Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →More from Sympres
Other strengths and forms by Eskayef Pharmaceuticals Ltd.
Indications & Uses
Sympres is indicated for:
Pharmacology
Moxonidine has shown relatively potent antihypertensive activity across various animal models. Available experimental evidence indicates that its site of action lies within the central nervous system (CNS). The drug binds to I1 imidazoline receptors and, to a lesser extent, a2-adrenoreceptors. Its therapeutic effect appears to arise from interaction with I1 receptors in the rostral ventrolateral medulla, which reduces sympathetic nerve activity. Unlike other centrally acting antihypertensives, Moxonidine shows only low affinity for central a2-adrenoceptors relative to I1 imidazoline receptors; a2-adrenoceptors are thought to be the molecular target responsible for sedation and dry mouth, the most common side effects seen with this class of drugs. In humans, Moxonidine reduces systemic vascular resistance and, as a result, lowers arterial blood pressure.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Treatment should begin with 200 micrograms taken in the morning. After three weeks, the dose can be raised to 400 micrograms, given either as one dose or split into a morning and an evening dose, until you get a satisfactory response. If the response is still not good enough after a further 3 weeks of treatment, the dose can be increased to a maximum of 600 micrograms, divided into a morning and an evening dose. A single dose of 400 micrograms and a daily dose of 600 micrograms of Moxonidine should not be exceeded. Moxonidine can be taken with or without food.
Side Effects
Moxonidine can cause asthenia, headache, pain, abdominal pain, back pain, dizziness, dry mouth, somnolence and vertigo.
Cautions & Contraindications
Warnings & Precautions
Cessation of combination therapy with beta-blockers: Stopping combination therapy with Sympres and a beta-blocker suddenly may cause rebound hypertension. If this combination therapy needs to be stopped, the beta-blocker should be withdrawn first, with Sympres discontinued a few days later. Blood pressure should be monitored regularly throughout the withdrawal period. Atrioventricular block: Cases of varying degrees of AV block have been reported after Sympres treatment in real-world use following marketing. Based on these reports, a role for Sympres in delaying atrioventricular conduction cannot be completely ruled out. Caution is therefore recommended when treating patients who may be predisposed to AV block. In patients with 1st degree AV block, special care should be taken to avoid bradycardia, and Sympres must not be used in higher degree AV blocks. Since Sympres is excreted mainly through the kidneys, it should be given with caution to patients with renal impairment, and the dose should be carefully titrated in these patients, particularly at the start of treatment. This product should not be taken by patients with rare hereditary conditions such as galactose intolerance, total lactose deficiency, or glucose-galactose malabsorption.
Contraindications
Don't use moxonidine if you're hypersensitive to any of its components, or if you have sick sinus syndrome. The same applies to bradycardia (a resting heart rate below 50 beats/minute), 2nd or 3rd degree AV-block, and cardiac insufficiency.
Pregnancy & Breastfeeding
Pregnancy Category: B3. Research on the use of moxonidine during pregnancy is limited. Studies in animals have revealed effects on the developing embryo, so moxonidine should be avoided in pregnancy unless the potential benefit is judged to outweigh the possible risk to the baby. Because moxonidine passes into breast-milk, it is not recommended for breastfeeding mothers. If treatment with moxonidine is felt to be necessary, breastfeeding should be discontinued.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Moxonidine at a temperature not above 25°C. Keep it away from light and from wet places. Keep it out of reach of children.
Drug Interactions
Common questions about Sympres 0.2 mg
What is Sympres 0.2 mg Tablet?
Sympres 0.2 mg Tablet is a medicine that contains Moxonidine. It is made by Eskayef Pharmaceuticals Ltd. It belongs to the Anti-hypertensive group of medicines.
What is Sympres used for?
Sympres is used for: Hypertension.
What are the side effects of Sympres?
Moxonidine can cause asthenia, headache, pain, abdominal pain, back pain, dizziness, dry mouth, somnolence and vertigo.
Can I take Sympres during pregnancy or while breastfeeding?
Pregnancy Category: B3. Research on the use of moxonidine during pregnancy is limited. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Sympres?
Store Moxonidine at a temperature not above 25°C. Keep it away from light and from wet places.
Can I take other medicines with Sympres?
Some medicines can interact with Moxonidine, for example: Lorazepam. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Sympres is already among the lowest-priced brands of Moxonidine at this strength.
Do I need a prescription for Sympres?
Sympres is a prescription (Rx) medicine. Take it as your doctor advises.