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These brands contain the same active ingredient (Terbinafine Hydrochloride). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Terbin
Other strengths and forms by Opsonin Pharma Limited
Indications & Uses
Terbin is indicated for:
Pharmacology
Terbinafine is an allylamine antifungal that blocks the biosynthesis of ergosterol, an essential building block of the fungal cell membrane, by inhibiting the enzyme squalene epoxidase. Fungal cells die mainly because squalene builds up to high concentrations and makes the cell membrane abnormally permeable, rather than because of the resulting ergosterol deficiency. Depending on the drug concentration and the fungal species tested in vitro, terbinafine hydrochloride may act as a fungicide, though the clinical relevance of such in vitro findings is not established. Terbinafine has demonstrated activity against most strains of Trichophyton mentagrophytes and Trichophyton rubrum, both in laboratory studies and in actual clinical infections.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For treating fingernail onychomycosis, the usual dose is Terbinafine 250 mg (one tablet) once daily for 6 weeks. For treating toenail onychomycosis, the usual dose is Terbinafine 250 mg (one tablet) once daily for 12 weeks. The best clinical effect is seen some months after mycological cure and stopping treatment, since this is related to the time needed for a healthy nail to grow out.
Dosage for other forms (2)
For body weight under 25 kg, the dose is 125 mg per day for up to 6 weeks. For body weight between 25 and 35 kg, the dose is 187.5 mg per day for up to 6 weeks. For body weight over 35 kg, the dose is 250 mg per day for up to 6 weeks.
The cream can be applied once or twice daily. Cleanse and dry the affected areas thoroughly before applying it. Apply the cream to the affected skin and the surrounding area in a thin layer and rub it in lightly. For intertriginous infections (submammary, interdigital, intergluteal, inguinal), the application may be covered with a gauze strip, especially at night. Likely treatment durations are as follows. Tinea corporis and cruris usually need 1 to 2 weeks. Tinea pedis usually needs 1 week. Cutaneous candidiasis usually needs 2 weeks. Pityriasis versicolor usually needs 2 weeks. Relief of clinical symptoms usually occurs within a few days. Irregular use or stopping treatment too early carries a risk of recurrence. If there are no signs of improvement after two weeks, the diagnosis should be verified.
Terbinafine 1% Spray: This spray is applied once or twice daily, depending on the indication. The affected areas should be cleansed and dried thoroughly before applying the spray, using enough solution to wet the treatment area or areas thoroughly. For tinea pedis, apply once a day for 1 week. For tinea corporis or cruris, apply once a day for 1 week. For pityriasis versicolor, apply twice a day for 1 week. Relief of clinical symptoms usually occurs within a few days. If there are no signs of improvement after two weeks, the diagnosis should be verified.
Side Effects
Reported side effects include gastrointestinal symptoms such as diarrhea, indigestion, and abdominal pain, along with liver test abnormalities, skin rashes, hives, itching, and changes in taste. These effects are usually mild and temporary and generally do not require the medicine to be stopped. Based on worldwide experience with terbinafine, other reported effects include idiosyncratic and symptomatic liver injury and, more rarely, liver failure, which in some cases has led to death or the need for a liver transplant; serious skin reactions; a marked drop in certain white blood cells or platelets; swelling beneath the skin (angioedema); and allergic reactions, including anaphylaxis. Additional reported effects include malaise, fatigue, vomiting, joint pain, muscle pain, and hair loss.
Cautions & Contraindications
Warnings & Precautions
Warnings for Terbitac tablets: Rare cases of liver failure, some leading to death or liver transplant, have occurred with the use of terbinafine tablets for the treatment of onychomycosis in individuals with and without preexisting liver disease. In most of the reported liver cases associated with terbinafine use, the patients had serious underlying systemic conditions, and the causal link with terbinafine was uncertain. The severity of hepatic events and their outcome may be worse in patients with active or chronic liver disease. Treatment with terbinafine tablets should be discontinued if there is biochemical or clinical evidence of liver injury. There have been isolated reports of serious skin reactions (such as Stevens-Johnson Syndrome and toxic epidermal necrolysis). If progressive skin rash occurs, treatment with terbinafine should be discontinued. Terbitac cream is for external use only, and contact with the eyes should be avoided. Precautions: Terbitac is not recommended for patients with chronic or active liver disease. Before prescribing Terbitac, pre-existing liver disease should be assessed, since hepatotoxicity may occur in patients with or without such a history. Pretreatment serum transaminase (ALT and AST) tests are advised for all patients before starting terbinafine tablets.
Contraindications
Terbinafine hydrochloride tablets and cream should not be used by anyone who is hypersensitive to terbinafine.
Pregnancy & Breastfeeding
Terbinafine tablets have not been thoroughly studied in pregnant women, and although animal reproduction studies do not always predict human outcomes, doctors generally advise waiting until after pregnancy to start this medicine, since treatment for nail fungal infection can safely be delayed. Nursing mothers should also avoid the tablets, since the drug passes into breast milk after it is taken by mouth. With the cream, animal studies of fetal toxicity and fertility have not shown adverse effects, but since no clinical experience exists in pregnant women, it should only be used if the potential benefit clearly outweighs the risk. This form is also excreted in breast milk, so breastfeeding mothers should not apply it during treatment.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Children: the safety and efficacy of terbinafine have not been established in pediatric patients.
Elderly: there is no evidence that older patients need different doses from younger ones, or that they get different side-effects.
Overdose
There isn't much clinical experience with overdose of terbinafine tablets. People have taken doses of up to 5 gm, which is 20 times the usual daily therapeutic dose, without serious adverse reactions. The symptoms seen after an overdose were nausea, vomiting, abdominal pain, dizziness, rash, frequent urination and headache.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Terbinafine Hydrochloride in a cool, dry place below 30°C, away from light.
Drug Interactions
Common questions about Terbin 250 mg
What is Terbin 250 mg Tablet?
Terbin 250 mg Tablet is a medicine that contains Terbinafine Hydrochloride. It is made by Opsonin Pharma Limited. It belongs to the Other Antifungal preparations group of medicines.
What is Terbin used for?
Terbin is used for: Fungal Infection.
What are the side effects of Terbin?
Reported side effects include gastrointestinal symptoms such as diarrhea, indigestion, and abdominal pain, along with liver test abnormalities, skin rashes, hives, itching, and changes in taste. These effects are usually mild and temporary and generally do not require the medicine to be stopped.
Can I take Terbin during pregnancy or while breastfeeding?
Terbinafine tablets have not been thoroughly studied in pregnant women, and although animal reproduction studies do not always predict human outcomes, doctors generally advise waiting until after pregnancy to start this medicine, since treatment for nail fungal infection can safely be delayed. Nursing mothers should also avoid the tablets, since the drug passes into breast milk after it is taken by mouth. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Terbin?
There isn't much clinical experience with overdose of terbinafine tablets. People have taken doses of up to 5 gm, which is 20 times the usual daily therapeutic dose, without serious adverse reactions. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Terbin?
Keep Terbinafine Hydrochloride in a cool, dry place below 30°C, away from light.
Can I take other medicines with Terbin?
Some medicines can interact with Terbinafine Hydrochloride, for example: Terbinafine, Propafenone Hydrochloride, Flecainide Acetate. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Terbinox by Ibn Sina Pharmaceutical Ind. Ltd. has the same ingredient and strength for ৳30.00 per unit, compared with ৳60.00 for Terbin. Ask your doctor or pharmacist before switching.
Do I need a prescription for Terbin?
Terbin is a prescription (Rx) medicine. Take it as your doctor advises.