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Other brands with the same active ingredient
These brands contain the same active ingredient (Semaglutide). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Sematid 7 is indicated for:
Pharmacology
Semaglutide is a GLP-1 analogue, and its sequence is 94% the same as human GLP-1. It works as a GLP-1 receptor agonist, which means it binds to the GLP-1 receptor and activates it, and it does this selectively.
Semaglutide lowers blood glucose only when glucose is high. It does this by stimulating insulin secretion and lowering glucagon secretion. A minor delay in gastric emptying is also part of how it brings blood glucose down. During hypoglycemia, semaglutide reduces insulin secretion and does not impair glucagon secretion.
It also reduces body weight and body fat mass, because it lowers appetite overall.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
take the tablet at least 30 minutes before the first food, beverage or other oral medicines of the day, with no more than 4 ounces (118 ml) of plain water only. The starter dose is 3 mg once daily for 30 days. After 30 days on the 3 mg dose, increase to the maintenance dose of 7 mg once daily. If additional glycemic control is needed after at least 30 days on the 7 mg dose, the dose can be increased to 14 mg once daily.
Dosage for other forms (3)
For Diabetes:
the starting dose is 0.25 mg once weekly. After 4 weeks, increase the dose to 0.5 mg once weekly. After at least 4 weeks on 0.5 mg once weekly, the dose can be increased to 1 mg once weekly to further improve glycemic control. Weekly doses higher than 1 mg are not recommended. Give the injection once weekly at any time of the day, with or without meals. Inject it subcutaneously in the abdomen, thigh or upper arm. You can change the injection site without adjusting the dose. Semaglutide should not be given intravenously or intramuscularly. If necessary, the day of weekly administration can be changed, as long as the time between two doses is at least 3 days (>72 hours). Once a new dosing day is chosen, continue with once weekly dosing.
patients treated with once weekly Semaglutide injection 0.5 mg can be moved to the 7 mg or 14 mg tablet. They can start the tablet up to 7 days after their last injection. There is no equivalent tablet dose for the 1 mg injection. Patients treated with the 14 mg tablet daily can be moved to the 0.5 mg subcutaneous injection once weekly, and they can start the injection the day after their last tablet.
For Obesity:
The starting dose is 0.25 mg Semaglutide once weekly for 4 weeks, given subcutaneously. If a patient doesn't tolerate a dose during dose escalation, consider delaying the escalation for 4 weeks. If the maintenance dose of 2.4 mg isn't tolerated, the dose can be lowered temporarily to 1.7 mg once weekly for a maximum of 4 weeks. After those 4 weeks, increase the dose to 2.4 mg again. Weekly doses higher than 2.4 mg are not recommended. Give the injection once weekly at any time of the day, with or without meals. Inject it subcutaneously in the abdomen, thigh or upper arm. The injection site can be changed without dose adjustment. Semaglutide should not be given intravenously or intramuscularly. If necessary, the day of weekly administration can be changed, as long as the time between two doses is at least 2 days (>48 hours). Once a new dosing day is chosen, continue with once weekly dosing.
Side Effects
Common side effects of Semaglutide include vomiting, stomach upset or indigestion, an inflamed stomach, reflux or heartburn or GERD, stomach pain and bloating of the stomach. You may also get constipation, a change in the way food or drink tastes, tiredness, less appetite and gas (flatulence). Another common effect is an increase of pancreatic enzymes (such as lipase and amylase). Serious allergic reactions (anaphylactic reactions) are rare. If you get symptoms such as breathing problems, swelling of the face and throat, wheezing, fast heartbeat, pale and cold skin, or feeling dizzy or weak, seek immediate medical help and inform your doctor straight away. Semaglutide should not be continued without that advice.
Cautions & Contraindications
Warnings & Precautions
Semaglutide should not be used in people with type 1 diabetes mellitus, and it should not be used to treat diabetic ketoacidosis. Patients need to be told to take care to avoid hypoglycemia when they drive or use machines. Semaglutide raises the heart rate. So doctors should be careful in patients who have heart conditions that a faster heart rate could make worse, such as tachyarrhythmias. When Semaglutide is given together with an insulin secretagogue (for example, sulfonylureas) or with insulin, the risk of hypoglycemia may be higher. Lowering the dose of the secretagogue or the insulin when Semaglutide is started may reduce this risk.
Contraindications
Semaglutide must not be given to anyone who is hypersensitive to semaglutide itself or to any ingredient in the formulation. That includes any non-medicinal ingredient and any component of the container. It must also not be used by people who have a personal or family history of Medullary Thyroid Carcinoma (MTC), or by people with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Semaglutide should not be used during pregnancy or breastfeeding.
Pregnancy & Breastfeeding
Pregnancy: Very few women were exposed to Semaglutide during pregnancy in clinical trials, and there are no adequate, well controlled studies in pregnant women. For this reason, Semaglutide should not be used during pregnancy. If a patient wants to become pregnant, or if pregnancy occurs, Semaglutide should be stopped. Because Semaglutide has a long half-life, it should be stopped at least 2 months before a planned pregnancy.
Lactation: There are no data on whether Semaglutide passes into human milk, what it does to a breastfed infant, or how it affects milk production. Semaglutide contains salcaprozate sodium (SNAC), an absorption enhancer, and it might build up in a breastfed infant. The potential for serious adverse reactions from this is unknown. There are also other formulations of Semaglutide that can be used during lactation. For these reasons, patients should be advised that breastfeeding is not recommended during treatment with Semaglutide. Women should also stop Semaglutide at least 2 months before a planned pregnancy, because the drug takes a long time to wash out of the body.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Semaglutide has not been studied well enough in children and adolescents below 18 years, so its safety and efficacy in this age group have not been established, and no data are available.
In elderly patients, no dose adjustment is needed because of age.
In renal impairment, no dose adjustment is needed for patients with mild, moderate or severe impairment. Semaglutide is not recommended for patients with end-stage renal disease.
In hepatic impairment, no dose adjustment is needed either. Even so, caution should be exercised when treating these patients with Semaglutide.
Overdose
Overdoses of Semaglutide of up to 4 mg in a single dose, and up to 4 mg in a week, have been reported in clinical trials. Nausea was the reaction reported most often. There is no specific antidote for Semaglutide overdose, so the patient should be given supportive treatment based on their clinical signs and symptoms.
When Semaglutide is added to metformin and/or thiazolidinedione therapy, the current dose of metformin and/or thiazolidinedione can stay unchanged. When it is added to a sulfonylurea or insulin, the doctor should consider lowering the dose of the sulfonylurea or insulin to reduce the risk of hypoglycemia. Checking blood glucose at home is not needed to adjust the dose of Semaglutide. It is needed, though, to adjust the dose of sulfonylurea and insulin, particularly when Semaglutide is started and the insulin is being reduced.
If a dose is missed, give it as soon as possible, within 5 days after the missed dose. If more than 5 days have passed, skip the missed dose and give the next one on the regular scheduled day. In both cases the patient can then go back to the usual once weekly schedule.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Injection: Keep semaglutide injection in a refrigerator at 2°C to 8°C. Don't freeze it, and keep it away from light. Keep all the medicine out of the reach of children.
Tablet: Store semaglutide tablets below 30°C in a cool, dry place and away from light. Keep all the medicine out of the reach of children.
Common questions about Sematid 7 7 mg
What is Sematid 7 7 mg Tablet?
Sematid 7 7 mg Tablet is a medicine that contains Semaglutide. It is made by The ACME Laboratories Ltd. It belongs to the GLP-1 receptor agonists group of medicines.
What is Sematid 7 used for?
Sematid 7 is used for: Hypertension, Hyperlipidemia, Type 2 Diabetes Mellitus, Diabetes Mellitus, Obesity.
What are the side effects of Sematid 7?
Common side effects of Semaglutide include vomiting, stomach upset or indigestion, an inflamed stomach, reflux or heartburn or GERD, stomach pain and bloating of the stomach. You may also get constipation, a change in the way food or drink tastes, tiredness, less appetite and gas (flatulence).
Can I take Sematid 7 during pregnancy or while breastfeeding?
Pregnancy: Very few women were exposed to Semaglutide during pregnancy in clinical trials, and there are no adequate, well controlled studies in pregnant women. For this reason, Semaglutide should not be used during pregnancy. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Sematid 7?
Overdoses of Semaglutide of up to 4 mg in a single dose, and up to 4 mg in a week, have been reported in clinical trials. Nausea was the reaction reported most often. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Sematid 7?
Injection: Keep semaglutide injection in a refrigerator at 2°C to 8°C. Don't freeze it, and keep it away from light.
Do I need a prescription for Sematid 7?
Sematid 7 is a prescription (Rx) medicine. Take it as your doctor advises.