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Revocon 12.5

Rx

12.5 mg • Tablet

Tetrabenazine • Sun Pharmaceuticals (EZ) Ltd., Narayanganj

Therapeutic class: Atypical neuroleptic drugs

🌐 বাংলায় দেখুন

Available as: 12.5 mg

Indications & Uses

Benazin is indicated for the treatment of chorea associated with Huntington's disease.

Pharmacology

Tetrabenazine was originally developed as an antipsychotic, but today it is mainly used to relieve symptoms of various hyperkinetic movement disorders. It works as a vesicular monoamine transporter-2 (VMAT-2) inhibitor and is used specifically to treat chorea associated with Huntington's disease.

Dosage Reference

Reference Information Only

Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.

Adults:

You can take Tetrabenazine with or without food. The dose has to be set for each patient, with careful weekly titration.

In the 1st week the starting dose is 12.5 mg daily. In the 2nd week it goes up to 25 mg, given as 12.5 mg twice daily. After that, increase slowly at weekly intervals by 12.5 mg, until you reach a dose the patient tolerates that reduces chorea. Doses of 37.5 mg and up to 50 mg per day should be given in three divided doses, and no single dose should be more than 25 mg.

Patients who need more than 50 mg per day should be genotyped for the drug-metabolizing enzyme CYP2D6, to find out whether they are poor metabolizers or extensive metabolizers. In poor metabolizers the maximum daily dose is 50 mg, with a maximum single dose of 25 mg. In extensive and intermediate metabolizers the maximum daily dose is 100 mg, with a maximum single dose of 37.5 mg.

If serious adverse reactions occur, stop the titration and lower the dose. If the adverse reactions don't resolve, consider withdrawing Tetrabenazine.

Pediatric and geriatric use: safety and effectiveness in pediatric patients have not been established. The pharmacokinetics of Tetrabenazine and its primary metabolites have not been formally studied in geriatric subjects.

Side Effects

Common side effects: the most frequently reported reactions (occurring in more than 10% of patients and at least 5% more often than with placebo) were sedation or drowsiness, fatigue, insomnia, depression, akathisia (restlessness), anxiety or worsening of existing anxiety, and nausea. Rare side effects: suicidal thoughts; neuroleptic malignant syndrome, a reaction marked by fever, muscle stiffness and confusion; and pneumonia.

Cautions & Contraindications

Warnings & Precautions

The benefit of treatment and the potential for adverse effects, such as worsening mood, cognition, rigidity, and functional capacity, should be periodically re-evaluated. When given together with a strong CYP2D6 inhibitor (e.g., fluoxetine, paroxetine), the maximum daily dose should not exceed 50 mg/day and the maximum single dose should not exceed 25 mg. If Neuroleptic Malignant Syndrome occurs, treatment should be discontinued. The dose should be reduced or treatment discontinued if the patient experiences restlessness, agitation, akathisia, or parkinsonism. Treatment may impair the patient's ability to drive or operate complex machinery. Tetrabenzine is not recommended in combination with other drugs that prolong the QTc interval.

Contraindications

Tetrabenazine must not be used in people who are actively suicidal or who have depression that is untreated or not adequately treated, in people with hepatic impairment, in those currently taking monoamine oxidase inhibitors (MAOIs) or reserpine, or in those currently taking deutetrabenazine or valbenazine.

Pregnancy & Breastfeeding

Pregnancy: There isn't enough evidence to know whether Tetrabenazine poses a developmental risk if taken during pregnancy.

Breastfeeding: It isn't known whether Tetrabenazine or its breakdown products pass into breast milk.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Overdose

If someone takes too much Tetrabenazine, they may become drowsy, start sweating and develop hypothermia.

⚠️ In an emergency call 999 or go to the nearest hospital emergency department.

Storage

Keep Tetrabenazine in a cool, dry place and protect it from light and moisture. Keep all medicines out of the reach of children.

Drug Interactions

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Moderate Paroxetine

Moderate Fluoxetine

Common questions about Revocon 12.5 12.5 mg

What is Revocon 12.5 12.5 mg Tablet?

Revocon 12.5 12.5 mg Tablet is a medicine that contains Tetrabenazine. It is made by Sun Pharmaceuticals (EZ) Ltd., Narayanganj. It belongs to the Atypical neuroleptic drugs group of medicines.

What is Revocon 12.5 used for?

Benazin is indicated for the treatment of chorea associated with Huntington's disease.

What are the side effects of Revocon 12.5?

Common side effects: the most frequently reported reactions (occurring in more than 10% of patients and at least 5% more often than with placebo) were sedation or drowsiness, fatigue, insomnia, depression, akathisia (restlessness), anxiety or worsening of existing anxiety, and nausea. Rare side effects: suicidal thoughts; neuroleptic malignant syndrome, a reaction marked by fever, muscle stiffness and confusion; and pneumonia.

Can I take Revocon 12.5 during pregnancy or while breastfeeding?

Pregnancy: There isn't enough evidence to know whether Tetrabenazine poses a developmental risk if taken during pregnancy. Breastfeeding: It isn't known whether Tetrabenazine or its breakdown products pass into breast milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

What happens if I take too much Revocon 12.5?

If someone takes too much Tetrabenazine, they may become drowsy, start sweating and develop hypothermia. In an emergency call 999 or go to the nearest hospital emergency department.

How should I store Revocon 12.5?