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Same active ingredient — pay up to 1% less
These brands contain the same active ingredient (Glimepiride). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Stimulin
Other strengths and forms by Orion Pharma Ltd.
Indications & Uses
Stimulin is indicated for:
Pharmacology
Glimepiride is a sulfonylurea antidiabetic agent that lowers blood glucose concentration. Its primary mechanism of action appears to depend on stimulating insulin release from functioning pancreatic beta cells. Glimepiride works together with glucose by improving the sensitivity of beta cells to the body's natural glucose stimulus, which leads to insulin secretion. Extrapancreatic effects, such as reduced basal hepatic glucose production and increased peripheral tissue sensitivity to insulin and glucose uptake, may also contribute to Glimepiride's activity. In non-fasting diabetic patients, the blood glucose-lowering effect of a single dose of Glimepiride lasts for 24 hours.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
In principle, the dose of Glimepiride depends on the blood sugar level you are aiming for. It must be the lowest dose that is enough to reach the desired metabolic control. Both the starting dose and the maintenance dose are set from regular checks of glucose in blood and urine. These checks also help detect primary or secondary failure of therapy.
Initial dose and dose titration
The usual starting dose is 1 mg once daily. If needed, the daily dose can be increased. Any increase should be based on regular blood sugar monitoring and made gradually, at intervals of 1 to 2 weeks, in these steps: 1 mg -> 2 mg -> 3 mg -> 4 mg -> 6 mg.
Dose in patients with well controlled diabetes
The usual range for patients whose diabetes is well controlled is 1 to 4 mg daily.
Distribution of doses
The physician decides the timing and distribution of doses, taking the patient's current life-style into account. A single daily dose is normally enough. Take it immediately before a substantial breakfast, or, if no breakfast is taken, immediately before the first main meal. It is very important not to skip meals after taking the medicine.
Secondary dosage adjustment
As diabetes control improves, sensitivity to insulin rises, so the Glimepiride requirement may fall as treatment goes on. To avoid hypoglycaemia, a timely dose reduction or stopping Glimepiride must be considered. A dose adjustment should also be considered whenever the patient's weight or life-style changes, or when other factors make the patient more prone to hypoglycaemia or hyperglycaemia.
Changeover from other oral antidiabetics to Glimepiride
There is no exact dose relationship between Glimepiride and other oral blood sugar lowering agents. When Glimepiride replaces one of them, the starting daily dose is 1 mg. This holds even when the patient was on the maximum dose of the other agent. Any later increase should follow the guideline given above under initial dose and dose titration. The potency and duration of action of the previous agent must be considered. It may be necessary to interrupt treatment to avoid additive effects, which would raise the risk of hypoglycaemia.
Side Effects
Low blood sugar, temporary blurred vision, nausea, vomiting, diarrhoea, stomach pain, hives, and a drop in blood pressure.
Cautions & Contraindications
Warnings & Precautions
In the first few weeks of treatment, the risk of hypoglycaemia may be higher, so blood sugar should be monitored closely during this period. If this risk is present, your doctor may need to adjust your Glims dose. Hypoglycaemia can usually be brought under control quickly by taking carbohydrates right away, such as glucose or sugar.
Contraindications
Glimepiride is not suitable for treating insulin-dependent (type I) diabetes mellitus, diabetic ketoacidosis, or diabetic coma. It must not be used in patients who are hypersensitive to Glimepiride, other sulfonylureas, or other sulfonamides, nor in patients with severe hepatic dysfunction, severe renal impairment, or those on dialysis.
Pregnancy & Breastfeeding
Glimepiride must not be taken during pregnancy; switching to insulin is necessary. Patients who are planning a pregnancy should inform their physician and switch over to insulin. Glimepiride can pass into breast milk and may harm a nursing child. For this reason, breastfeeding women must not take Glimepiride; either the mother should switch to insulin, or breastfeeding should be stopped entirely.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Taking too much of a sulfonylurea, Glimepiride included, can cause hypoglycaemia. If the symptoms are mild, with no loss of consciousness and no neurologic findings, treat them aggressively with oral glucose, and adjust the dose of the medicine or the meal pattern. Keep monitoring closely until the physician is sure the patient is out of danger.
Severe hypoglycaemic reactions with coma, seizure or other neurological impairment don't happen often, but they are medical emergencies and the patient needs to go to hospital immediately. If hypoglycaemic coma is diagnosed or suspected, give a rapid intravenous injection of concentrated (50%) glucose solution. Follow this with a continuous infusion of a more dilute (10%) glucose solution, at a rate that keeps the blood glucose above 100 mg/dl.
Monitor the patient closely for a minimum of 24 to 48 hours, because hypoglycaemia may come back after the patient seems to have recovered.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Glimepiride at or below 30°C, and keep it away from light. Keep it out of the reach of children.
Drug Interactions
Common questions about Stimulin 2 mg
What is Stimulin 2 mg Tablet?
Stimulin 2 mg Tablet is a medicine that contains Glimepiride. It is made by Orion Pharma Ltd. It belongs to the Sulfonylureas group of medicines.
What is Stimulin used for?
Stimulin is used for: Type 2 Diabetes Mellitus, Diabetes Mellitus.
What are the side effects of Stimulin?
Low blood sugar, temporary blurred vision, nausea, vomiting, diarrhoea, stomach pain, hives, and a drop in blood pressure.
Can I take Stimulin during pregnancy or while breastfeeding?
Glimepiride must not be taken during pregnancy; switching to insulin is necessary. Patients who are planning a pregnancy should inform their physician and switch over to insulin. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Stimulin?
Taking too much of a sulfonylurea, Glimepiride included, can cause hypoglycaemia. If the symptoms are mild, with no loss of consciousness and no neurologic findings, treat them aggressively with oral glucose, and adjust the dose of the medicine or the meal pattern. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Stimulin?
Store Glimepiride at or below 30°C, and keep it away from light. Keep it out of the reach of children.
Can I take other medicines with Stimulin?
Some medicines can interact with Glimepiride, for example: Fluconazole, Isoniazid, Chloramphenicol, Rifampicin, Cyclophosphamide, Disopyramide. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Adglim by Unimed Unihealth Pharmaceuticals Ltd. has the same ingredient and strength for ৳5.00 per unit, compared with ৳5.03 for Stimulin. Ask your doctor or pharmacist before switching.
Do I need a prescription for Stimulin?
Stimulin is a prescription (Rx) medicine. Take it as your doctor advises.