Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →Save on this medicine
Same active ingredient — pay up to 14% less
These brands contain the same active ingredient (Undenatured Type II Collagen + Glucosamine sulfate + Boswellia serrata + Boron). Same strength and form. Confirm the switch with your doctor or pharmacist.
Synogen B
Rx20 mg+750 mg+50 mg+0.75 mg • Tablet
Indications & Uses
Undenatured Type II Collagen + Glucosamine sulfate + Boswellia serrata + Boron tablet is used to give superior support to aging joints. It's a next-generation, multi-nutrient formula based on the latest research. Boswellia inhibits the 5-LOX enzyme, and the undenatured Type II collagen is a standardized chicken cartilage extract that supports joint comfort and ease of motion.
Pharmacology
Undenatured Type II collagen is a nutritional supplement made from chicken sternum cartilage. A patented, low-temperature, non-enzymatic process is used to make it, and this keeps the natural triple helix shape of the molecule and its biological activity. It works in an unusual way. The molecules carry active binding sites called epitopes, and these start a process called oral tolerization. In this process, the epitopes interact with the Peyer's patches (lymphoid tissue) of the small intestine, and T-cells are turned into T regulatory cells. The T regulatory cells then travel to the joint area and release anti-inflammatory mediators (cytokines), including transforming growth factor-beta (TGF-beta) and interleukin 10 (IL-10). So joint inflammation is reduced and cartilage repair is promoted. According to ORSI (Osteoarthritis Research Society International), taking Undenatured Type II collagen by mouth reduced the deterioration of articular cartilage in osteoarthritis (OA). Glucosamine sulfate is a natural supplement. It is a sugar protein that helps build cartilage. Glucosamine is a normal part of the glycosaminoglycans in cartilage matrix and synovial fluid, and it could have various pharmacological actions in articular cartilage and joint tissues. In a randomized, placebo-controlled clinical trial, long-term use of Glucosamine sulphate could prevent joint structure changes in patients with osteoarthritis of the knee, with a significant improvement in symptoms. Boswellia serrata is a plant extract that supports joint health by inhibiting inflammatory factors such as the 5-lipoxygenase (5-LOX) enzyme and leukotriene B4, which affect aging joints. Extracts of Boswellia serrata have been studied clinically for osteoarthritis, joint function and joint pain. Boswellia may also help reduce cartilage damage in arthritis. In a placebo-controlled clinical study, Boswellia extract improved signs of joint discomfort in just 8 weeks. Boswellia serrata is seen as a promising alternative to NSAIDs. Boron (calcium fructoborate) is a patented complex of calcium, fructose and boron, found naturally in fresh and dried fruits, vegetables and herbs. Calcium fructoborate significantly reduces the C-reactive protein in humans. This unique plant-mineral complex contributes to bone health by controlling the inflammation linked with loss of bone mineral density.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults take 1 tablet by mouth twice a day after a meal, or as the doctor directs. The combination of Undenatured Type II Collagen, Glucosamine sulfate, Boswellia serrata and Boron hasn't been shown to be safe and effective in children below 12 years of age.
Side Effects
Glucosamine sulfate seems to be safe for most people. When side effects do occur, they are usually mild and include nausea, heartburn, diarrhea and constipation. Drowsiness, skin reactions and headache are less common. Some glucosamine products don't contain the amount of glucosamine printed on the label, and some contain too much Manganese.
Cautions & Contraindications
Warnings & Precautions
People with diabetes who take this combination, which contains glucosamine, should check their blood glucose levels regularly. No special studies have been confirmed in patients with kidney or liver insufficiency. Even so, if a patient has severe renal or hepatic insufficiency, the medicine should be given under proper medical supervision.
Contraindications
Some groups of patients should take these supplements only under close medical supervision, or avoid them altogether. Diabetic patients should use Glucosamine sulfate supplements only under close medical supervision, because some studies suggest that Glucosamine sulfate may increase insulin resistance. Patients who are allergic to shellfish should talk to their doctor before taking Glucosamine sulfate supplements. That said, a shellfish allergy doesn't usually stop someone from taking glucosamine sulfate. It is extracted from chitin, which is a carbohydrate, while shellfish allergies are most often caused by a protein. Children, and women who are pregnant, nursing or could become pregnant, are also in this group. There is currently not enough research to say whether glucosamine and chondroitin sulfate supplements have negative effects on young children or on a fetus. Patients who have any adverse reactions or unusual side effects to glucosamine supplements should stop taking them immediately and consult their doctor.
Pregnancy & Breastfeeding
This combination is not recommended during pregnancy and breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
An overdose can cause nausea, vomiting, diarrhoea, constipation and abdominal discomfort.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep this medicine below 30° C, in a dry place and away from light. Keep it out of the reach of children.
Drug Interactions
Common questions about Synogen B 20 mg+750 mg+50 mg+0.75 mg
What is Synogen B 20 mg+750 mg+50 mg+0.75 mg Tablet?
Synogen B 20 mg+750 mg+50 mg+0.75 mg Tablet is a medicine that contains Undenatured Type II Collagen + Glucosamine sulfate + Boswellia serrata + Boron. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Specific mineral & vitamin combined preparations group of medicines.
What is Synogen B used for?
Undenatured Type II Collagen + Glucosamine sulfate + Boswellia serrata + Boron tablet is used to give superior support to aging joints. It's a next-generation, multi-nutrient formula based on the latest research.
What are the side effects of Synogen B?
Glucosamine sulfate seems to be safe for most people. When side effects do occur, they are usually mild and include nausea, heartburn, diarrhea and constipation.
Can I take Synogen B during pregnancy or while breastfeeding?
This combination is not recommended during pregnancy and breastfeeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Synogen B?
An overdose can cause nausea, vomiting, diarrhoea, constipation and abdominal discomfort. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Synogen B?
Keep this medicine below 30° C, in a dry place and away from light. Keep it out of the reach of children.
Can I take other medicines with Synogen B?
Some medicines can interact with Undenatured Type II Collagen + Glucosamine sulfate + Boswellia serrata + Boron, for example: Glucosamine, Undenatured Type II Collagen, Heparin Sodium, Warfarin Sodium. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Joinflex-M by Aristopharma Limited has the same ingredient and strength for ৳30.00 per unit, compared with ৳35.00 for Synogen B. Ask your doctor or pharmacist before switching.
Do I need a prescription for Synogen B?
Synogen B is a prescription (Rx) medicine. Take it as your doctor advises.