Pricing
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Indications & Uses
Sentix is indicated for:
Pharmacology
Flupentixol Dihydrochloride is a low dose neuroleptic from the thioxanthene group. At low doses (up to 3 mg/day), flupentixol has an anxiolytic, antidepressive and mood stabilizing effect, and it also has certain activating properties. It works mainly by blocking central monoamine receptors, especially in the dopaminergic system.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: the usual starting dose of flupentixol is 1 mg as a single dose in the morning. If the response is not adequate after one week, the dose may be raised to 2 mg. Any daily dose above 2 mg should be given in divided doses, up to a maximum of 3 mg. Flupentixol has an activating effect, so it's advisable to give the last dose of the day no later than evening. Patients often respond within two or three days. If no effect has been seen after one week at the maximum dose, the medicine should be withdrawn. In psychosis, the usual starting dose is 3 to 9 mg twice daily, adjusted according to the response, with a maximum of 18 mg daily. Elderly: the usual starting dose is 0.5 mg as a single dose in the morning. After one week, if the response is inadequate, the dose may be increased to 1 mg once a day. Take care with any further increase, though some patients may need up to a maximum of 2 mg a day, which should be given in divided doses (1 mg at breakfast time and 1 mg at about evening time). Children: flupentixol is not recommended for children.
Side Effects
The main side effects of Flupentixol Dihydrochloride are extrapyramidal symptoms, which take several forms. Parkinsonian symptoms (including tremor) may occur more commonly in adults or the elderly, and they may appear gradually. Dystonia (abnormal face and body movements) and dyskinesia occur more commonly in children or young adults, and they appear after only a few doses. Akathisia (restlessness) characteristically occurs after large initial doses and may resemble an exacerbation of the condition being treated. Tardive dyskinesia (rhythmic, involuntary movements of tongue, face, and jaw) usually develops on long-term therapy or with high dosage, but it may develop on short-term treatment with low doses. Short-lived tardive dyskinesia may also occur after withdrawal of the drug. Other side effects include drowsiness, apathy, agitation, excitement and insomnia, convulsions, dizziness, headache, confusion, gastro-intestinal disturbances and nasal congestion. Antimuscarinic symptoms can occur too (such as dry mouth, constipation, difficulty with micturition, and blurred vision), and so can cardiovascular symptoms (such as hypotension, tachycardia, and arrhythmias). ECG changes have been seen, and cases of sudden death have occurred. Endocrine effects include menstrual disturbances, galactorrhoea, gynaecomastia, impotence, and weight gain. Blood dyscrasias (such as agranulocytosis and leucopenia) may develop, along with photosensitisation, contact sensitisation and rashes, and jaundice (including cholestatic). Corneal and lens opacities can occur, as can purplish pigmentation of the skin, cornea, conjunctiva, and retina.
Cautions & Contraindications
Warnings & Precautions
Flupentixol Dihydrochloride should be used with caution in patients with hepatic impairment, renal impairment, cardiovascular disease, Parkinson's disease (antipsychotics may make it worse), epilepsy (and conditions that make epilepsy more likely), depression, myasthenia gravis, prostatic hypertrophy, or a personal or family history of angle-closure glaucoma (avoid chlorpromazine, pericyazine and prochlorperazine in these conditions). Take care too in severe respiratory disease, and in patients with a history of jaundice or blood dyscrasias (do blood counts if an unexplained infection or fever develops). Antipsychotics should be used with caution in the elderly, who are particularly prone to postural hypotension and to hyper or hypothermia in very hot or cold weather. Doctors should think seriously before prescribing these medicines for elderly patients. Photosensitisation may occur with higher doses, so patients should avoid direct sunlight, and also in porphyria. Flupentixol Dihydrochloride should be used with caution in Parkinson's disease, severe arteriosclerosis, senile confusional state, or severe hepatic, renal, cardiovascular, cerebrovascular or respiratory disease.
Contraindications
Flupentixol may be contraindicated in people who are excitable and overactive, in comatose states, and where there is pre-existing CNS depression, bone marrow suppression or phaeochromocytoma. It is also unsuitable in severe alcohol, barbiturate and opiate intoxication. Flupentixol is not recommended for the treatment of severe depression that needs ECT and/or hospitalization. Most antipsychotics are best avoided during pregnancy unless they are essential, and it is advisable to stop breast feeding during treatment.
Drug Interactions
Common questions about Sentix 0.5 mg
What is Sentix 0.5 mg Tablet?
Sentix 0.5 mg Tablet is a medicine that contains Flupentixol Dihydrochloride. It is made by Eskayef Pharmaceuticals Ltd. It belongs to the SSRIs & related anti-depressant drugs group of medicines.
What is Sentix used for?
Sentix is used for: Depression, Anxiety, Schizophrenia, Bipolar Disorder.
What are the side effects of Sentix?
The main side effects of Flupentixol Dihydrochloride are extrapyramidal symptoms, which take several forms. Parkinsonian symptoms (including tremor) may occur more commonly in adults or the elderly, and they may appear gradually.
Can I take other medicines with Sentix?
Some medicines can interact with Flupentixol Dihydrochloride, for example: Metoclopramide. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Sentix is already among the lowest-priced brands of Flupentixol Dihydrochloride at this strength.
Do I need a prescription for Sentix?
Sentix is a prescription (Rx) medicine. Take it as your doctor advises.