More from Simplaqor
Other strengths and forms by Nevian Lifescience PLC
Indications & Uses
Simplaqor is indicated for:
Pharmacology
Simvastatin is a cholesterol-lowering medicine. It works mainly by blocking an enzyme called HMG-CoA reductase. When that enzyme is blocked, the liver cells grow more LDL receptors on their surface. These receptors pull more LDL cholesterol out of the blood, so the body clears it faster and breaks it down more. Simvastatin also lowers very low-density lipoprotein (VLDL) cholesterol, and it cuts down how much LDL is formed from VLDL. The drug is broken down heavily in the liver, which is also where it does most of its work.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Before starting Simvastatin, the patient should be placed on a standard cholesterol lowering diet, and this diet should be continued throughout treatment. The usual starting dose is 10 mg per day, taken as a single dose in the evening. If the dose needs to be adjusted, this should be done at intervals of at least four weeks, up to a maximum of 40 mg daily taken as a single dose in the evening. If LDL-cholesterol falls below 2 mmol/L or total plasma cholesterol falls below 3.5 mmol/L, reducing the dose of Simvastatin should be considered. In hypercholesterolemia, the recommended starting dose is 5 to 10 mg once a day in the evening, and the recommended dosing range is 5 to 40 mg per day taken as a single dose in the evening. In patients with coronary heart disease and hypercholesterolemia, the starting dose should be 20 mg once a day in the evening. Because Simvastatin is not excreted through the kidneys to any significant extent, dose adjustment should not be necessary in patients with renal insufficiency. Safety and effectiveness in children and adolescents have not been established.
Side Effects
Vastocor is generally well tolerated. Reported side effects include headache, fatigue, insomnia, and gastrointestinal effects such as nausea, constipation or diarrhoea, flatulence, dyspepsia, and abdominal cramps, as well as muscular effects such as myalgia, myositis, and myopathy. Rare cases of rhabdomyolysis with acute renal failure secondary to myoglobinuria have been associated with Vastocor therapy. Hepatitis, pancreatitis, rash, and angio-oedema have also been reported. No potentially life-threatening effects have been reported.
Cautions & Contraindications
Warnings & Precautions
Use with caution in patients with a history of liver disease and in those who consume large amounts of alcohol. Liver function tests should be performed before starting treatment and periodically during treatment. If serum transaminase levels rise to three times the upper limit of normal, treatment should be discontinued. Pregnancy should be avoided during treatment and for one month after stopping it.
Contraindications
Simvastatin should not be used in active liver disease; in pregnant and breastfeeding mothers; in women of child-bearing age unless they are adequately protected by contraception; in patients with hypersensitivity to any component of the preparation; or in patients with homozygous familial hypercholesterolaemia who have a complete absence of LDL receptors.
Pregnancy & Breastfeeding
Category X: Animal studies or human data have shown clear evidence of foetal harm, and this risk outweighs any potential benefit of the drug. It should not be used by women who are pregnant or may become pregnant.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
No data are available on overdose with Simvastatin, and there is no antidote. If an overdose happens, general measures should be taken and liver function should be monitored.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Simvastatin in a cool, dry place, away from light. Keep it out of the reach of children.
Drug Interactions
Common questions about Simplaqor 40 mg
What is Simplaqor 40 mg Tablet?
Simplaqor 40 mg Tablet is a medicine that contains Simvastatin. It is made by Nevian Lifescience PLC. It belongs to the Other Anti-anginal & Anti-ischaemic drugs group of medicines.
What is Simplaqor used for?
Simplaqor is used for: Hyperlipidemia.
What are the side effects of Simplaqor?
Vastocor is generally well tolerated. Reported side effects include headache, fatigue, insomnia, and gastrointestinal effects such as nausea, constipation or diarrhoea, flatulence, dyspepsia, and abdominal cramps, as well as muscular effects such as myalgia, myositis, and myopathy.
Can I take Simplaqor during pregnancy or while breastfeeding?
Category X: Animal studies or human data have shown clear evidence of foetal harm, and this risk outweighs any potential benefit of the drug. It should not be used by women who are pregnant or may become pregnant. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Simplaqor?
No data are available on overdose with Simvastatin, and there is no antidote. If an overdose happens, general measures should be taken and liver function should be monitored. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Simplaqor?
Keep Simvastatin in a cool, dry place, away from light. Keep it out of the reach of children.
Can I take other medicines with Simplaqor?
Some medicines can interact with Simvastatin, for example: Ticagrelor, Clarithromycin, Itraconazole, Bempedoic Acid, Bempedoic Acid + Ezetimibe, Lopinavir + Ritonavir. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Simplaqor?
Simplaqor is a prescription (Rx) medicine. Take it as your doctor advises.