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All price changes →Terbulin
Rx1.5 mg/5 ml • Syrup
More from Terbulin
Other strengths and forms by Ibn Sina Pharmaceutical Ind. Ltd.
Indications & Uses
Terbutaline Sulfate is used to prevent and to reverse bronchospasm in patients 12 years of age and older. It is given for asthma, and also for reversible bronchospasm linked with bronchitis and emphysema.
Pharmacology
Terbutaline is a relatively selective β2-adrenergic bronchodilator, with little or no effect on alpha-adrenergic receptors. It has a preferential effect on β2-adrenergic receptors, but it stimulates beta-adrenergic receptors less selectively than the relatively selective β2-agonists do. Terbutaline appears to act more strongly on the beta-receptors of bronchial, vascular and uterine smooth muscle (β2 receptors) than on the beta-receptors of the heart (β1 receptors). The medicine relaxes smooth muscle and inhibits uterine contractions, but it may also cause some cardiostimulatory effects and CNS stimulation. Its pharmacologic effects are at least in part due to stimulation, through beta-adrenergic receptors, of intracellular adenyl cyclase. This is the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (c-AMP). Higher c-AMP levels are associated with relaxation of bronchial smooth muscle and with inhibition of the release of mediators of immediate hypersensitivity from cells, especially mast cells.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Terbutaline sulfate tablets and syrup, used in bronchospasm, act for 7 to 8 hours, so the minimum recommended dosage interval is 7 hours. For adults and the elderly, the tablet dose during the first 1 to 2 weeks is 2.5 mg (1 tablet) 3 times in a 24 hour period. The dose may then be increased to 5 mg (2 tablets) 3 times in 24 hours to achieve adequate bronchodilation. With the syrup, the starting dose should be 2×5 ml spoonfuls (3 mg) 3 times in 24 hours, and if necessary it may be increased to 3×5 ml spoonfuls (4.5 mg) 3 times in 24 hours. For children aged 7 to 15 years, the starting tablet dose should normally be 2.5 mg (1 tablet) 2 times in 24 hours. Some patients may need 2.5 mg (1 tablet) 3 times in 24 hours. The syrup dose for children is 0.25 ml (0.075 mg)/kg body weight 3 times in a 24 hour period. The recommended nebuliser solution dose for adults is 1 to 2 Respules, 2 to 4 times a day. Children over 8 years take 1 Respule, 2 to 4 times a day. Younger children are usually prescribed lower doses.
Side Effects
Side effects with Terbutaline Sulfate are not common at the recommended doses. The ones recorded are tremor, headache, tonic cramp and palpitations, and these are all typical of sympathomimetic amines. A few patients feel tense. This comes from the effect on skeletal muscle and not from direct CNS stimulation. When these effects do appear, most of them have usually cleared up on their own within the first week of treatment. Urticaria and exanthema may occur. In children, sleep disturbances and disturbances of behavioural effects have been observed. Treatment with β2-agonists like terbutaline can also cause hypokalaemia, which may be serious.
Cautions & Contraindications
Warnings & Precautions
Take care with patients who have myocardial insufficiency or thyrotoxicosis. Because β2-stimulants raise blood glucose, extra blood glucose checks are recommended at the start of Terbutaline Sulfate therapy in diabetic patients. If a dosage regimen that worked before no longer gives the same relief of symptoms, the patient should see a doctor as soon as possible so that the asthma treatment can be reassessed. β2-agonist therapy can cause potentially serious hypokalaemia. Be particularly careful in severe asthma, because this effect may be increased by xanthine derivatives, steroids and diuretics given at the same time, and by hypoxia. Serum potassium levels should be monitored in these situations. β2-agonists have a positive inotropic effect, so they should not be used in patients with hypertophic cardiomyopathy.
Pregnancy & Breastfeeding
Animal studies and patient experience have shown no teratogenic effects, but Terbutaline should still be given with caution during the first trimester of pregnancy. Terbutaline passes into breast milk. At therapeutic doses, though, an effect on the infant is unlikely.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
An overdose of terbutaline sulfate can cause headache, anxiety, tremor, tonic cramp, palpitations and arrhythmia. Blood pressure sometimes falls as well.
Treatment depends on how severe the case is. In mild and moderate cases, reduce the dose. In severe cases, gastric lavage and activated charcoal are given.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Terbutaline Sulfate in a cool, dry place and away from light.
Drug Interactions
Common questions about Terbulin 1.5 mg/5 ml
What is Terbulin 1.5 mg/5 ml Syrup?
Terbulin 1.5 mg/5 ml Syrup is a medicine that contains Terbutaline Sulfate. It is made by Ibn Sina Pharmaceutical Ind. Ltd. It belongs to the Short-acting selective & β2-adrenoceptor stimulants group of medicines.
What is Terbulin used for?
Terbutaline Sulfate is used to prevent and to reverse bronchospasm in patients 12 years of age and older. It is given for asthma, and also for reversible bronchospasm linked with bronchitis and emphysema.
What are the side effects of Terbulin?
Side effects with Terbutaline Sulfate are not common at the recommended doses. The ones recorded are tremor, headache, tonic cramp and palpitations, and these are all typical of sympathomimetic amines.
Can I take Terbulin during pregnancy or while breastfeeding?
Animal studies and patient experience have shown no teratogenic effects, but Terbutaline should still be given with caution during the first trimester of pregnancy. Terbutaline passes into breast milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Terbulin?
An overdose of terbutaline sulfate can cause headache, anxiety, tremor, tonic cramp, palpitations and arrhythmia. Blood pressure sometimes falls as well. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Terbulin?
Keep Terbutaline Sulfate in a cool, dry place and away from light.
Can I take other medicines with Terbulin?
Some medicines can interact with Terbutaline Sulfate, for example: Propranolol Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Terbulin?
Terbulin is a prescription (Rx) medicine. Take it as your doctor advises.