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Same active ingredient — pay up to 29% less
These brands contain the same active ingredient (Bisoprolol Fumarate). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Selbis
Other strengths and forms by Beacon Pharmaceuticals PLC
Indications & Uses
Selbis is indicated for:
Pharmacology
Bisoprolol Fumarate is the most selective ß1 blocker. Of all the beta-blockers available up to now, it shows the highest affinity for the ß1 receptor. It selectively blocks the ß1 adrenergic receptor in the heart and vascular smooth muscle, which reduces heart rate and cardiac output and so lowers arterial hypertension. Lipid metabolism can be adversely affected by ß-blockers in patients with non-ß1 selective ß1-blocker, but Bisoprolol does not change the cholesterol fractions in long-term therapy, including the cardioprotective HDL-cholesterol.
The pharmacokinetic properties of Bisoprolol make a single daily dose possible and give an extremely low inter and intra-individual variability in plasma concentration profiles. Its high therapeutic reliability rests on these properties.
Absorption and bioavailability: Bisoprolol is almost completely (>90%) absorbed from the gastrointestinal tract. Because absorption is high and the first-pass effect is small (<10%), the absolute bioavailability is 88%. Taking food at the same time does not affect absorption.
Distribution: Bisoprolol is extensively distributed. The medium distribution volume is 3.51/kg.
Metabolism: Bisoprolol is metabolized through oxidative pathways, with no conjugation afterwards. All the metabolites are very polar, so they are eliminated by the kidneys. The major metabolites found in human plasma and urine had no pharmacological activity. In vitro data from studies in human liver microsomes show that Bisoprolol is mainly metabolized via CYPSA4 (-95%), and CYP2D6 has only a minor role.
Elimination: Clearance of Bisoprolol is balanced between renal elimination of the unchanged molecule (-50%) and hepatic metabolism (-50%) to metabolites, which are also excreted by the kidneys. Total clearance is approximately 15 I/h. The elimination half-life of Bisoprolol is 10 to 12 hours.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adult: When Bisoprolol fumarate is used for mild to moderate hypertension, the dose must be individualized to the needs of the patient. The usual starting dose is 5 mg once daily, either on its own or added to a diuretic. If 5 mg doesn't give an adequate response, the dose may be raised to 10 mg and then, if necessary, to 20 mg once daily. A suitable gap between dose changes is 2 weeks. Going above 20 mg once daily gives only a small extra benefit.
Children: Safety and effectiveness in children have not been established.
Patients with renal or hepatic impairment: In patients with hepatic impairment (hepatitis or cirrhosis) or renal dysfunction (creatinine clearance less than 40 mL/min), as in other patients, the initial daily dose should be 5 mg. Because the medicine may accumulate, take care when adjusting the dose upwards. Limited data suggest that bisoprolol fumarate is not dialysable, so drug replacement is not necessary in patients undergoing dialysis.
Geriatrics: In the elderly, the dose usually doesn't need to be adjusted, unless there is also significant renal or hepatic dysfunction.
Side Effects
Medicines can affect people in different ways, and the same is true of their side effects. The ones below are known to be associated with Bisoprolol Fumarate. A side effect appearing here doesn't mean everyone using the medicine will get it, or will get any side effect at all. The known side effects include fatigue, dizziness, headache, and disturbances of the gut such as nausea, vomiting, diarrhea, constipation or abdominal pain. Cold or numb extremities, for example the hands and feet, are also listed, along with muscle weakness or cramps. The other two are a slower than normal heart, and breathing difficulties due to a narrowing of the airways (bronchospasm) in people with asthma or COPD.
Cautions & Contraindications
Warnings & Precautions
Impaired renal or hepatic function Be careful when adjusting the dose of Bisoprolol Fumarate in patients with renal or hepatic impairment. Patients with a history of severe anaphylactic reaction to a variety of allergens may react more strongly to repeated exposure while they are taking beta-blockers, whether the exposure is accidental, diagnostic or therapeutic. These patients may also not respond to the usual doses of epinephrine used to treat allergic reactions.
Contraindications
Bisoprolol Fumarate should not be given to patients with cardiogenic shock, overt heart failure, second or third degree A-V block, right ventricular failure secondary to pulmonary hypertension, or sinus bradycardia.
Pregnancy & Breastfeeding
Pregnancy: In rats, bisoprolol fumarate did not cause birth defects (it was not teratogenic) at doses up to 150 mg/kg/day, which is 375 times the maximum recommended human daily dose. It was fetotoxic at 50 mg/kg/day, with an increase in late resorptions. At 150 mg/kg/day it was maternotoxic, meaning the mothers ate less and gained less body weight. In rabbits, bisoprolol fumarate was not teratogenic at doses up to 12.5 mg/kg/day, which is 31 times the maximum recommended human daily dose, but at 12.5 mg/kg/day it was embryolethal, with an increase in early resorptions. There are no studies in pregnant women. So bisoprolol fumarate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Lactation: Small amounts of bisoprolol fumarate (<2% of the dose) have been found in the milk of lactating rats. It is not known whether the medicine passes into human milk. If bisoprolol fumarate is considered essential, mothers should stop nursing.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Bisoprolol Fumarate in a dry place, away from light and heat. Keep it where children can't reach it.
Drug Interactions
Common questions about Selbis 2.5 mg
What is Selbis 2.5 mg Tablet?
Selbis 2.5 mg Tablet is a medicine that contains Bisoprolol Fumarate. It is made by Beacon Pharmaceuticals PLC. It belongs to the Anti adrenergic agent (Beta blockers) group of medicines.
What is Selbis used for?
Selbis is used for: Hypertension, Angina Pectoris, Heart Failure.
What are the side effects of Selbis?
Medicines can affect people in different ways, and the same is true of their side effects. The ones below are known to be associated with Bisoprolol Fumarate.
Can I take Selbis during pregnancy or while breastfeeding?
Pregnancy: In rats, bisoprolol fumarate did not cause birth defects (it was not teratogenic) at doses up to 150 mg/kg/day, which is 375 times the maximum recommended human daily dose. It was fetotoxic at 50 mg/kg/day, with an increase in late resorptions. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Selbis?
Store Bisoprolol Fumarate in a dry place, away from light and heat. Keep it where children can't reach it.
Can I take other medicines with Selbis?
Some medicines can interact with Bisoprolol Fumarate, for example: Disopyramide, Bisoprolol Fumarate + Hydrochlorothiazide, Clonidine Hydrochloride, Verapamil Hydrochloride, Diltiazem Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Bisopol by Euro Pharma Ltd. has the same ingredient and strength for ৳5.00 per unit, compared with ৳7.00 for Selbis. Ask your doctor or pharmacist before switching.
Do I need a prescription for Selbis?
Selbis is a prescription (Rx) medicine. Take it as your doctor advises.