Pricing
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All price changes →Indications & Uses
Valbenazine Tosylate is used to treat adults who have Tardive Dyskinesia.
Pharmacology
Valbenazine and its active metabolites bind to vesicular monoamine transporter 2 (VMAT2) and block it. They do this with high selectivity, and they don't bind in any significant way to VMAT1. With VMAT2 blocked, the monoamine neurotransmitters noradrenaline, dopamine and serotonin can't be taken back up and stored in synaptic vesicles, so they are left open to being broken down by cytosolic enzymes. There are then fewer vesicles carrying packaged neurotransmitter ready for release into the synapse, and the presynaptic release of these monoamines falls. Neither valbenazine nor its active metabolite shows significant off-target binding at dopamine, serotonin or adrenaline receptors.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Valbenazine tosylate is started at 40 mg once daily. After one week, the dose goes up to the recommended 80 mg once daily. For some patients, though, staying on 40 mg once daily may be considered. The medicine is taken by mouth, and it can be taken with or without food.
Side Effects
Somnolence and QT prolongation.
Cautions & Contraindications
Warnings & Precautions
Valbenazine Tosylate can make you drowsy, so it may affect your ability to drive or work with hazardous machinery. It may also prolong the QT interval. Avoid it in patients with congenital long QT syndrome, or with arrhythmias linked to a prolonged QT interval. Patients who are CYP2D6-poor metabolizers, or who are taking a strong CYP2D6 inhibitor, may need a lower dose. In mild to moderate renal impairment, no dose adjustment is needed. In severe renal impairment, valbenazine is not recommended.
Pregnancy & Breastfeeding
There isn't enough data on Valbenazine use in pregnant women to say whether it carries a risk to the pregnancy. A woman should not breastfeed while she is taking valbenazine, and she should also avoid it for 5 days after her last dose.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
The clinical trials of valbenazine don't say what symptoms an overdose might cause, and no specific antidote for valbenazine is known. If an overdose happens, the patient should get supportive care with close medical supervision and monitoring. It's also worth considering that more than one drug may be involved.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Valbenazine Tosylate below 25°C, in a cool and dry place, and keep it away from light. Keep all medicines out of the reach of children.
Drug Interactions
Common questions about Tardivex 40 mg
What is Tardivex 40 mg Capsule?
Tardivex 40 mg Capsule is a medicine that contains Valbenazine Tosylate. It is made by Everest Pharmaceuticals Ltd.
What is Tardivex used for?
Valbenazine Tosylate is used to treat adults who have Tardive Dyskinesia.
What are the side effects of Tardivex?
Somnolence and QT prolongation.
Can I take Tardivex during pregnancy or while breastfeeding?
There isn't enough data on Valbenazine use in pregnant women to say whether it carries a risk to the pregnancy. A woman should not breastfeed while she is taking valbenazine, and she should also avoid it for 5 days after her last dose. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Tardivex?
The clinical trials of valbenazine don't say what symptoms an overdose might cause, and no specific antidote for valbenazine is known. If an overdose happens, the patient should get supportive care with close medical supervision and monitoring. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Tardivex?
Store Valbenazine Tosylate below 25°C, in a cool and dry place, and keep it away from light. Keep all medicines out of the reach of children.
Can I take other medicines with Tardivex?
Some medicines can interact with Valbenazine Tosylate, for example: Digoxin, Valbenazine. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Tardivex is already among the lowest-priced brands of Valbenazine Tosylate at this strength.
Do I need a prescription for Tardivex?
Tardivex is a prescription (Rx) medicine. Take it as your doctor advises.