More from TD-Quine
Other strengths and forms by Techno Drugs Ltd., Gazipur
Indications & Uses
TD-Quine is indicated for:
Pharmacology
Chloroquine phosphate belongs to the 4-aminoquinoline class of antimalarial and amoebicidal medicines. It is used to suppress and clinically cure malaria caused by susceptible strains of *Plasmodium falciparum*, *P. ovale*, *P. vivax*, and *P. malariae*. It works quickly against the blood stages of the parasite (blood schizonts) and also has some activity against gametocytes.
The exact way it acts against blood schizonts is not fully understood, but it is thought to raise the pH within intracellular vesicles of the malaria parasite, which disrupts the parasite's ability to digest haemoglobin. It is also thought to interfere with the parasite's synthesis of nucleoproteins.
When taken by mouth, chloroquine is absorbed rapidly and almost completely from the gastrointestinal tract. Absorption is likewise rapid after intramuscular or subcutaneous injection. Around 55% of the chloroquine circulating in the blood is bound to plasma proteins.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Doses are usually expressed in terms of chloroquine base. As a general guide, chloroquine base 300 mg is roughly equivalent to chloroquine phosphate 500 mg.
For treating an acute attack of malaria: Adults and children are given a total of 25 mg of chloroquine base per kg body weight spread over 3 days. This can be done in different ways. One approach is 10 mg per kg first, followed 6 to 8 hours later by 5 mg per kg, then 5 mg per kg daily for the next 2 days. Another approach is 10 mg per kg daily for the first 2 days, then 5 mg per kg on the 3rd day. Adult doses are sometimes given as fixed amounts rather than by body weight: 600 mg first, followed 6 to 8 hours later by 300 mg, then 300 mg daily for the next 2 days.
For malaria prophylaxis: Adults take an oral dose equal to 300 mg of chloroquine base every 7 days, starting about one week before exposure, continuing throughout exposure, and for at least 4 weeks afterward. Children are usually given a weekly oral dose of 5 mg per kg body weight.
For hepatic amoebiasis: Adults take 600 mg of base daily for 2 days, then 300 mg of base daily for at least 2 to 3 weeks. This is usually combined with an effective intestinal amoebicide.
For discoid and systemic lupus erythematosus: The suggested oral dose is 150 mg of base daily, reduced gradually once symptoms are under control.
For rheumatoid arthritis: Adults take 150 mg of base daily, and some clinicians recommend limiting treatment to 10 months of each year. Children are given 3 mg per kg body weight of base daily.
For managing photoallergic reactions: Adults take 150 to 300 mg of base daily during periods of intense light exposure. Children are given 3 mg per kg body weight.
For porphyria cutanea tarda: When chloroquine was first used for this condition, at doses of 150 mg to 600 mg of base per day for 4 to 7 days, it caused severe, life threatening toxic hepatitis. Using a low dose of 75 mg of base 2 to 3 times per week for 6 to 18 months can avoid this effect and lead to remission.
Side Effects
Gastro-intestinal effects include nausea, vomiting and diarrhoea. Psychological effects can include psychotic episodes, anxiety and personality changes. Visual disturbances may cause blurred vision and difficulty in focusing, along with keratopathy and retinopathy. Haematological effects include aplastic anaemia, agranulocytosis, thrombocytopenia and neutropenia. Other effects include loss of hair, bleaching of hair pigment, bluish black pigmentation of the mucous membranes and skin, photosensitivity, tinnitus, reduced hearing, nerve deafness, uromyopathy and myopathy.
Cautions & Contraindications
Warnings & Precautions
Eyes should be checked before starting long-term treatment and examined periodically during it, as chloroquine can affect vision. Because it may also cause visual disturbances, patients should be cautious about driving or operating machinery. It should be used carefully in patients with reduced liver or kidney function, and in those with porphyria, psoriasis, or a history of epilepsy. Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency should be watched for signs of haemolytic anaemia while on treatment.
Contraindications
Known or suspected chloroquine-resistant P. falciparum. Hypersensitivity to chloroquine. Retinal damage. Concurrent use with hepatotoxic drugs.
Pregnancy & Breastfeeding
Pregnancy: Chloroquine is best avoided in pregnancy. However, if a pregnant woman develops malaria, her physician may still prescribe it for prevention or treatment when the benefit to her is judged to outweigh any possible risk.
Breastfeeding: Chloroquine passes into breast milk and could cause serious harm to a nursing infant. The mother and her physician should therefore decide whether to stop breastfeeding or to stop the medicine, weighing how important the drug is for the mother's own health.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Chloroquine Phosphate below 30°C, away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about TD-Quine 80 mg
What is TD-Quine 80 mg Syrup?
TD-Quine 80 mg Syrup is a medicine that contains Chloroquine Phosphate. It is made by Techno Drugs Ltd., Gazipur. It belongs to the Anti-malarial drugs group of medicines.
What is TD-Quine used for?
TD-Quine is used for: Rheumatoid Arthritis, Malaria.
What are the side effects of TD-Quine?
Gastro-intestinal effects include nausea, vomiting and diarrhoea. Psychological effects can include psychotic episodes, anxiety and personality changes.
Can I take TD-Quine during pregnancy or while breastfeeding?
Pregnancy: Chloroquine is best avoided in pregnancy. However, if a pregnant woman develops malaria, her physician may still prescribe it for prevention or treatment when the benefit to her is judged to outweigh any possible risk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store TD-Quine?
Store Chloroquine Phosphate below 30°C, away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with TD-Quine?
Some medicines can interact with Chloroquine Phosphate, for example: Metronidazole, Mefloquine, Cimetidine, Pyridostigmine, Ampicillin, Ranitidine. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for TD-Quine?
TD-Quine is a prescription (Rx) medicine. Take it as your doctor advises.