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Indications & Uses
Reptylin is indicated for:
Pharmacology
The exact mechanism by which this drug works is not fully understood. Amitriptyline is thought to block the pump-like mechanism in nerve cell membranes that normally reabsorbs transmitter amines such as norepinephrine and serotonin, thereby raising their levels at the brain's synaptic clefts. These amines play an important role in regulating mood. According to the monoamine hypothesis of depression, one of the oldest theories in this field, depressive symptoms arise when the brain has insufficient transmission of serotonin (5-HT) and/or norepinephrine (NE). By counteracting this shortfall, amitriptyline may achieve its effect of easing depressive symptoms. It remains unclear whether its pain-relieving effects stem from this same mood-related activity, from a separate and less well understood pharmacological action, or from a combination of both.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Depression: The usual starting dose is 75 mg daily (30 to 75 mg daily for elderly patients and adolescents), taken either in divided doses or as a single dose at bedtime. The dose may be increased gradually as needed to 150 to 200 mg daily. Amitriptyline is not recommended for depression in children under 16 years of age.
Nocturnal enuresis (bedwetting): Children aged 7 to 10 years: 10 to 20 mg at night. Children aged 11 to 16 years: 25 to 50 mg at night. Treatment, including gradual withdrawal, should not continue for more than 3 months. A full physical examination is required before any further course of treatment.
Prevention of migraine: 100 mg daily.
Tension headache: 10 to 25 mg three times daily.
Side Effects
Anticholinergic: excessive sweating, dry mouth, blurred vision, very high body temperature, difficulty passing urine and widening of the urinary tract. Cardiovascular reactions: low blood pressure, fainting, postural hypotension, high blood pressure, fast heartbeat, palpitations, myocardial infarction, etc. CNS and neuromuscular: confusional states, poor concentration, disorientation, delusions, etc. Allergic: skin rash, urticaria, photosensitisation, etc. Haematological: bone-marrow depression. Gastrointestinal: nausea, epigastric distress, vomiting, loss of appetite, stomatitis, unpleasant taste, weight loss, diarrhoea, constipation, etc. Endocrine: testicular swelling, gynaecomastia, breast enlargement, galactorrhoea, etc.
Cautions & Contraindications
Warnings & Precautions
Use with caution in patients with a history of epilepsy, glaucoma or raised intra-ocular pressure, urinary retention, heart disease, diabetes, liver impairment, thyroid disease, or psychoses (it may worsen mania), and during pregnancy.
Contraindications
Amitriptyline should not be used in people who have had a myocardial infarction (heart attack), in those with arrhythmias (particularly heart block of any degree), in mania, or in severe liver disease. During the early stages of treatment, sedation may affect the ability to drive or operate machinery.
Pregnancy & Breastfeeding
Pregnancy Category C. Studies show amitriptyline crosses the placenta, so it should be used in pregnancy only if the potential benefit to the mother outweighs the potential risk to the unborn baby. The drug also passes into breast milk, and nursing infants may be at risk of serious side effects as a result. Because of this, a decision needs to be made about whether to stop breastfeeding or stop the medicine, weighing how important it is for the mother's treatment.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Amitriptyline Hydrochloride in a cool, dry place, below 30°C. Protect it from light and moisture.
Drug Interactions
Common questions about Reptylin 25 mg
What is Reptylin 25 mg Tablet?
Reptylin 25 mg Tablet is a medicine that contains Amitriptyline Hydrochloride. It is made by Albion Laboratories Ltd. It belongs to the Tricyclic Anti-depressant group of medicines.
What is Reptylin used for?
Reptylin is used for: Migraine, Headache, Pain, Depression.
What are the side effects of Reptylin?
Anticholinergic: excessive sweating, dry mouth, blurred vision, very high body temperature, difficulty passing urine and widening of the urinary tract. Cardiovascular reactions: low blood pressure, fainting, postural hypotension, high blood pressure, fast heartbeat, palpitations, myocardial infarction, etc.
Can I take Reptylin during pregnancy or while breastfeeding?
Pregnancy Category C. Studies show amitriptyline crosses the placenta, so it should be used in pregnancy only if the potential benefit to the mother outweighs the potential risk to the unborn baby. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Reptylin?
Keep Amitriptyline Hydrochloride in a cool, dry place, below 30°C. Protect it from light and moisture.
Can I take other medicines with Reptylin?
Some medicines can interact with Amitriptyline Hydrochloride, for example: Moxifloxacin, Cimetidine, Terfenadine, Dextromethorphan + Phenylephrine + Triprolidine, Tamsulosin Hydrochloride + Dutasteride, Tamsulosin Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Reptylin is already among the lowest-priced brands of Amitriptyline Hydrochloride at this strength.
Do I need a prescription for Reptylin?
Reptylin is a prescription (Rx) medicine. Take it as your doctor advises.