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Same active ingredient — pay up to 25% less
These brands contain the same active ingredient (Tamoxifen Citrate). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Tamoxifen Citrate is used to treat breast cancer and infertility.
Pharmacology
Tamoxifen is a non-steroidal, triphenylene based drug. Its effects are mixed, because it acts as an oestrogen antagonist in some tissues and has oestrogen agonist like effects in others. In breast cancer patients, at the level of the tumour, Tamoxifen works mainly as an antioestrogen and stops oestrogen from binding to the oestrogen receptor. It has also been reported to help maintain bone mineral density in post-menopausal women.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For breast cancer, the adult dose of Tamoxifen Citrate is 20 mg daily.
For anovulatory infertility, the dose is 20 mg daily on days 2, 3, 4 and 5 of the cycle. If needed, the dose may be increased to 40 mg and then 80 mg for later courses. When cycles are irregular, the first course can be started on any day. The next course then follows 45 days later, or on day 2 of the cycle if menstruation occurs.
Side Effects
Side effects of Tamoxifen Citrate fall into two groups. Some come from the way the medicine works in the body, such as hot flushes, vaginal bleeding, vaginal discharge, pruritus vulvae and tumour flare. Others are more general, such as gastrointestinal intolerance, headache, light-headedness, and occasionally fluid retention and alopecia. When these effects are severe, a simple reduction of the dose (within the recommended dose range) may bring them under control without losing control of the disease. Skin rashes have been reported, including isolated reports of erythema multiforme, Stevens Johnson syndrome and bullous pemphigoid. Rare hypersensitivity reactions, including angio-oedema, have also been reported. A small number of patients with bony metastases have developed hypercalcaemia when treatment was started. In patients taking Tamoxifen Citrate for breast cancer, platelet counts have fallen, usually only to 80,000-90,000 per/mm3 but occasionally lower. A number of cases of visual disturbances have been described in patients on this therapy, including infrequent reports of corneal changes and retinopathy. An increased incidence of cataracts has also been reported with the medicine. Uterine fibroids and endometrial changes, including hyperplasia and polyps, have been reported. Cystic ovarian swellings have occasionally been seen in premenopausal women receiving Tamoxifen Citrate. Leucopenia has been observed after Tamoxifen Citrate was given, sometimes together with anaemia and/or thrombocytopenia. Neutropenia has been reported on rare occasions, and it can sometimes be severe. There is evidence of an increased incidence of thromboembolic events, including deep vein thrombosis and pulmonary embolism, during therapy. Tamoxifen Citrate has been linked with changes in liver enzyme levels. On rare occasions it has also been linked with a spectrum of more severe liver abnormalities, including fatty liver, cholestasis and hepatitis. Rarely, serum triglyceride levels may rise, in some cases with pancreatitis, and this may be associated with the use of Tamoxifen Citrate.
Cautions & Contraindications
Warnings & Precautions
Menstruation stops in some premenopausal women who take Tamoxifen Citrate for breast cancer. A higher number of endometrial cancers has also been reported in people on this treatment. The underlying mechanism isn't known, but it may be related to the oestrogen-like effect of the medicine. Any patient who is taking Tamoxifen Citrate, or has taken it in the past, and reports abnormal gynaecological symptoms, especially vaginal bleeding, should be investigated promptly. Clinical trials have also reported a number of second primary tumours in breast cancer patients after treatment, at sites other than the endometrium and the opposite breast. No causal link has been established, and the clinical significance of these observations remains unclear.
Contraindications
Tamoxifen must not be given during pregnancy. It should also not be given to anyone who has had a hypersensitivity reaction to tamoxifen or to any of its ingredients.
Pregnancy & Breastfeeding
Pregnancy: Tamoxifen must not be given during pregnancy. A small number of women who took Tamoxifen have reported miscarriages, birth defects and deaths of the foetus, although no causal relationship has been established. Reproductive toxicology studies in rats, rabbits and monkeys showed no teratogenic potential. Women should be advised not to become pregnant while taking Tamoxifen, and if they are sexually active they should use barrier or other nonhormonal contraceptive methods. Premenopausal patients must be examined carefully before treatment to exclude pregnancy. If a woman wants to become pregnant while taking Tamoxifen, or within two months of stopping therapy, she should be told about the possible risks to the foetus.
Lactation: It is not known if Tamoxifen is excreted in human milk, so the medicine is not recommended during lactation. When deciding whether to stop Tamoxifen, the doctor should take into account how important the medicine is for the breastfeeding mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Tamoxifen Citrate at 20 to 25° C and protect it from light.
Common questions about Tamiren 20 mg
What is Tamiren 20 mg Tablet?
Tamiren 20 mg Tablet is a medicine that contains Tamoxifen Citrate. It is made by Renata PLC. It belongs to the Hormonal Chemotherapy group of medicines.
What is Tamiren used for?
Tamoxifen Citrate is used to treat breast cancer and infertility.
What are the side effects of Tamiren?
Side effects of Tamoxifen Citrate fall into two groups. Some come from the way the medicine works in the body, such as hot flushes, vaginal bleeding, vaginal discharge, pruritus vulvae and tumour flare.
Can I take Tamiren during pregnancy or while breastfeeding?
Pregnancy: Tamoxifen must not be given during pregnancy. A small number of women who took Tamoxifen have reported miscarriages, birth defects and deaths of the foetus, although no causal relationship has been established. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Tamiren?
Keep Tamoxifen Citrate at 20 to 25° C and protect it from light.
Is there a cheaper medicine with the same ingredient?
Tamoxi by Beacon Pharmaceuticals PLC has the same ingredient and strength for ৳12.00 per unit, compared with ৳16.00 for Tamiren. Ask your doctor or pharmacist before switching.
Do I need a prescription for Tamiren?
Tamiren is a prescription (Rx) medicine. Take it as your doctor advises.