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Same active ingredient — pay up to 10% less
These brands contain the same active ingredient (Bisoprolol Fumarate + Hydrochlorothiazide). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Tabis Plus
Other strengths and forms by Navana Pharmaceuticals Ltd.
Indications & Uses
Tabis Plus is indicated for:
Pharmacology
Bisoprolol Fumarate and Hydrochlorothiazide have both been used for hypertension, either on their own or together. Their blood pressure lowering effects add to each other, and Hydrochlorothiazide 6.25 mg clearly increases the effect of Bisoprolol Fumarate. Hypokalemia also happens much less often with the Bisoprolol Fumarate and Hydrochlorothiazide 6.25 mg combination than with Hydrochlorothiazide 25 mg.
Bisoprolol Fumarate is a β1-selective (cardioselective) adrenoceptor blocking agent. In its therapeutic dose range it has no significant membrane stabilizing activity and no significant intrinsic sympathomimetic activity. Hydrochlorothiazide is a benzothiadiazine diuretic. Thiazides act on the mechanisms in the renal tubules that reabsorb electrolytes, and they increase the excretion of sodium and chloride in approximately equal amounts.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Bisoprolol works well for hypertension at once-daily doses of 2.5 to 40 mg, and hydrochlorothiazide works well at doses of 12.5 to 50 mg. In clinical trials of the bisoprolol and hydrochlorothiazide combination, bisoprolol doses were 2.5 to 20 mg and hydrochlorothiazide doses were 6.25 to 25 mg. The blood pressure lowering effect grew as the dose of either component went up.
For initial therapy, treatment can start with the lowest dose of this combination, one 2.5/6.25 mg tablet once daily. The dose can then be raised at 14 day intervals, as appropriate, up to the maximum recommended dose of 20/12.5 mg once daily.
For replacement therapy, the combination can be used in place of the individual components once their doses have been titrated.
Treatment can also be guided by clinical effect. A patient whose blood pressure is not adequately controlled with 2.5 to 20 mg of bisoprolol daily may be given this combination instead. Some patients have their blood pressure adequately controlled with 50 mg of hydrochlorothiazide daily but lose a significant amount of potassium on it. If these patients are switched to this combination, they may get similar blood pressure control without the electrolyte disturbance.
Side Effects
Bisoprolol Fumarate + Hydrochlorothiazide is generally well tolerated, and most of the side effects seen so far have been mild and short-lived. The ones that may occur are fatigue, dizziness, headache, bradycardia, arrhythmia, peripheral ischemia, chest pain, palpitations, rhythm disturbances, cold extremities, claudication and orthostatic hypotension. Some people may also have diarrhoea, constipation, nausea, dyspepsia, rhinitis, pharyngitis and similar complaints.
Cautions & Contraindications
Warnings & Precautions
Some patients taking thiazide diuretics may develop hyperuricemia or an attack of acute gout. Bisoprolol Fumarate + Hydrochlorothiazide can also upset the body's fluid and electrolyte balance, and hypokalemia may develop. The warning signs are dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria and tachycardia. Stomach and bowel upset such as nausea and vomiting can also occur. If the doctor plans to stop Bisoprolol Fumarate + Hydrochlorothiazide, this should be done gradually over about 2 weeks. Patients should be carefully observed during this time.
Contraindications
Bisoprolol Fumarate + Hydrochlorothiazide must not be given to patients in cardiogenic shock, overt cardiac failure, second or third degree AV block, marked sinus bradycardia or anuria. It is also contraindicated in anyone who is hypersensitive to either component of this product or to other sulfonamide-derived drugs.
Pregnancy & Breastfeeding
Bisoprolol Fumarate and Hydrochlorothiazide falls under Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women, so the combination should be used in pregnancy only if the potential benefit justifies the risk to the fetus.
Bisoprolol Fumarate, alone or together with Hydrochlorothiazide, has not been studied in nursing mothers. Thiazides are excreted in human breast milk. Small amounts of Bisoprolol Fumarate have been detected in the milk of lactating rats. Because nursing infants could have serious adverse reactions, a decision should be made whether to stop nursing or to stop the medicine, taking into account how important the medicine is to the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
There isn't much data on overdose with Bisoprolol Fumarate + Hydrochlorothiazide. The signs you would most often expect from a beta-blocker overdose are bradycardia and hypotension. Lethargy is also common. In severe overdoses, delirium, coma, convulsions and respiratory arrest have been reported. Congestive heart failure, bronchospasm and hypoglycemia may also occur.
Acute intoxication with thiazide diuretics is rare. The most prominent feature of an overdose is a sudden loss of fluid and electrolytes. The signs and symptoms fall into these groups:
cardiovascular (tachycardia, hypotension, shock), neuromuscular (weakness, confusion, dizziness, cramps of the calf muscles, paresthesia, fatigue, impairment of consciousness), gastrointestinal (nausea, vomiting, thirst), renal (polyuria, oliguria or anuria), and laboratory findings (hypokalemia, hyponatremia, hypochloremia, alkalosis, increased BUN [especially in patients with renal insufficiency]).
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Bisoprolol Fumarate + Hydrochlorothiazide below 30°C, away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Tabis Plus 5 mg+6.25 mg
What is Tabis Plus 5 mg+6.25 mg Tablet?
Tabis Plus 5 mg+6.25 mg Tablet is a medicine that contains Bisoprolol Fumarate + Hydrochlorothiazide. It is made by Navana Pharmaceuticals Ltd. It belongs to the Combined antihypertensive preparations group of medicines.
What is Tabis Plus used for?
Tabis Plus is used for: Hypertension.
What are the side effects of Tabis Plus?
Bisoprolol Fumarate + Hydrochlorothiazide is generally well tolerated, and most of the side effects seen so far have been mild and short-lived. The ones that may occur are fatigue, dizziness, headache, bradycardia, arrhythmia, peripheral ischemia, chest pain, palpitations, rhythm disturbances, cold extremities, claudication and orthostatic hypotension.
Can I take Tabis Plus during pregnancy or while breastfeeding?
Bisoprolol Fumarate and Hydrochlorothiazide falls under Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women, so the combination should be used in pregnancy only if the potential benefit justifies the risk to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Tabis Plus?
There isn't much data on overdose with Bisoprolol Fumarate + Hydrochlorothiazide. The signs you would most often expect from a beta-blocker overdose are bradycardia and hypotension. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Tabis Plus?
Store Bisoprolol Fumarate + Hydrochlorothiazide below 30°C, away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Tabis Plus?
Some medicines can interact with Bisoprolol Fumarate + Hydrochlorothiazide, for example: Disopyramide, Bisoprolol Fumarate, Clonidine Hydrochloride, Verapamil Hydrochloride, Diltiazem Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Bisten Plus by Edruc Ltd. has the same ingredient and strength for ৳9.00 per unit, compared with ৳10.00 for Tabis Plus. Ask your doctor or pharmacist before switching.
Do I need a prescription for Tabis Plus?
Tabis Plus is a prescription (Rx) medicine. Take it as your doctor advises.