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Same active ingredient — pay up to 26% less
These brands contain the same active ingredient (Ribociclib). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Ribolib is indicated for:
Pharmacology
Ribociclib blocks two enzymes called cyclin-dependent kinase (CDK) 4 and 6. These kinases switch on when they bind to D-cyclins, and they send signals that push a cell through the cell cycle so it can multiply. The cyclin D-CDK4/6 complex controls this progress by phosphorylating the retinoblastoma protein (pRb).
In laboratory (in vitro) tests on breast cancer cell lines, ribociclib reduced pRb phosphorylation. This stopped the cells in the G1 phase of the cell cycle and cut down cell proliferation. In vivo, ribociclib given alone to rats carrying human tumour cells (a xenograft model) led to smaller tumour volumes, and this matched the drop in pRb phosphorylation.
Studies in patient-derived estrogen receptor positive breast cancer xenograft models also looked at combinations. Ribociclib together with an antiestrogen (for example letrozole) slowed tumour growth more than either drug did alone. The combination of ribociclib and fulvestrant also slowed tumour growth in an estrogen receptor positive breast cancer xenograft model.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual dose of Ribociclib for adults is 600 mg by mouth once a day for 21 days in a row. After that you stop for 7 days, which makes one full cycle of 28 days. You can take Ribociclib with food or without it.
Side Effects
The most common side effects of ribociclib, seen in more than 20% of people, are neutropenia, nausea, infections, fatigue, diarrhea, leukopenia, vomiting, alopecia, headache, constipation, rash and cough.
Cautions & Contraindications
Warnings & Precautions
Interstitial lung disease/pneumonitis Interstitial lung disease (ILD) and/or pneumonitis can be severe, life-threatening or fatal in patients treated with Ribociclib and other CDK4/6 inhibitors. Watch patients for lung symptoms that may point to ILD pneumonitis, such as hypoxia, cough and dyspnea. Severe cutaneous adverse reactions Severe cutaneous adverse reactions (SCARs) can occur. These include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS). QT interval prolongation Ribociclib has been shown to prolong the QT interval. Depending on the QT prolongation seen during treatment, the dose may need to be interrupted, reduced or stopped. Check serum electrolytes (including potassium, calcium, phosphorous and magnesium) before treatment starts, at the beginning of the first 6 cycles, and as clinically indicated. Increased QT prolongation with concomitant use of tamoxifen Ribociclib is not indicated for use together with tamoxifen. Hepatobiliary toxicity Do liver function tests (LFTs) before starting Ribociclib. Then repeat them every 2 weeks for the first 2 cycles, at the beginning of each of the next 4 cycles, and as clinically indicated. Depending on how severe the transaminase elevations are, the dose may need to be interrupted, reduced or stopped. Neutropenia Do a complete blood count (CBC) before starting Ribociclib. Repeat it every 2 weeks for the first 2 cycles, at the beginning of each of the next 4 cycles, and as clinically indicated. Depending on how severe the neutropenia is, the dose may need to be interrupted, reduced or stopped. Embryo-fetal toxicity Animal studies and the way the medicine works show that Ribociclib can harm the fetus when given to a pregnant woman. Women who could become pregnant should be advised to use effective contraception during treatment and for at least 3 weeks after the last dose.
Contraindications
Ribociclib must not be given to anyone who is known to be allergic to it or to any of the other ingredients in the product.
Pregnancy & Breastfeeding
Animal studies and the way ribociclib works suggest that it can harm the baby if a pregnant woman takes it. Females of reproductive potential should have a pregnancy test before starting treatment with ribociclib.
It isn't known whether ribociclib passes into human milk. There are also no data on how it affects a breastfed infant or milk production.
Ribociclib may impair fertility in males of reproductive potential.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: The safety and efficacy of Ribociclib in pediatric patients have not been established.
Geriatric use: Doctors saw no overall difference in the safety or effectiveness of Ribociclib between geriatric patients and younger patients.
Hepatic impairment: Patients with mild hepatic impairment (Child-Pugh A) need no dose adjustment. For moderate (Child-Pugh B) and severe hepatic impairment (Child-Pugh C), a reduced starting dose of 400 mg is recommended.
Renal impairment: Patients with mild or moderate renal impairment need no dose adjustment. In severe renal impairment, a starting dose of 200 mg is recommended. Ribociclib has not been studied in breast cancer patients with severe renal impairment.
Storage
Store Ribociclib below 30°C, away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Ribolib 200 mg
What is Ribolib 200 mg Tablet?
Ribolib 200 mg Tablet is a medicine that contains Ribociclib. It is made by Beacon Pharmaceuticals PLC. It belongs to the Targeted Cancer Therapy group of medicines.
What is Ribolib used for?
Ribolib is used for: Cancer.
What are the side effects of Ribolib?
The most common side effects of ribociclib, seen in more than 20% of people, are neutropenia, nausea, infections, fatigue, diarrhea, leukopenia, vomiting, alopecia, headache, constipation, rash and cough.
Can I take Ribolib during pregnancy or while breastfeeding?
Animal studies and the way ribociclib works suggest that it can harm the baby if a pregnant woman takes it. Females of reproductive potential should have a pregnancy test before starting treatment with ribociclib. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Ribolib?
Store Ribociclib below 30°C, away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Ribolib?
Some medicines can interact with Ribociclib, for example: Ritonavir, Rifampicin. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Riboxen by Everest Pharmaceuticals Ltd. has the same ingredient and strength for ৳700.00 per unit, compared with ৳952.00 for Ribolib. Ask your doctor or pharmacist before switching.
Do I need a prescription for Ribolib?
Ribolib is a prescription (Rx) medicine. Take it as your doctor advises.