Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →Indications & Uses
Tegazel is indicated for:
Pharmacology
Tegaserod acts on serotonin type-4 (5-HT4) receptors in the gut, where it stimulates the peristaltic reflex and intestinal secretion, dampens visceral sensitivity, and boosts basal motor activity, helping restore normal motility throughout the gastrointestinal tract. Laboratory binding and functional studies show that, at plasma concentrations seen in clinical use, tegaserod also blocks 5-HT2B receptors in humans, and it is expected to bind only weakly to 5-HT1 receptors. It shows no affinity for 5-HT3 or dopamine receptors, and its main metabolite, M29, has negligible affinity for 5-HT4 receptors in vitro. Animal studies confirmed that tegaserod enhances basal motor activity, normalizes disrupted gut motility, and reduces visceral sensitivity during colorectal distension.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage: In adult women under 65, the recommended dose is 6 mg orally, twice daily, taken at least 30 minutes before meals. If symptoms are not adequately controlled after 4 to 6 weeks of treatment, Tegaserod should be discontinued.
Pediatric use: The safety and effectiveness of Tegaserod in pediatric patients have not been established.
Geriatric use: Tegaserod is not indicated for use in patients aged 65 years or older.
Renal impairment: Tegaserod should not be used in patients with severe renal impairment (eGFR below 15 mL/min/1.73 m2) or end-stage renal disease.
Hepatic impairment: Tegaserod should not be used in patients with moderate or severe hepatic impairment.
Side Effects
The most common side effects (occurring in more than 2% of patients) include headache, abdominal pain, nausea, diarrhea, flatulence, dyspepsia, and dizziness.
Cautions & Contraindications
Warnings & Precautions
Cardiovascular Ischemic Events, Including Major Adverse Cardiovascular Events (MACE): Before starting treatment, patients and prescribers should weigh the possible cardiovascular risks against the expected improvement in IBS-C symptoms. Tegazel should be stopped at once if a patient has a heart attack, stroke, transient ischemic attack, or angina. If a patient shows signs of ischemic heart disease, or their overall health changes in a way that could raise cardiovascular risk while on treatment, the benefits and risks of continuing should be reassessed. Ischemic Colitis: Patients should be watched for rectal bleeding, bloody diarrhea, and abdominal pain that is new or getting worse. Tegazel should be discontinued if any of these symptoms appear. Volume Depletion Associated with Diarrhea: Tegazel should not be used in patients who have severe diarrhea. Patients should be told to stop taking Tegazel and contact their healthcare provider right away if they develop severe diarrhea, low blood pressure, or fainting. Suicidal Ideation and Behavior: Patients should be monitored for worsening depression and the emergence of suicidal thoughts or behavior, particularly in the first few months of treatment. They should be advised to stop Tegazel immediately and contact their healthcare provider if their depression persistently worsens or if new suicidal thoughts or behavior appear.
Contraindications
Tegaserod should not be used in people with any of the following conditions. A past heart attack (myocardial infarction), stroke, transient ischaemic attack (TIA), or angina. A past history of ischaemic colitis or any other form of intestinal ischaemia. Severe kidney impairment (eGFR below 15 mL/min/1.73 m2) or end-stage renal disease. Moderate or severe liver impairment. A history of bowel obstruction, symptomatic gallbladder disease, suspected sphincter of Oddi dysfunction, or abdominal adhesions. Known allergy or hypersensitivity to tegaserod.
Pregnancy & Breastfeeding
Available data from case reports of tegaserod use during pregnancy have not shown a link to major birth defects, miscarriage, or other adverse outcomes for the mother or baby. It is not known whether tegaserod passes into human breast milk, or what effect it might have on a nursing infant or on milk supply. In rats, tegaserod and its breakdown products do pass into milk, reaching levels much higher than those found in the mother's blood.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Tegaserod in a cool, dry place. Protect it from light and moisture.
Drug Interactions
Common questions about Tegazel 6 mg
What is Tegazel 6 mg Tablet?
Tegazel 6 mg Tablet is a medicine that contains Tegaserod. It is made by Healthcare Pharmaceuticals Ltd. It belongs to the Drugs for Irritable Bowel Syndrome group of medicines.
What is Tegazel used for?
Tegazel is used for: Constipation, Irritable Bowel Syndrome.
What are the side effects of Tegazel?
The most common side effects (occurring in more than 2% of patients) include headache, abdominal pain, nausea, diarrhea, flatulence, dyspepsia, and dizziness.
Can I take Tegazel during pregnancy or while breastfeeding?
Available data from case reports of tegaserod use during pregnancy have not shown a link to major birth defects, miscarriage, or other adverse outcomes for the mother or baby. It is not known whether tegaserod passes into human breast milk, or what effect it might have on a nursing infant or on milk supply. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Tegazel?
Keep Tegaserod in a cool, dry place. Protect it from light and moisture.
Is there a cheaper medicine with the same ingredient?
Tegazel is already among the lowest-priced brands of Tegaserod at this strength.
Do I need a prescription for Tegazel?
Tegazel is a prescription (Rx) medicine. Take it as your doctor advises.