Indications & Uses
Yellow Fever Vaccine (Stamaril) protects against yellow fever, a serious infectious disease. Yellow fever occurs in certain areas of the world and spreads to people through the bites of infected mosquitoes. The vaccine is given to people who are travelling to, passing through or living in an area where yellow fever occurs. It is also given to people travelling to any country that requires an International Certificate of Vaccination for entry (this may depend on the countries previously visited during the same trip), and to people who may handle infectious materials, such as laboratory workers. To get a valid vaccination certificate against yellow fever, you must be vaccinated at an approved vaccination centre by a qualified and trained healthcare professional, so that an International Certificate of Vaccination can be issued. The certificate is valid from 10 days after the first dose of vaccine. In some circumstances, when a booster is needed, the certificate (see Section 3) is valid immediately after the injection.
Pharmacology
Yellow Fever Vaccine is a live, attenuated virus vaccine. It stimulates active immunity to yellow fever by prompting the body to make its own antibodies. The vaccine is used for active immunisation against yellow fever. Each dose (usually 0.5 ml) contains at least 1000 mouse LD50 units.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Yellow Fever Vaccine is given as a single dose of 0.5 millilitre to adults and to children from 6 months of age. The first dose should go in at least 10 days before you need protection from yellow fever, because the vaccine takes 10 days to work and give good protection against the yellow fever virus. This protection is expected to last at least 10 years and may last for life.
In some situations a booster of one dose (0.5 millilitre) may be needed. This is the case if you or your child did not respond well enough to the first dose and you or your child are still at risk of yellow fever virus infection, or if official recommendations call for it.
Yellow Fever Vaccine is given as an injection by a qualified and trained healthcare professional. It is usually injected just underneath the skin, but it can be given into a muscle. It must not be injected into a blood vessel.
Side Effects
Some serious side effects have been reported with the Yellow Fever Vaccine. These are allergic reactions, which can show up as a rash, itching or hives on the skin, swelling of the face, lips, tongue or other parts of the body, difficulty swallowing or breathing, and loss of consciousness.
Cautions & Contraindications
Warnings & Precautions
Tell your doctor if any of the points below apply to you or your child, and ask them to explain anything you don't understand. Before you have Yellow Fever Vaccine, you need a risk assessment with a trained health professional, so that it can be decided whether you should receive it. People over 60 years old, and children less than 9 months old, have an increased risk of certain severe but rare reactions to the vaccine. These include serious reactions that affect the brain and nerves, and the major organs. You will only be given the vaccine when the risk of infection with the virus is well established in the countries where you are going to stay. A child aged 6 to 9 months may be given Yellow Fever Vaccine only in special situations and on the basis of current official advice. You or your child may be infected by the HIV virus but have no active symptoms from the infection. In that case your doctor will advise whether the vaccine can be given, based on the results of laboratory tests and specialist advice. A bleeding disorder (such as haemophilia or a low level of platelets), or taking any medicine that stops the blood clotting normally, doesn't rule out the vaccine. You can still be given it, provided it is injected under the skin and not into muscle. Any allergic reaction to latex should be mentioned too, because the tip cap of the pre-filled syringe contains a natural rubber latex derivative which may cause an allergic reaction.
Contraindications
Don't use Yellow Fever Vaccine if you or your child are allergic to the active substance, to any of the other ingredients of the vaccine (listed in Section 6), or to eggs or chicken proteins. Don't use it either if you or your child have had a severe allergic reaction after a previous dose of any yellow fever vaccine, or if the child is less than 6 months old. The vaccine must also not be given if you or your child have a poor or weakened immune system for any reason, such as an illness or medical treatments (for example high-dose steroids, any other medicines that affect the immune system, or chemotherapy). If you aren't sure whether a medicine may affect your or your child's immune system, talk to your doctor before the vaccine is given. It must not be given if the immune system is weakened because of HIV infection. Your doctor will advise whether you or your child can still receive Yellow Fever Vaccine, based on the results of your blood tests. It must also not be given if you or your child are infected with HIV and have active symptoms of the infection. Don't use the vaccine if you or your child have a history of problems with the thymus gland, or have had the thymus gland removed for any reason. If you or your child have an illness with a high or moderate fever, or any acute illness, the vaccination will be postponed until you or your child have recovered.
Pregnancy & Breastfeeding
If you are pregnant, breastfeeding, think you may be pregnant or are planning a baby, talk to your doctor before you have Yellow Fever Vaccine. You should not receive it during pregnancy or breastfeeding unless this cannot be avoided. It is also recommended that you do not become pregnant within one month after the vaccine.
Your doctor can tell you whether you really need to be vaccinated. If vaccination is needed, it is recommended to stop breastfeeding for at least 2 weeks after you receive Yellow Fever Vaccine. And if you have already received the vaccine while pregnant or breastfeeding, consult your doctor.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Yellow Fever Vaccine out of the sight and reach of children. Don't use it after the expiry date printed on the carton after EXP. The expiry date means the last day of that month. Store the vaccine in a refrigerator (2°C to 8°C) and do not freeze it.
Drug Interactions
Common questions about Stamaril 1000 IU/0.5 ml
What is Stamaril 1000 IU/0.5 ml IM/SC Injection?
Stamaril 1000 IU/0.5 ml IM/SC Injection is a medicine that contains Yellow Fever Vaccine. It is made by Synovia Pharma PLC. It belongs to the Vaccines group of medicines.
What is Stamaril used for?
Yellow Fever Vaccine (Stamaril) protects against yellow fever, a serious infectious disease. Yellow fever occurs in certain areas of the world and spreads to people through the bites of infected mosquitoes.
What are the side effects of Stamaril?
Some serious side effects have been reported with the Yellow Fever Vaccine. These are allergic reactions, which can show up as a rash, itching or hives on the skin, swelling of the face, lips, tongue or other parts of the body, difficulty swallowing or breathing, and loss of consciousness.
Can I take Stamaril during pregnancy or while breastfeeding?
If you are pregnant, breastfeeding, think you may be pregnant or are planning a baby, talk to your doctor before you have Yellow Fever Vaccine. You should not receive it during pregnancy or breastfeeding unless this cannot be avoided. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Stamaril?
Keep Yellow Fever Vaccine out of the sight and reach of children. Don't use it after the expiry date printed on the carton after EXP.
Can I take other medicines with Stamaril?
Some medicines can interact with Yellow Fever Vaccine, for example: Measles Vaccine (Live). Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Stamaril?
Stamaril is a prescription (Rx) medicine. Take it as your doctor advises.