Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →Save on this medicine
Same active ingredient — pay up to 50% less
These brands contain the same active ingredient (Cetirizine Hydrochloride). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Silatrol is indicated for:
Pharmacology
Cetirizine Hydrochloride is a potent H1 receptor antagonist, and it has no significant anticholinergic or antiserotonic effects. At pharmacologically active doses it causes almost no drowsiness and doesn't cause behavioural changes. It inhibits the histamine-mediated early phase of the allergic reaction. It also reduces the migration of inflammatory cells and the release of mediators linked to the late phase of the allergic reaction. Pharmacokinetics: a 10 mg dose of cetirizine reaches peak plasma concentrations of 257 mcg/L within one hour (980 mcg/L in children). Food doesn't affect the extent of absorption, but it may slightly reduce the rate. Peak blood levels of 0.3 micrograms/ml are reached between thirty and sixty minutes after a 10 mg dose. The plasma half-life is approximately 11 hours, and absorption is very consistent from one person to the next. Renal clearance is 30 ml/minute and the excretion half-life is approximately nine hours.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Cetirizine oral dosage form: adults and children 6 years and older take 1 tablet or 2 teaspoonfuls daily (or 1 teaspoonful twice daily). Children 2 to 6 years take 1 teaspoonful once daily or 1/2 teaspoonful twice daily. Children 6 months to 2 years take 1/2 teaspoonful once daily. For children 12 to 23 months of age, the dose can be raised to a maximum of 1/2 teaspoonful every 12 hours.
Cetirizine injectable dosage form: this is a single use injectable product for intravenous use only. The recommended regimen is once every 24 hours as needed for treatment of acute urticaria. Give Cetirizine as an intravenous push over 1 to 2 minutes. It is not recommended in paediatric patients less than 6 years of age with impaired renal or hepatic function.
Adults and adolescents 12 years of age and older: the recommended dose is 10 mg by intravenous injection. Children 6 to 11 years of age: the recommended dose is 5 mg or 10 mg by intravenous injection, depending on how severe the symptoms are. Children 6 months to 5 years of age: the recommended dose is 2.5 mg by intravenous injection.
Side Effects
Somnolence, which means feeling sleepy or drowsy, is the side effect people report most often with Cetirizine Hydrochloride.
Cautions & Contraindications
Warnings & Precautions
Take care when you drive a car or work with heavy machinery while using cetirizine hydrochloride.
Contraindications
Cetirizine Hydrochloride should not be given to anyone who has had a hypersensitivity reaction to Cetirizine or to hydroxyzine.
Pregnancy & Breastfeeding
Cetirizine Hydrochloride falls under US FDA Pregnancy Category B. That said, there are no adequate and well-controlled studies in pregnant women. Animal reproduction studies don't always predict how humans will respond, so Cetirizine Hydrochloride should be used during pregnancy only if clearly needed.
The medicine has been shown to pass into human milk. So caution should be taken when it is given to a nursing woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
In patients with mild to moderate hepatic and renal impairment, the total body clearance of Cetirizine Hydrochloride is reduced, and the AUC and half-life increase by about 2 to 3 fold. Clearance falls in proportion to the decline in creatinine clearance. Hemodialysis does not change the plasma levels. In dialysis patients, the plasma elimination half-life is approximately 20 hours and the plasma AUC is increased by about threefold.
For children, the safety of Cetirizine Hydrochloride has been demonstrated in pediatric patients aged 6 months to 5 years.
In elderly patients the clearance is reduced, but only in proportion to the decrease in creatinine clearance.
Storage
Store Cetirizine Hydrochloride in a dry place, away from light and heat. Always keep it out of the reach of children.
Drug Interactions
Common questions about Silatrol 10 mg
What is Silatrol 10 mg Tablet?
Silatrol 10 mg Tablet is a medicine that contains Cetirizine Hydrochloride. It is made by Silco Pharmaceuticlas Ltd. It belongs to the Sedating Anti-histamine group of medicines.
What is Silatrol used for?
Silatrol is used for: Asthma, Allergic Rhinitis, Urticaria.
What are the side effects of Silatrol?
Somnolence, which means feeling sleepy or drowsy, is the side effect people report most often with Cetirizine Hydrochloride.
Can I take Silatrol during pregnancy or while breastfeeding?
Cetirizine Hydrochloride falls under US FDA Pregnancy Category B. That said, there are no adequate and well-controlled studies in pregnant women. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Silatrol?
Store Cetirizine Hydrochloride in a dry place, away from light and heat. Always keep it out of the reach of children.
Is there a cheaper medicine with the same ingredient?
Hi-Trol by Hudson Pharmaceuticals Ltd. has the same ingredient and strength for ৳1.50 per unit, compared with ৳3.00 for Silatrol. Ask your doctor or pharmacist before switching.
Do I need a prescription for Silatrol?
Silatrol is a prescription (Rx) medicine. Take it as your doctor advises.