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Indications & Uses
Sandostatin is indicated for:
Pharmacology
Octreotide Acetate Injection acts much like somatostatin, the natural hormone. It blocks GH, glucagon and insulin even more strongly than somatostatin does. Like somatostatin, it also suppresses the luteinizing hormone (LH) response to gonadotropin releasing hormone (GnRH), reduces splanchnic blood flow, and stops the release of serotonin, gastrin, VIP, secretin, motilin and pancreatic polypeptide.
Because of these actions, octreotide has been used to treat the symptoms of metastatic carcinoid tumors (flushing and diarrhea) and of VIP secreting adenomas (watery diarrhea). It substantially lowers GH and/or IGF-1 (somatomedin C) levels in patients with acromegaly. Single doses of octreotide have been shown to reduce gallbladder contractility and decrease bile secretion in normal volunteers. Controlled clinical trials found that gallstones or biliary sludge formed markedly more often.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Octreotide Acetate Injection can be given under the skin (subcutaneously) or into a vein (intravenously).
Acromegaly: the recommended starting dose of Octreotide acetate is 50 mcg three times daily for the first 2 weeks of treatment. The maintenance dose is 100 mcg to 500 mcg three times daily.
Carcinoid tumors: the recommended range is 100 mcg to 600 mcg daily, split into two to four doses, during the first 2 weeks of treatment.
VIPomas: the recommended range is 200 mcg to 300 mcg daily, split into two to four doses, during the first 2 weeks of treatment.
Pediatric use: safety and efficacy of Octreotide Acetate Injection in children have not been demonstrated.
Side Effects
In people with acromegaly, the most common side effects of octreotide acetate (reported in more than 10% of patients) are gallbladder abnormalities, sinus bradycardia, diarrhea, loose stools, nausea, abdominal discomfort, hyperglycemia and hypothyroidism. In patients treated for other conditions, the most common side effect, also in more than 10%, is gallbladder abnormalities.
Cautions & Contraindications
Warnings & Precautions
Cardiac Function Abnormalities Octreotide Acetate Injection can raise the risk of higher degree atrioventricular blocks. If it is given intravenously, think about cardiac monitoring. Bradycardia, arrhythmias or conduction abnormalities may occur, so use it with caution in patients who are at risk. The dose of cardiac medicines may need to be adjusted. Cholelithiasis and Complications of Cholelithiasis Monitor the patient periodically. If complications of cholelithiasis are suspected, stop the medicine. Glucose Metabolism Hypoglycemia or hyperglycemia may occur. Glucose monitoring is recommended, and anti-diabetic treatment may need adjustment. Thyroid Function Hypothyroidism may occur, so monitor thyroid levels periodically. Steatorrhea and Malabsorption of Dietary Fats New onset steatorrhea, stool discoloration, loose stools, abdominal bloating and weight loss may occur. If a patient reports these symptoms as new or getting worse, evaluate for possible pancreatic exocrine insufficiency.
Pregnancy & Breastfeeding
There are only limited data on Octreotide Acetate Injection in pregnant women, and they aren't enough to show whether the medicine carries a risk of major birth defects or miscarriage. In animal studies, octreotide was given by IV to pregnant rats and rabbits during organogenesis, at doses 7 times (rats) and 13 times (rabbits) the maximum recommended human dose (MRHD) of 1.5 mg/day, based on body surface area (BSA). No adverse developmental effects were seen. In a pre- and post-natal study in rats, IV doses of octreotide below the MRHD based on BSA caused transient growth retardation in the offspring, but postnatal development was not affected.
Nothing is known about whether Octreotide Acetate Injection passes into human milk, what it does to a breastfed infant, or how it affects milk production. Studies show that octreotide given subcutaneously passes into the milk of lactating rats. Lactation physiology differs between species, though, so animal data may not reliably predict drug levels in human milk. The developmental and health benefits of breastfeeding should be weighed together with the mother's clinical need for the medicine, and with any possible adverse effects on the breastfed child, whether from the injection or from the mother's underlying condition.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Octreotide Acetate at 2-8° C. It stays stable at room temperature for up to 14 days.
Drug Interactions
Common questions about Sandostatin 50 mcg/ml
What is Sandostatin 50 mcg/ml Injection?
Sandostatin 50 mcg/ml Injection is a medicine that contains Octreotide Acetate. It is made by Nevian Lifescience PLC. It belongs to the Growth hormone antagonist group of medicines.
What is Sandostatin used for?
Sandostatin is used for: Diarrhea.
What are the side effects of Sandostatin?
In people with acromegaly, the most common side effects of octreotide acetate (reported in more than 10% of patients) are gallbladder abnormalities, sinus bradycardia, diarrhea, loose stools, nausea, abdominal discomfort, hyperglycemia and hypothyroidism. In patients treated for other conditions, the most common side effect, also in more than 10%, is gallbladder abnormalities.
Can I take Sandostatin during pregnancy or while breastfeeding?
There are only limited data on Octreotide Acetate Injection in pregnant women, and they aren't enough to show whether the medicine carries a risk of major birth defects or miscarriage. In animal studies, octreotide was given by IV to pregnant rats and rabbits during organogenesis, at doses 7 times (rats) and 13 times (rabbits) the maximum recommended human dose (MRHD) of 1.5 mg/day, based on body surface area (BSA). Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Sandostatin?
Keep Octreotide Acetate at 2-8° C. It stays stable at room temperature for up to 14 days.
Can I take other medicines with Sandostatin?
Some medicines can interact with Octreotide Acetate, for example: Cyclosporine, Bromocriptine, Terfenadine, Regular Insulin Human + Isophane Insulin Human, Insulin Human [rDNA], Insulin (Human) 30/70. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Sandostatin?
Sandostatin is a prescription (Rx) medicine. Take it as your doctor advises.