Save on this medicine
Other brands with the same active ingredient
These brands contain the same active ingredient (Sofosbuvir). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Sofo-C is indicated for:
Pharmacology
Sofosbuvir is a nucleotide analog inhibitor that specifically blocks the HCV NS5B RNA-dependent RNA polymerase, an enzyme the hepatitis C virus needs to copy its genetic material. Once inside cells, sofosbuvir is metabolized into its active form, a uridine analog triphosphate (GS-461203). This active form is then incorporated into the growing HCV RNA chain by the NS5B polymerase, where it acts as a chain terminator, stopping further RNA synthesis. More specifically, sofosbuvir binds to the two Mg2+ ions located in the GDD active site motif of the NS5B polymerase, and by doing so, it blocks the enzyme's activity and prevents the virus from replicating further.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual dose of Sofosbuvir is one 400 mg tablet once a day, with or without food. It should be given together with Ribavirin, or together with Pegylated Interferon and Ribavirin, for the treatment of CHC.
The recommended combinations are the same for HCV mono-infected patients and for HCV/HIV-1 co-infected patients:
Genotype 1 or 4: Sofosbuvir with Peginterferon alfa and Ribavirin for 12 weeks.
Genotype 2: Sofosbuvir with Ribavirin for 12 weeks.
Genotype 3: Sofosbuvir with Ribavirin for 24 weeks.
For CHC patients with genotype 1 infection who are not eligible for Interferon, Sofosbuvir with Ribavirin for 24 weeks can be considered.
In patients with hepatocellular carcinoma who are waiting for a liver transplant, Sofosbuvir should be used with Ribavirin. Treatment can continue for up to 48 weeks, or until the transplant takes place, whichever comes first.
A dose recommendation cannot be made for patients with severe renal impairment or end stage renal disease.
Side Effects
Common side effects with Buviren plus Ribavirin (occurring in 20% or more of patients, all severity levels) were fatigue and headache. When Buviren was combined with Peginterferon alfa and Ribavirin, patients more often reported fatigue, headache, nausea, insomnia, anemia, itching, weakness, rash, reduced appetite, chills, flu-like symptoms, fever, diarrhea, low neutrophil counts, muscle aches, and irritability.
Cautions & Contraindications
Warnings & Precautions
Bradycardia with amiodarone: Combining amiodarone with Buviren and another direct-acting antiviral (DAA) can cause serious, symptomatic slowing of the heart rate. This risk is higher in patients who are also on beta blockers, or who have underlying heart conditions and/or advanced liver disease. For this reason, giving amiodarone alongside Buviren plus another DAA is not recommended. If no other treatment option is available, heart function should be monitored closely.
Contraindications
When Sofosbivur is used together with Ribavirin, or with Peginterferon alfa/Ribavirin, the contraindications of those other medicines apply to the combination as well. Sofosbuvir combined with Ribavirin or Peginterferon alfa/Ribavirin must not be used in women who are pregnant or may become pregnant, or in men whose female partners are pregnant. The reason is the risk of birth defects and fetal death linked to Ribavirin.
Pregnancy & Breastfeeding
During pregnancy (Category B), there are no adequate and well-controlled studies of sofosbuvir in pregnant women. For nursing mothers, it is not known whether sofosbuvir and its metabolites pass into human breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric Use: Safety and effectiveness of Sofosbuvir haven't been established in children under 18 years of age.
Geriatric Use: Sofosbuvir was given to 90 subjects aged 65 and over. Their response rates were similar to those of younger subjects across the treatment groups. No dose adjustment of Sofosbuvir is needed in elderly patients.
Overdose
The highest dose of Sofosbuvir studied was a single dose of 1200 mg. There is no specific antidote for an overdose. Treatment is general supportive care, which means monitoring the patient's vital signs and watching their clinical status.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Sofosbuvir in a cool, dry place and keep it away from light. Always keep it out of the reach of children.
Drug Interactions
Common questions about Sofo-C 400 mg
What is Sofo-C 400 mg Tablet?
Sofo-C 400 mg Tablet is a medicine that contains Sofosbuvir. It is made by Aristopharma Limited. It belongs to the Hepatic viral infections (Hepatitis C) group of medicines.
What is Sofo-C used for?
Sofo-C is used for: Cancer.
What are the side effects of Sofo-C?
Common side effects with Buviren plus Ribavirin (occurring in 20% or more of patients, all severity levels) were fatigue and headache. When Buviren was combined with Peginterferon alfa and Ribavirin, patients more often reported fatigue, headache, nausea, insomnia, anemia, itching, weakness, rash, reduced appetite, chills, flu-like symptoms, fever, diarrhea, low neutrophil counts, muscle aches, and irritability.
Can I take Sofo-C during pregnancy or while breastfeeding?
During pregnancy (Category B), there are no adequate and well-controlled studies of sofosbuvir in pregnant women. For nursing mothers, it is not known whether sofosbuvir and its metabolites pass into human breast milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Sofo-C?
The highest dose of Sofosbuvir studied was a single dose of 1200 mg. There is no specific antidote for an overdose. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Sofo-C?
Store Sofosbuvir in a cool, dry place and keep it away from light. Always keep it out of the reach of children.
Can I take other medicines with Sofo-C?
Some medicines can interact with Sofosbuvir, for example: Ledipasvir + Sofosbuvir, Carbamazepine, Rifampicin, Oxcarbazepine, St. John's Wort, Phenytoin. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Sofo-C?
Sofo-C is a prescription (Rx) medicine. Take it as your doctor advises.