
Taking too much of Tolterodine Tartrate capsules can cause severe central anticholinergic effects, and it should be treated with that in mind. If an overdose happens, ECG monitoring is recommended. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Terodin 1?
Keep Tolterodine Tartrate in a cool, dry place and away from light. Make sure children can't reach it.
Can I take other medicines with Terodin 1?
Some medicines can interact with Tolterodine Tartrate, for example: Cyclosporine, Erythromycin, Clarithromycin, Itraconazole, Ketoconazole, Miconazole. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Terodin 1?
Terodin 1 is a prescription (Rx) medicine. Take it as your doctor advises.