Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →Save on this medicine
Same active ingredient — pay up to 73% less
These brands contain the same active ingredient (Neratinib Maleate). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Neratinib Maleate is a kinase inhibitor. It is used on its own as extended adjuvant treatment for adult patients with early-stage HER2-positive breast cancer, after they have finished adjuvant Trastuzumab based therapy. It is also given together with Capecitabine for adult patients with advanced or metastatic HER2-positive breast cancer. These are patients who have already received two or more anti-HER2 based regimens in the metastatic setting.
Pharmacology
Neratinib is a kinase inhibitor. It binds irreversibly to Epidermal Growth Factor Receptor (EGFR), Human Epidermal Growth Factor Receptor 2 (HER2) and HER4. Chemically, neratinib belongs to the 4-anilino quinolidine class of protein kinase inhibitors.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Detailed dosing reference is not available yet. Please follow your prescription and consult your pharmacist.
Side Effects
The most common side effects of Neratinib Maleate, reported in 5% or more of patients, depend on how it is given. When Neratinib Maleate is used as a single agent, these were reported: diarrhea, nausea, abdominal pain, fatigue, vomiting, rash, stomatitis, decreased appetite, muscle spasms, dyspepsia, raised AST or ALT, nail disorder, dry skin, abdominal distention, epistaxis, weight decrease, and urinary tract infection. When Neratinib Maleate is used together with capecitabine, these were reported: diarrhea, nausea, vomiting, decreased appetite, constipation, fatigue or asthenia, weight decrease, dizziness, back pain, arthralgia, urinary tract infection, upper respiratory tract infection, abdominal distention, renal impairment, and muscle spasms.
Cautions & Contraindications
Warnings & Precautions
Diarrhea should be managed either by dose escalation of Neratinib Maleate or by loperamide prophylaxis. If diarrhea still occurs despite the recommended prophylaxis, treat it with additional antidiarrheals, fluids and electrolytes as clinically indicated. Withhold the medicine in patients who have severe and/or persistent diarrhea. Stop it permanently in patients with Grade 4 diarrhea, or with Grade ≥2 diarrhea that occurs after maximal dose reduction. For liver effects (hepatotoxicity), withhold Neratinib Maleate in patients who have Grade 3 liver abnormalities. If the abnormalities reach Grade 4, discontinue it permanently. On embryo-fetal toxicity, Neratinib Maleate can cause fetal harm. Patients should be advised of the potential risk to a fetus and told to use effective contraception.
Contraindications
Neratinib Maleate must not be given to anyone who is known to be hypersensitive to Neratinib or to any other component of the product.
Pregnancy & Breastfeeding
Neratinib can harm an unborn baby when it is given to a pregnant woman, so pregnant women should be told about this risk to the baby. There is no data on whether Neratinib or its metabolites pass into human milk, or on what they might do to a breastfed infant or to milk production. Men and women who could have children should be advised to use effective contraception while they are taking Neratinib and for at least 1 month after the last dose.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric Use
The safety and efficacy of Neratinib Maleate in pediatric patients have not been established.
Geriatric Use
Serious adverse reactions were seen in 7.0% of patients under 65 years old in the Neratinib Maleate arm, against 5.7% in the placebo arm. In patients aged 65 years and above, the figures were 9.9% for the Neratinib Maleate arm and 8.1% for the placebo arm.
Hepatic Impairment
No dose change is recommended for patients with mild to moderate hepatic impairment (Child Pugh A or B). For patients with severe hepatic impairment, the dose of Neratinib Maleate should be reduced.
Overdose
If someone takes too much Neratinib Maleate, stop giving the medicine and start general supportive care.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Neratinib Maleate at a temperature not above 30°c. Keep it away from light, and keep it out of the reach of children.
Common questions about Signera 40 mg
What is Signera 40 mg Tablet?
Signera 40 mg Tablet is a medicine that contains Neratinib Maleate. It is made by Jenphar Bangladesh Ltd. It belongs to the Tyrosine Kinase Inhibitor group of medicines.
What is Signera used for?
Neratinib Maleate is a kinase inhibitor. It is used on its own as extended adjuvant treatment for adult patients with early-stage HER2-positive breast cancer, after they have finished adjuvant Trastuzumab based therapy.
What are the side effects of Signera?
The most common side effects of Neratinib Maleate, reported in 5% or more of patients, depend on how it is given. When Neratinib Maleate is used as a single agent, these were reported: diarrhea, nausea, abdominal pain, fatigue, vomiting, rash, stomatitis, decreased appetite, muscle spasms, dyspepsia, raised AST or ALT, nail disorder, dry skin, abdominal distention, epistaxis, weight decrease, and urinary tract infection.
Can I take Signera during pregnancy or while breastfeeding?
Neratinib can harm an unborn baby when it is given to a pregnant woman, so pregnant women should be told about this risk to the baby. There is no data on whether Neratinib or its metabolites pass into human milk, or on what they might do to a breastfed infant or to milk production. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Signera?
If someone takes too much Neratinib Maleate, stop giving the medicine and start general supportive care. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Signera?
Store Neratinib Maleate at a temperature not above 30°c. Keep it away from light, and keep it out of the reach of children.
Is there a cheaper medicine with the same ingredient?
Hercent by Incepta Pharmaceuticals Ltd. has the same ingredient and strength for ৳120.00 per unit, compared with ৳450.00 for Signera. Ask your doctor or pharmacist before switching.
Do I need a prescription for Signera?
Signera is a prescription (Rx) medicine. Take it as your doctor advises.