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Indications & Uses
Talaparib is indicated for:
Pharmacology
Talazoparib blocks poly (ADP-ribose) polymerase (PARP) enzymes, including PARP1 and PARP2, which help the cell repair its DNA. Laboratory studies used cancer cell lines with defects in DNA repair genes, including BRCA1 and BRCA2. In these studies, the cell-killing effect of Talazoparib may involve two things: inhibition of PARP enzymatic activity, and a greater build-up of PARP-DNA complexes. Together these lead to DNA damage, slower cell proliferation and apoptosis. Talazoparib also showed anti-tumor activity in patient-derived xenograft breast cancer models that carried mutated BRCA1, mutated BRCA2, or wild type BRCA1 and BRCA2.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For gBRCAm HER2-negative locally advanced or metastatic breast cancer, patients should be selected for Talazoparib treatment based on the presence of germline BRCA mutations. In HRR gene-mutated metastatic castration-resistant prostate cancer (mCRPC), selection is based on the presence of HRR gene mutations (ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, or RAD51C). The recommended dosage of Talazoparib in gBRCAm HER2-negative locally advanced or metastatic breast cancer is 1 mg taken orally once daily until disease progression or unacceptable toxicity. If adverse reactions occur, interrupting the dose or reducing it should be considered. The recommended dosage in HRR gene-mutated mCRPC is 0.5 mg taken orally once daily in combination with Enzalutamide, also until disease progression or unacceptable toxicity. Talazoparib can be taken with or without food. The capsules should be swallowed whole, and they should not be opened or dissolved. If a patient vomits or misses a dose, they should be told to take the next prescribed dose at the usual time.
Side Effects
When talazoparib is used on its own, the most common side effects (seen in more than 20% of people) include changes in blood and laboratory results as well as symptoms. On the blood side, haemoglobin, neutrophils, lymphocytes and platelets are decreased, and calcium is decreased too. Glucose, aspartate aminotransferase, alkaline phosphatase and alanine aminotransferase are increased. The symptoms people report are fatigue, nausea, headache, vomiting, hair loss (alopecia), diarrhoea and decreased appetite.
Cautions & Contraindications
Warnings & Precautions
MDS/AML (Myelodysplastic Syndrome/Acute Myeloid Leukemia) has been reported in patients who received Talazoparib, and some of these cases were fatal. If MDS/AML is confirmed, stop the medicine. Myelosuppression, which means anemia, neutropenia and/or thrombocytopenia, has also been reported in patients treated with Talazoparib. If these blood problems do not resolve within 28 days, stop the medicine and refer the patient to a hematologist for further investigations, including bone marrow analysis and a blood sample for cytogenetics. On embryo-fetal toxicity, Talazoparib can cause fetal harm when given to a pregnant woman. This is based on its mechanism of action and on findings from animal data. On infertility, animal studies show it may impair fertility in males of reproductive potential.
Pregnancy & Breastfeeding
Pregnancy: Animal studies and the way Talazoparib works in the body suggest it can harm an unborn baby when given to a pregnant woman. There are no data on the use of Talazoparib in pregnant women, so the actual risk from the medicine is not known. Pregnant women, and women who could become pregnant, should be told about the possible risk to the baby.
Lactation: No data exist on whether Talazoparib passes into human breast milk. Nothing is known either about its effect on milk production or on a breastfed child.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: The safety and effectiveness of Talazoparib have not been established in pediatric patients.
Geriatric use: Clinical trials of Talazoparib enrolled 494 patients with advanced solid tumors, and all of them received 1 mg daily as a single agent. Of these, 85 patients (17%) were older than 65 years, including 19 patients (4%) older than 75 years. There were 5 patients older than 85 years. In the TALAPRO-2 trial, 197 patients received Talazoparib, and 77% of them were older than 65 years while 30% were older than 75 years. The older patients showed no overall differences in safety or effectiveness compared with younger patients.
Hepatic impairment: No dosage modification is recommended for patients with hepatic impairment.
Renal impairment: The recommended dosage should be reduced in patients with moderate renal impairment (CrCl 30 to 59 mL/min) and in those with severe renal impairment (CrCl 15 to 29 mL/min). For mild renal impairment (CrCl 60 to 89 mL/min), no dose adjustment is recommended. Talazoparib has not been studied in patients who need hemodialysis.
Storage
Keep Talazoparib in a cool, dry place where the temperature stays below 30°C. Protect it from light, and keep it out of the reach of children.
Drug Interactions
Common questions about Talaparib 1 mg
What is Talaparib 1 mg Capsule?
Talaparib 1 mg Capsule is a medicine that contains Talazoparib. It is made by Everest Pharmaceuticals Ltd. It belongs to the Cytotoxic Chemotherapy group of medicines.
What is Talaparib used for?
Talaparib is used for: Cancer.
What are the side effects of Talaparib?
When talazoparib is used on its own, the most common side effects (seen in more than 20% of people) include changes in blood and laboratory results as well as symptoms. On the blood side, haemoglobin, neutrophils, lymphocytes and platelets are decreased, and calcium is decreased too.
Can I take Talaparib during pregnancy or while breastfeeding?
Pregnancy: Animal studies and the way Talazoparib works in the body suggest it can harm an unborn baby when given to a pregnant woman. There are no data on the use of Talazoparib in pregnant women, so the actual risk from the medicine is not known. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Talaparib?
Keep Talazoparib in a cool, dry place where the temperature stays below 30°C. Protect it from light, and keep it out of the reach of children.
Can I take other medicines with Talaparib?
Some medicines can interact with Talazoparib, for example: Carvedilol, Clarithromycin, Itraconazole, Verapamil Hydrochloride, Amiodarone Hydrochloride, Enzalutamide. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Talaparib is already among the lowest-priced brands of Talazoparib at this strength.
Do I need a prescription for Talaparib?
Talaparib is a prescription (Rx) medicine. Take it as your doctor advises.