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These brands contain the same active ingredient (Mirogabalin Besylate). Same strength and form. Confirm the switch with your doctor or pharmacist.
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Other strengths and forms by Opsonin Pharma Limited
Indications & Uses
Targaba is indicated for:
Pharmacology
Mirogabalin belongs to the class of gamma amino acids and their derivatives. It binds selectively to the α2δ subunits of voltage-gated calcium channels (VGCCs). This reduces calcium (Ca2+) influx and neurotransmission, which in turn inhibits the release of neurotransmitters at the presynaptic nerve endings. With less neurotransmitter released, the hyper-excitability of central nervous system (CNS) neurons decreases.
After oral administration, mirogabalin is absorbed rapidly, and the median time to maximum plasma concentration is 0.5 to 1.5 h. Plasma protein binding is low, at approximately 25%. The mean apparent volume of distribution is 64 to 88 L after single or multiple doses. Most of the drug is cleared unchanged (61 to 72%) through the kidneys, by filtration and active secretion. A slight fraction (13 to 20%) is metabolized by hepatic uridine 5'-diphospho-glucuronosyltransferase isoforms. The mean elimination half-life of mirogabalin was observed to be 2 to 4.9 h. About 99% of the drug is excreted through the kidneys, and only 1% of the dose goes out through the feces.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adult dose: Adults start on 5 mg of Mirogabalin twice daily. The dose is then raised slowly, by 5 mg at a time with at least a week between each step, up to 15 mg twice daily. Depending on the person's age and symptoms, the doctor may adjust it anywhere between 10 mg and 15 mg twice daily.
Use in Children and Adolescent: It is not known if Mirogabalin is safe and effective in children and adolescents.
Hepatic Impairment: A single 15 mg dose of Mirogabalin did not produce significant adverse reactions in patients with mild to moderate hepatic impairment. No data are available for severe hepatic impairment.
Renal Impairment: In mild renal dysfunction, the starting dose is 5 mg twice a day. It is increased slowly by 5 mg at an interval of 1 week, up to 10 mg. In moderate renal dysfunction, the starting dose is 2.5 mg twice a day, increased slowly by 2.5 mg at an interval of 1 week, up to 7.5 mg twice a day. In severe renal dysfunction, the starting dose is 2.5 mg once a day, increased slowly by 2.5 mg at an interval of 1 week, up to 7.5 mg once a day.
Side Effects
The most commonly reported side effects of Mirogabalin Besylate are somnolence (sleepiness), dizziness, edema and weight gain. The symptoms below are rarely seen as early signs of the side effects named in brackets. If any of them occur, stop taking the medicine and see your doctor immediately. Light headedness, a state close to sleep with impaired consciousness, and loss of consciousness (dizziness, somnolence, unconsciousness). General malaise, loss of appetite, nausea, vomiting and jaundice (liver dysfunction).
Cautions & Contraindications
Warnings & Precautions
Mirogabalin Besylate may cause dizziness, somnolence or loss of consciousness, so don't operate dangerous machinery, and that includes driving a car. Take special care with elderly patients. The medicine may also cause weight gain, and it can cause blurred vision and double vision. If an allergic reaction occurs, stop taking the medicine and consult a doctor. Patients with renal dysfunction need a dose adjustment. If you are taking any other medicine, talk to your doctor before you start Mirogabalin Besylate. Because dizziness or somnolence can happen, the patient should stay away from potentially hazardous activities such as driving a car. Elderly patients should be aware of the risk of falling and fracture. If signs of blurred vision or double vision appear while taking this medicine, the patient should consult the doctor.
Contraindications
Mirogabalin must not be given to patients who are hypersensitive to Mirogabalin. It is also contraindicated in patients with mild to moderate hepatic and renal impairment.
Pregnancy & Breastfeeding
Women who are pregnant, or who may be pregnant, should be given Mirogabalin Besylate only when the benefit of treatment is greater than the risk. In animal studies, the medicine has been reported to pass across the placenta.
For breastfeeding, the doctor should weigh the benefit of treatment against the benefit of breastfeeding, and then decide whether to continue or stop breastfeeding. Animal studies have also reported that Mirogabalin Besylate is transferred into milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Mirogabalin Besylate in a dry place below 30°C, away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Targaba 5 mg
What is Targaba 5 mg Tablet?
Targaba 5 mg Tablet is a medicine that contains Mirogabalin Besylate. It is made by Opsonin Pharma Limited. It belongs to the Adjunct anti-epileptic drugs group of medicines.
What is Targaba used for?
Targaba is used for: Neuropathic Pain, Pain.
What are the side effects of Targaba?
The most commonly reported side effects of Mirogabalin Besylate are somnolence (sleepiness), dizziness, edema and weight gain. The symptoms below are rarely seen as early signs of the side effects named in brackets.
Can I take Targaba during pregnancy or while breastfeeding?
Women who are pregnant, or who may be pregnant, should be given Mirogabalin Besylate only when the benefit of treatment is greater than the risk. In animal studies, the medicine has been reported to pass across the placenta. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Targaba?
Keep Mirogabalin Besylate in a dry place below 30°C, away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Targaba?
Some medicines can interact with Mirogabalin Besylate, for example: Lorazepam, Cimetidine, Mirogabalin. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Migaba by Team Pharmaceuticals Ltd. has the same ingredient and strength for ৳18.00 per unit, compared with ৳20.00 for Targaba. Ask your doctor or pharmacist before switching.
Do I need a prescription for Targaba?
Targaba is a prescription (Rx) medicine. Take it as your doctor advises.