Pricing
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All price changes →Indications & Uses
Rovanox is indicated for:
Pharmacology
Ropivacaine is an amino amide local anesthetic, and it is supplied as the pure S-(-)-enantiomer. Local anesthetics block the generation and the conduction of nerve impulses. They presumably do this by raising the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, how anesthesia progresses depends on the diameter, myelination and conduction velocity of the nerve fibers affected. Clinically, nerve function is lost in this order: (1) pain, (2) temperature, (3) touch, (4) proprioception, and (5) skeletal muscle tone.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Important administration instructions: there have been reports of chondrolysis in patients who received intra-articular infusions of local anesthetics after arthroscopic and other surgical procedures. Ropivacaine is not approved for this use. Rapid injection of a large volume of local anesthetic solution should be avoided, and fractional (incremental) doses should always be used. Give the smallest dose and concentration that produces the result you want. The dose of any local anesthetic depends on the anesthetic procedure, the area to be anesthetized, the vascularity of the tissues, the number of neuronal segments to be blocked, the depth of anesthesia and degree of muscle relaxation required, the duration of anesthesia desired, individual tolerance, and the physical condition of the patient. Patients in poor general condition because of aging or other compromising factors, such as partial or complete heart conduction block, advanced liver disease or severe renal dysfunction, need special attention, although regional anesthesia is frequently indicated in these patients. To reduce the risk of potentially serious adverse reactions, try to bring the patient's condition to the best possible state before major blocks are done, and adjust the dose to match. Give an adequate test dose (3 to 5 mL of a short acting local anesthetic solution containing epinephrine) before induction of complete block. Repeat this test dose if the patient is moved in a way that may have displaced the epidural catheter. Allow adequate time for anesthesia to begin after each test dose. These products are for single dose use and are free from preservatives, so any solution left in an opened container should be thrown away promptly.
Dosage recommendations: please see the attachment (Innovator Product Monograph) for the detailed dosage guideline.
Side Effects
The most common side effects of Ropivacaine Hydrochloride, each seen in 5% or more of people, are low blood pressure (hypotension), nausea, vomiting, slow heart rate (bradycardia), fever, pain, postoperative complications, anemia, paresthesia, headache, pruritus and back pain.
Cautions & Contraindications
Warnings & Precautions
If dose-related toxicity, underventilation or altered sensitivity isn't managed promptly, acidosis can develop, and so can cardiac arrest and, possibly, death. When Ropivacaine Hydrochloride blocks are performed, the injection can go into a vein by mistake. This may cause cardiac arrhythmia or cardiac arrest. Local anesthetics given as an infusion into a joint (intra-articular) may cause chondrolysis. Ropivacaine Hydrochloride is not approved for this use. Signs of methemoglobinemia may also occur.
Contraindications
Ropivacaine Hydrochloride Injection, USP must not be given to anyone who is known to be hypersensitive to ropivacaine, or to any other local anesthetic of the amide type.
Pregnancy & Breastfeeding
There's no human data on ropivacaine injection in pregnant women, so we can't judge whether it carries a risk of major birth defects, miscarriage, or other harmful outcomes for the mother or the baby.
One published report found that ropivacaine passes into breast milk at low levels in women who were given it during cesarean section. No adverse reactions were reported in the infants. Nothing is known about its effect on milk production.
When deciding on use during breastfeeding, the benefits of breastfeeding for the baby's development and health should be weighed together with the mother's clinical need for ropivacaine. The possible adverse effects on the breastfed child, either from ropivacaine or from the mother's underlying condition, should be considered as well.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric Use
The safety and efficacy of ropivacaine in pediatric patients have not been established.
Geriatric Use
In 71 controlled and uncontrolled clinical studies, 2,978 subjects were given ropivacaine injection. Of these, 803 patients (27%) were 65 years of age or older, and 127 patients (4%) were 75 years of age and over. Ropivacaine Hydrochloride injection was found to be safe and effective in the patients in these studies. One published article reports that various pharmacodynamic measures differed with increasing age. In one study, the upper level of analgesia rose with age, the maximum decrease of mean arterial pressure (MAP) in the first hour after epidural administration became smaller with age, and the intensity of motor blockade increased with age.
Hepatic Impairment
Ropivacaine is an amide-type local anesthetic, and these medicines are metabolized by the liver. So they should be used cautiously in patients with hepatic disease, especially when doses are repeated. Patients with severe hepatic disease can't metabolize local anesthetics normally, which puts them at greater risk of toxic plasma concentrations.
Renal Impairment
Ropivacaine Hydrochloride and its metabolites are known to be excreted by the kidney, and the risk of toxic reactions may be greater in patients with impaired renal function. For this reason, take care in choosing the dose and start at the low end of the dosage range. It may also be useful to monitor renal function.
Common questions about Rovanox 100 mg/20 ml
What is Rovanox 100 mg/20 ml IV Infusion?
Rovanox 100 mg/20 ml IV Infusion is a medicine that contains Ropivacaine Hydrochloride. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Local & Surface anesthesia group of medicines.
What is Rovanox used for?
Rovanox is used for: Pain.
What are the side effects of Rovanox?
The most common side effects of Ropivacaine Hydrochloride, each seen in 5% or more of people, are low blood pressure (hypotension), nausea, vomiting, slow heart rate (bradycardia), fever, pain, postoperative complications, anemia, paresthesia, headache, pruritus and back pain.
Can I take Rovanox during pregnancy or while breastfeeding?
There's no human data on ropivacaine injection in pregnant women, so we can't judge whether it carries a risk of major birth defects, miscarriage, or other harmful outcomes for the mother or the baby. One published report found that ropivacaine passes into breast milk at low levels in women who were given it during cesarean section. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Is there a cheaper medicine with the same ingredient?
Rovanox is already among the lowest-priced brands of Ropivacaine Hydrochloride at this strength.
Do I need a prescription for Rovanox?
Rovanox is a prescription (Rx) medicine. Take it as your doctor advises.