Save on this medicine
Other brands with the same active ingredient
These brands contain the same active ingredient (Adefovir Dipivoxil). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Virodip is used to treat chronic hepatitis B in adults who have active viral replication, along with either persistently raised liver enzymes (ALT or AST) or evidence of active liver disease on biopsy.
Pharmacology
Adefovir dipivoxil is a diester prodrug of adefovir, an acyclic nucleotide analog that acts against the hepatitis B virus (HBV). Once inside the body, cellular kinases convert adefovir into its active form, adefovir diphosphate. This active metabolite blocks HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate, and once incorporated into the viral DNA strand, it halts further chain formation.
Following a single 10 mg oral dose, adefovir shows an approximate bioavailability of 59%. It binds only minimally to human plasma or serum proteins, at about 4% in vitro. The drug is cleared from the body through the kidneys, via a combination of glomerular filtration and active tubular secretion.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended dose for adults with chronic hepatitis B and adequate kidney function is one 10 mg tablet of Adefovir, taken by mouth once a day. It can be taken with or without food.
Side Effects
The most common side effects of Adefovir Dipivoxil are weakness, headache, stomach pain and nausea. Severe acute exacerbations of hepatitis have been reported in patients who stopped anti-hepatitis B therapy, and this includes therapy with Adefovir Dipivoxil. In patients who are at risk of kidney problems, or who already have underlying renal dysfunction, long-term use may result in nephrotoxicity. Lactic acidosis and severe hepatomegaly with steatosis have been reported with nucleoside analogs, whether used alone or together with other antiretrovirals. Some of these cases were fatal.
Cautions & Contraindications
Warnings & Precautions
Patients who stop taking Virodip should continue to have their liver function checked periodically for some time afterward. Those with existing kidney problems, or at risk of developing them, need close monitoring of kidney function and may need their dose adjusted accordingly.
Contraindications
Adefovir dipivoxil should not be used by patients who are known to be hypersensitive to it or to any other ingredient in the formulation.
Pregnancy & Breastfeeding
Pregnancy Category C. No adequate, well-controlled studies have looked at adefovir dipivoxil use in pregnant women. It should be used during pregnancy only if clearly needed, after weighing the potential risks against the benefits. Whether adefovir passes into human breast milk isn't known, so mothers taking adefovir dipivoxil should be advised not to breast-feed.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Adefovir Dipivoxil at 500 mg daily for 2 weeks, and at 250 mg daily for 12 weeks, has been linked with gastrointestinal side effects. If an overdose happens, the patient should be watched for any signs of toxicity, and standard supportive treatment should be given as needed.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Adefovir Dipivoxil in a cool, dry place, away from light and moisture. And keep all medicines out of the reach of children.
Drug Interactions
Common questions about Rezoven 10 mg
What is Rezoven 10 mg Tablet?
Rezoven 10 mg Tablet is a medicine that contains Adefovir Dipivoxil. It is made by Beximco Pharmaceuticals Ltd. It belongs to the Hepatic viral infections (Hepatitis B) group of medicines.
What is Rezoven used for?
Virodip is used to treat chronic hepatitis B in adults who have active viral replication, along with either persistently raised liver enzymes (ALT or AST) or evidence of active liver disease on biopsy.
What are the side effects of Rezoven?
The most common side effects of Adefovir Dipivoxil are weakness, headache, stomach pain and nausea. Severe acute exacerbations of hepatitis have been reported in patients who stopped anti-hepatitis B therapy, and this includes therapy with Adefovir Dipivoxil.
Can I take Rezoven during pregnancy or while breastfeeding?
Pregnancy Category C. No adequate, well-controlled studies have looked at adefovir dipivoxil use in pregnant women. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Rezoven?
Adefovir Dipivoxil at 500 mg daily for 2 weeks, and at 250 mg daily for 12 weeks, has been linked with gastrointestinal side effects. If an overdose happens, the patient should be watched for any signs of toxicity, and standard supportive treatment should be given as needed. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Rezoven?
Keep Adefovir Dipivoxil in a cool, dry place, away from light and moisture. And keep all medicines out of the reach of children.
Can I take other medicines with Rezoven?
Some medicines can interact with Adefovir Dipivoxil, for example: Ibuprofen, Trimethoprim, Lamivudine, Paracetamol, Entecavir Monohydrate. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Rezoven?
Rezoven is a prescription (Rx) medicine. Take it as your doctor advises.