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Same active ingredient — pay up to 47% less
These brands contain the same active ingredient (Amlodipine Besilate + Atorvastatin). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Syncard
Other strengths and forms by Incepta Pharmaceuticals Ltd.
Indications & Uses
Syncard is indicated for:
Pharmacology
This is a combination product of Amlodipine Besilate and Atorvastatin. Each tablet contains Amlodipine Besilate BP equivalent to 5 mg Amlodipine, which is a calcium channel blocker, and Atorvastatin calcium INN equivalent to 10 mg Atorvastatin, which is a statin (HMG-CoA reductase inhibitor).
Amlodipine is a peripheral arterial vasodilator. It acts directly on vascular smooth muscle, so peripheral vascular resistance falls and blood pressure comes down.
Atorvastatin calcium is a synthetic lipid-lowering agent. It inhibits 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate. This is an early and rate-limiting step in the synthesis of cholesterol.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Amlodipine: the usual starting dose for high blood pressure is 5 mg by mouth once daily, and the maximum is 10 mg once daily. Elderly people and patients with hepatic insufficiency may be started on 2.5 mg once daily. That same 2.5 mg dose may be used when amlodipine is added to other antihypertensive treatment. The dose should be adjusted to each patient's need. For chronic stable or vasospastic angina, the recommended dose is 5 to 10 mg, and the lower dose is suggested in the elderly and in patients with hepatic insufficiency.
Atorvastatin: the patient should be placed on a standard cholesterol-lowering diet before starting atorvastatin and should stay on that diet during treatment.
Hypercholesterolemia (Heterozygous Familial and Nonfamilial) and Mixed Dyslipidemia (Fredrickson Types IIa and IIb)
The recommended starting dose of atorvastatin is 10 mg daily. The dosage range is 10 to 80 mg once daily. It can be taken as a single dose at any time of the day, with or without food.
Homozygous Familial Hypercholesterolemia
In patients with homozygous FH, the dose of atorvastatin is 10 to 80 mg daily.
Patients with renal insufficiency
Renal disease has no influence on the plasma concentrations or lipid effects of atorvastatin, so no dose adjustment is required. Hemodialysis isn't expected to raise the clearance of atorvastatin much, because the drug is heavily bound to plasma proteins.
Patients with hepatic dysfunction
In patients with moderate to severe hepatic dysfunction, the therapeutic response to atorvastatin is unaffected, but exposure to the drug is greatly increased.
Side Effects
Amlodipine General The vasodilatation from Amlodipine comes on gradually, so acute hypotension has rarely been reported after oral use. Even so, take care when giving Amlodipine, as with any other peripheral vasodilator, particularly in patients with severe aortic stenosis. Use in Patients with Congestive Heart Failure Hemodynamic studies and a controlled trial in Class-II-III heart failure patients showed that Amlodipine did not lead to clinical deterioration, as measured by exercise tolerance, left ventricular ejection fraction and clinical symptoms. In general, though, all calcium channel blockers should be used with caution in patients with heart failure. Beta-blocker Rhabdomyolysis with acute renal failure secondary to myoglobinuria has been reported with other drugs in this class. Atorvastatin Atorvastatin may raise serum creatine phosphokinase levels, and this should be considered in the differential diagnosis of chest pain in patients taking Atorvastatin. Uncomplicated myalgia has been reported in patients treated with Atorvastatin. Stop Atorvastatin if CPK levels are markedly elevated, or if myopathy is diagnosed or suspected. Side effects Atorvastatin is generally well tolerated. The adverse effects reported commonly are constipation, flatulence, dyspepsia, abdominal pain, headache, nausea, myalgia, diarrhea, asthenia and insomnia.
Cautions & Contraindications
Warnings & Precautions
Increased angina and/or myocardial infarction With Amlodipine Besilate + Atorvastatin, rarely, patients have developed documented increases in the frequency, duration and/or severity of angina, or an acute myocardial infarction, on starting calcium channel blocker therapy or when the dose was increased. This has been seen particularly in patients with severe obstructive coronary artery disease. The mechanism of this effect has not been elucidated. Liver dysfunction HMG-CoA reductase inhibitors, like some other lipid-lowering therapies, have been associated with biochemical abnormalities of liver function. Precautions Amlodipine General: The vasodilatation caused by Amlodipine comes on gradually, so acute hypotension after oral use has rarely been reported. Even so, take care when giving Amlodipine, as with any other peripheral vasodilator, particularly in patients with severe aortic stenosis. Use in patients with congestive heart failure: Haemodynamic studies and a controlled trial in Class II to III heart failure patients showed that Amlodipine did not lead to clinical deterioration, as measured by exercise tolerance, left ventricular ejection fraction and clinical symptoms. In general, though, all calcium channel blockers should be used with caution in patients with heart failure. Atorvastatin Rhabdomyolysis with acute renal failure secondary to myoglobinuria has been reported with other drugs in this class. Atorvastatin may raise serum creatine phosphokinase levels, and this should be considered in the differential diagnosis of chest pain in patients on Atorvastatin therapy. Uncomplicated myalgia has been reported in patients treated with Atorvastatin. Stop Atorvastatin therapy if CPK levels are markedly elevated, or if myopathy is diagnosed or suspected.
Contraindications
Amlodipine Besilate + Atorvastatin must not be used in people who are known to be hypersensitive to amlodipine. For the atorvastatin part, it must not be used in anyone who is hypersensitive to any component of this medicine. It is also contraindicated in active liver disease, and where serum transaminases stay raised for no known reason and exceed three times the upper limit of normal.
Pregnancy & Breastfeeding
Safety of Amlodipine Besilate + Atorvastatin in pregnancy has not been established. Using HMG-CoA reductase inhibitors while breastfeeding is not recommended.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Children: the safety and efficacy of Atorvastatin haven't been established in children. Older patients: at the recommended doses, Atorvastatin works and is tolerated in much the same way as it is in the general population.
Storage
Keep Amlodipine Besilate + Atorvastatin in a cool, dry place, away from light and moisture. As with all medicines, keep it out of the reach of children.
Drug Interactions
Common questions about Syncard 5 mg+10 mg
What is Syncard 5 mg+10 mg Tablet?
Syncard 5 mg+10 mg Tablet is a medicine that contains Amlodipine Besilate + Atorvastatin. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Anti-anginal & lipid lowering drugs group of medicines.
What is Syncard used for?
Syncard is used for: Hypertension, Angina Pectoris, Heart Failure, Hyperlipidemia, Stroke, Diabetes Mellitus, Hypothyroidism.
What are the side effects of Syncard?
Amlodipine General The vasodilatation from Amlodipine comes on gradually, so acute hypotension has rarely been reported after oral use. Even so, take care when giving Amlodipine, as with any other peripheral vasodilator, particularly in patients with severe aortic stenosis.
Can I take Syncard during pregnancy or while breastfeeding?
Safety of Amlodipine Besilate + Atorvastatin in pregnancy has not been established. Using HMG-CoA reductase inhibitors while breastfeeding is not recommended. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Syncard?
Keep Amlodipine Besilate + Atorvastatin in a cool, dry place, away from light and moisture. As with all medicines, keep it out of the reach of children.
Can I take other medicines with Syncard?
Some medicines can interact with Amlodipine Besilate + Atorvastatin, for example: Cyclosporine, Erythromycin, Niacin, Atorvastatin, Digoxin, Amlodipine. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
ATV Plus by Delta Pharma PLC. has the same ingredient and strength for ৳8.00 per unit, compared with ৳15.00 for Syncard. Ask your doctor or pharmacist before switching.
Do I need a prescription for Syncard?
Syncard is a prescription (Rx) medicine. Take it as your doctor advises.