Indications & Uses
Reefcal Kit is indicated for:
Pharmacology
Ibandronic Acid (Ibandronate Sodium Monohydrate) is a nitrogen-containing bisphosphonate. It stops osteoclasts from breaking down bone. It works because it binds readily to hydroxyapatite, which is part of the mineral matrix of bone. By reducing osteoclast activity, Ibandronate lowers bone resorption and bone turnover. In postmenopausal women the rate of bone turnover is raised, and Ibandronate brings it down, which leads, on average, to a net gain in bone mass.
The Coral Calcium and Colecalciferol combination is made of Calcium Carbonate with small amounts of Magnesium and other trace minerals. Coral Calcium is absorbed better than Calcium from other Calcium Carbonate sources, because its chemical structure is very close to the Calcium Carbonate in human bone. Vitamin D helps the body absorb Calcium from the GI tract and helps keep the Calcium balance in the body steady.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended dose is one tablet of Ibandronic Acid 150 mg once a month, on the same date each month. To get the most clinical benefit from Ibandronic Acid, two tablets of Calcium 500 mg and Vitamin D3 200 IU per day are usually recommended, in divided doses or as the physician directs. On Day 1, take the Ibandronic Acid tablet on an empty stomach, at least 60 minutes before the first food or drink of the day (other than water) and before any oral medicine or supplement, including Calcium, antacid and/or vitamins. Swallow the tablet whole with a glass of plain water, either standing or sitting upright. Avoid lying down for 60 minutes. Do not chew or suck the tablet. From Day 2 to 31, take one tablet of Calcium and Vitamin D in the morning and one in the evening, after meals. Take the tablets in the order shown on the blister strip, which makes it easier to keep track of doses. In pediatric patients, safety and effectiveness have not been established.
Side Effects
Ibandronic Acid is the bisphosphonate in this combination. Its common side effects include hypertension, dyspepsia, nausea, diarrhea, abdominal pain, arthralgia, back pain, localized osteoarthritis, myalgia, muscle cramp, influenza, nasopharyngitis, bronchitis, urinary tract infection, upper respiratory tract infection, headache, dizziness, skin rash and insomnia, among others. The calcium and vitamin D3 part most often causes flatulence, diarrhea, constipation and upper GI discomfort, and similar complaints. Hypercalciuria and hypercalcemia have rarely been reported after prolonged use.
Cautions & Contraindications
Warnings & Precautions
Ibandronic acid: Upper gastrointestinal adverse reactions Like other bisphosphonates taken by mouth, ibandronic acid may irritate the lining of the upper gastrointestinal tract. Because of this, be careful when giving it to patients who already have active upper gastrointestinal problems, such as known Barrett's esophagus, dysphagia, other esophageal diseases, gastritis, duodenitis or ulcers. Hypocalcaemia and mineral metabolism Hypocalcemia and other disturbances of bone and mineral metabolism should be treated before therapy starts. Musculoskeletal pain Severe and sometimes incapacitating bone, joint and/or muscle pain has been reported in patients taking ibandronic acid and other bisphosphonates. Jaw osteonecrosis Osteonecrosis, mainly in the jaw, has been reported in patients treated with bisphosphonates. Most cases were in cancer patients having dental procedures, but some occurred in patients with postmenopausal osteoporosis or other diagnoses. Calcium and vitamin D In mild hypercalciuria, reducing the dose is enough to bring the serum calcium concentration back to normal. Plasma and serum calcium levels should be monitored in patients with mild to moderate renal impairment, and also when the medicine is used for a long time. Patients who have a renal stone, or have had one before, should be advised to drink more fluids.
Contraindications
Ibandronic Acid should not be used if the person has an abnormality of the esophagus that delays esophageal emptying, such as stricture or achalasia. It is also not for anyone who can't stand or sit upright for at least 60 minutes, or who has hypocalcemia or a known hypersensitivity to Ibandronic Acid. For the Calcium and Vitamin D3 part, the medicine must not be used in people with hypersensitivity to any component of the preparation. It is also contraindicated in hypercalcemia, hyperparathyroidism, hypercalciuria, nephrolithiasis, severe renal insufficiencies, renal calculi and Zollinger Ellison syndrome. Concomitant Digoxin therapy is a contraindication as well, and it requires careful monitoring of the serum calcium level.
Pregnancy & Breastfeeding
Pregnancy category C. There are no adequate and well-controlled studies in pregnant women, so this kit should be used during pregnancy only if the likely benefit justifies the possible risk to the mother and the fetus.
Nursing mother: It is not known whether this kit passes into human milk. Because many drugs do pass into human milk, a nursing woman should be given this kit with caution.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
There's no specific information on how to treat an overdose of Ibandronic acid. Based on what is known about this class of medicines, though, taking too much by mouth may cause low calcium in the blood (hypocalcemia), low phosphate in the blood (hypophosphatemia) and upper gastrointestinal adverse events.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store this medicine at a temperature not above 30°C. Keep it away from light, and make sure children can't reach it.
Drug Interactions
Common questions about Reefcal Kit 150 mg+600 mg+400 IU
What is Reefcal Kit 150 mg+600 mg+400 IU Tablet?
Reefcal Kit 150 mg+600 mg+400 IU Tablet is a medicine that contains Ibandronic Acid + Coral Calcium + Vitamin D3. It is made by Ziska Pharmaceuticals Ltd. It belongs to the Bisphosphonate preparations group of medicines.
What is Reefcal Kit used for?
Reefcal Kit is used for: Osteoporosis.
What are the side effects of Reefcal Kit?
Ibandronic Acid is the bisphosphonate in this combination. Its common side effects include hypertension, dyspepsia, nausea, diarrhea, abdominal pain, arthralgia, back pain, localized osteoarthritis, myalgia, muscle cramp, influenza, nasopharyngitis, bronchitis, urinary tract infection, upper respiratory tract infection, headache, dizziness, skin rash and insomnia, among others.
Can I take Reefcal Kit during pregnancy or while breastfeeding?
Pregnancy category C. There are no adequate and well-controlled studies in pregnant women, so this kit should be used during pregnancy only if the likely benefit justifies the possible risk to the mother and the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Reefcal Kit?
There's no specific information on how to treat an overdose of Ibandronic acid. Based on what is known about this class of medicines, though, taking too much by mouth may cause low calcium in the blood (hypocalcemia), low phosphate in the blood (hypophosphatemia) and upper gastrointestinal adverse events. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Reefcal Kit?
Store this medicine at a temperature not above 30°C. Keep it away from light, and make sure children can't reach it.
Can I take other medicines with Reefcal Kit?
Some medicines can interact with Ibandronic Acid + Coral Calcium + Vitamin D3, for example: Iron, Phenytoin, Ranitidine, Ibandronic Acid, Magnesium, Tetracycline Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Reefcal Kit?
Reefcal Kit is a prescription (Rx) medicine. Take it as your doctor advises.