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Indications & Uses
Fluorometholone + Tetrahydrozoline eye drop is used for acute and chronic allergic non-infectious conjunctivitis and keratitis with severe swelling and intravascular injection. It is also used for non-infectious inflammation of the anterior segment of the eye, including anterior uveitis, episcleritis and scleritis. The third use is for post-operative irritative conditions after strabismus; cataract and glaucoma surgery, with supplementary antimicrobial therapy.
Pharmacology
Fluorometholone is thought to work by inducing proteins that inhibit phospholipase A2. These proteins control the making of strong inflammation mediators such as prostaglandins and leukotrienes, and they do this by blocking the release of arachidonic acid, the precursor both share. Tetrahydrozoline works in a different way. It is an alpha agonist that narrows the blood vessels of the conjunctiva, and this relieves the redness of the eye.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: put 1 drop into the conjunctival sac 2 to 3 times a day. In severe cases the dose may be raised to 1 drop every hour for the first one to two days.
Children: safety and effectiveness in children below 2 years of age have not been established.
Side Effects
Fluorometholone with tetrahydrozoline can cause a mild burning sensation, a reversible rise in intraocular pressure and reactive hyperemia. Cataract, corneal defects and glaucoma may occur, and with chronic use there can be systemic effects.
Cautions & Contraindications
Warnings & Precautions
Avoid using Fluorometholone + Tetrahydrozoline for long periods. Doctors should weigh the risks against the benefits before prescribing it to patients with severe blood circulation diseases or metabolic disturbances. The same care applies to patients who are being treated with MAOIs or other drugs that may raise blood pressure, and to those with a history of cataract, herpes simplex infection or rhinitis sicca.
Contraindications
Fluorometholone with tetrahydrozoline should not be used in infectious conjunctivitis or keratitis, or when the cornea has been injured or has ulcers. It is also contraindicated in glaucoma, in diseases that involve stromal damage of the cornea or sclera, and in dry eyes.
Pregnancy & Breastfeeding
There are no adequate and well-controlled studies of Fluorometholone and Tetrahydrozoline in pregnancy or during breast-feeding. So this combination should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
When this product is used as directed, an overdose is very unlikely. There is no information on overdosage with fluorometholone, and an overdose of it is unlikely to cause acute problems. With tetryzoline, acute overdosage shows up as disturbances of the CNS, the heart and the mind, along with mydriasis, cyanosis and fever. CNS functions may be inhibited in some circumstances.
If the product is swallowed by accident and symptoms of intoxication appear, these measures are possible: giving activated charcoal, gastric lavage, artificial ventilation with oxygen, and phentolamine to lower blood pressure (5 mg in saline solution, given i.v.). Vasopressors are contraindicated. Antipyretic and anticonvulsive therapy can be given as necessary.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Fluorometholone + Tetrahydrozoline out of the reach of children. Store it in a cool, dry place, away from heat and direct light. Once you've opened it, don't use it for more than 4 weeks.
Common questions about Refemoline 0.1%+0.025%
What is Refemoline 0.1%+0.025% Ophthalmic Solution?
Refemoline 0.1%+0.025% Ophthalmic Solution is a medicine that contains Fluorometholone + Tetrahydrozoline. It is made by Reman Drug Laboratories Ltd. It belongs to the Ophthalmic Steroid preparations group of medicines.
What is Refemoline used for?
Fluorometholone + Tetrahydrozoline eye drop is used for acute and chronic allergic non-infectious conjunctivitis and keratitis with severe swelling and intravascular injection. It is also used for non-infectious inflammation of the anterior segment of the eye, including anterior uveitis, episcleritis and scleritis.
What are the side effects of Refemoline?
Fluorometholone with tetrahydrozoline can cause a mild burning sensation, a reversible rise in intraocular pressure and reactive hyperemia. Cataract, corneal defects and glaucoma may occur, and with chronic use there can be systemic effects.
Can I take Refemoline during pregnancy or while breastfeeding?
There are no adequate and well-controlled studies of Fluorometholone and Tetrahydrozoline in pregnancy or during breast-feeding. So this combination should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Refemoline?
When this product is used as directed, an overdose is very unlikely. There is no information on overdosage with fluorometholone, and an overdose of it is unlikely to cause acute problems. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Refemoline?
Keep Fluorometholone + Tetrahydrozoline out of the reach of children. Store it in a cool, dry place, away from heat and direct light.
Do I need a prescription for Refemoline?
Refemoline is a prescription (Rx) medicine. Take it as your doctor advises.