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Indications & Uses
Pharmacology
Cefotaxime binds to 1 or more of the penicillin binding proteins (PBPs). This blocks the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall, so the wall can't be built and assembly stops. The result is bacterial cell death.
Cefotaxime is a broad spectrum, bactericidal, 3rd generation parenteral cephalosporin antibiotic. It is exceptionally active against gram-negative organisms, whether they are sensitive or resistant to first or second generation cephalosporins. Against gram-positive bacteria, its activity is similar to that of other cephalosporins.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: The recommended dose for mild to moderate infections is 1 gm every 12 hours. This may be adjusted depending on how severe the infection is, how sensitive the causing organism is, and the patient's condition. For severe infections, the dose may be increased up to 12 gm daily, given in 3 or 4 divided doses. Infections caused by sensitive Pseudomonas species will usually need daily doses greater than 6 gm.
Children: The usual dose ranges from 100 to 150 mg/kg/day, given in 2 to 4 divided doses. For very severe infections, doses of up to 200 mg/kg/day may be needed.
Neonates: The recommended dose is 50 mg/kg/day in 2 to 4 divided doses. For severe infections, doses of 150 to 200 mg/kg/day, in divided doses, have been used.
Dosage in gonorrhoea: 500 mg as a single dose.
Side Effects
Adverse reactions to Cefotax are relatively uncommon and tend to be mild and short-lived. Reported effects include candidiasis, skin rashes, fever, diarrhoea, and transient increases in liver transaminase and/or alkaline phosphatase levels. As with all cephalosporins, pseudomembranous colitis may rarely develop during treatment; if it does, the drug should be discontinued and appropriate treatment started. Also as with other cephalosporins, changes in kidney function have been rarely seen at high doses of Cefotax. Giving high doses of cephalosporins, especially to patients with impaired kidney function, may lead to encephalopathy. Hypersensitivity reactions have also been reported, including skin rashes and drug fever, with anaphylaxis occurring very rarely.
Cautions & Contraindications
Warnings & Precautions
Cefotax should be used cautiously in anyone with a history of gastrointestinal disease, especially colitis. In patients whose urinary output is reduced, whether temporarily or persistently, due to poor kidney function, the usual doses can lead to unusually high and prolonged antibiotic levels in the body. For this reason, the total daily dose should be lowered when giving Cefotax to these patients, with further dosing guided by the degree of kidney impairment, the severity of the infection, and how susceptible the causative organism is. That said, there is no clinical evidence indicating that Cefotax dosing needs to be changed even in patients with severe kidney dysfunction.
Contraindications
Cefotaxime should not be used in anyone known to be hypersensitive to cefotaxime itself or to other cephalosporin antibiotics.
Pregnancy & Breastfeeding
Although animal studies have not shown any harmful effect on the developing foetus, the safety of Cefotaxime during human pregnancy has not been established. Because of this, Cefotaxime should not be given during pregnancy, particularly in the first trimester, unless the expected benefit is carefully weighed against the possible risks. Cefotaxime does pass into breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Dosage in renal impairment: Cefotaxime (Cefot) is partly cleared from the body by routes other than the kidneys, so the dose only needs to be reduced in severe renal failure (GFR<5 ml/min, which is a serum creatinine of approximately 751 micromol/litre). Give an initial loading dose of 1 gm, then halve the daily dose and keep the same frequency of dosing. In all other patients, the dose may need further adjustment depending on how the infection is going and the general condition of the patient.
Storage
Keep Cefotaxime below 25°C, away from light and moisture. Once the solution has been reconstituted, use it straight away. If it can't be used at once, the reconstituted solution stays stable for up to 24 h when kept between 2° to 8°C.
Drug Interactions
Common questions about Taxceph 250 mg/5 ml
What is Taxceph 250 mg/5 ml IM/IV Injection?
Taxceph 250 mg/5 ml IM/IV Injection is a medicine that contains Cefotaxime. It is made by Ibn Sina Pharmaceutical Ind. Ltd. It belongs to the Third generation cephalosporins group of medicines.
What is Taxceph used for?
Taxceph is used for: Chronic Obstructive Pulmonary Disease, Pneumonia, Bronchitis, Bacterial Infection, Urinary Tract Infection, Respiratory Tract Infection, Sepsis.
What are the side effects of Taxceph?
Adverse reactions to Cefotax are relatively uncommon and tend to be mild and short-lived. Reported effects include candidiasis, skin rashes, fever, diarrhoea, and transient increases in liver transaminase and/or alkaline phosphatase levels.
Can I take Taxceph during pregnancy or while breastfeeding?
Although animal studies have not shown any harmful effect on the developing foetus, the safety of Cefotaxime during human pregnancy has not been established. Because of this, Cefotaxime should not be given during pregnancy, particularly in the first trimester, unless the expected benefit is carefully weighed against the possible risks. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Taxceph?
Keep Cefotaxime below 25°C, away from light and moisture. Once the solution has been reconstituted, use it straight away.
Can I take other medicines with Taxceph?
Some medicines can interact with Cefotaxime, for example: Gentamicin, Amikacin, Tobramycin, Frusemide. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Taxceph?
Taxceph is a prescription (Rx) medicine. Take it as your doctor advises.