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Other brands with the same active ingredient
These brands contain the same active ingredient (Ramosetron Hydrochloride). Same strength and form. Confirm the switch with your doctor or pharmacist.
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Other strengths and forms by Popular Pharmaceuticals PLC
Indications & Uses
Ramotic is indicated for:
Pharmacology
Ramosetron Hydrochloride is a serotonin 5-HT3 receptor antagonist. Serotonin is a neurotransmitter that has a strong link with gut movement, secretion and sensation. Stress can trigger the release of serotonin, which activates the 5-HT3 receptors on the enteric nerve. This speeds up the passage of contents through the intestine and results in diarrhea. The rise in pressure inside the colon also releases serotonin, and this binds to the 5-HT3 receptor at the terminal of the afferent neuron. The result is that pain signals from the intestine travel to the central nervous system.
Ramosetron Hydrochloride selectively inhibits the 5-HT3 receptor, and this improves abnormal defecation linked to faster intestinal transit. It also improves visceral hypersensitivity by suppressing the transmission of intestinal nociception. It relieves diarrhea by opposing the effect of serotonin on the 5-HT3 receptors on the efferent nerves. In the same way, it relieves abdominal pain by opposing serotonin at the 5-HT3 receptors on the afferent nerves.
Carcinostatic drugs such as cisplatin make the enterochromaffin cells in the gastrointestinal tract release serotonin. This serotonin binds to the 5-HT3 receptors on the afferent vagal nerve-endings in the gastrointestinal mucosa. The stimulation that follows induces emesis through the vomiting center. Ramosetron Hydrochloride is considered to act as an antiemetic by blocking these 5-HT3 receptors.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Male patients with diarrhea-predominant irritable bowel syndrome: the usual adult dose of Ramosetron Hydrochloride is 5 mcg, taken by mouth once a day. The doctor may adjust it according to the patient's clinical condition, but the daily dose should not go above 10 mcg.
Female patients with diarrhea-predominant irritable bowel syndrome: the usual adult dose is 2.5 mcg of Ramosetron Hydrochloride, taken by mouth once a day. If the patient doesn't respond well enough to the starting dose, it may be increased. The daily dose should not go above 5 mcg.
Side Effects
Constipation and hardened stool are the side effects most often reported with Ramosetron Hydrochloride. Other side effects need more attention. These are facial pallor, cold sweat, dizziness on standing up, sudden abdominal pain, bloody stool and fever.
Cautions & Contraindications
Warnings & Precautions
Use Ramosetron Hydrochloride with caution in people who have constipation, because their condition may get worse. In some cases the doctor may need to take corrective measures, adjust the dose, or switch to a suitable alternative. Be careful in people with liver disease too, as the risk of adverse effects is higher. Their liver function tests should be checked regularly. Depending on the clinical condition, the dose may need adjusting or the medicine may need to be replaced with a suitable alternative. The same caution applies to people with kidney disease, again because of the higher risk of adverse effects. Kidney function tests should be monitored regularly in these patients. Based on the clinical condition, a dose adjustment or a switch to a suitable alternative may be required in some cases.
Pregnancy & Breastfeeding
Doctors should prescribe Ramosetron Hydrochloride during pregnancy only when the expected benefit is greater than the possible risk to the baby. If you are breastfeeding, take care when using Ramosetron Hydrochloride.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Ramos (Ramosetron Hydrochloride) has not been shown to be safe in newborns, infants or children.
Storage
Store Ramosetron Hydrochloride at a temperature not above 30°C. Keep it away from light and from damp places. Keep it out of reach of children.
Drug Interactions
Common questions about Ramotic 2.5 mcg
What is Ramotic 2.5 mcg Tablet?
Ramotic 2.5 mcg Tablet is a medicine that contains Ramosetron Hydrochloride. It is made by Popular Pharmaceuticals PLC. It belongs to the Drugs for Irritable Bowel Syndrome group of medicines.
What is Ramotic used for?
Ramotic is used for: Diarrhea, Irritable Bowel Syndrome.
What are the side effects of Ramotic?
Constipation and hardened stool are the side effects most often reported with Ramosetron Hydrochloride. Other side effects need more attention.
Can I take Ramotic during pregnancy or while breastfeeding?
Doctors should prescribe Ramosetron Hydrochloride during pregnancy only when the expected benefit is greater than the possible risk to the baby. If you are breastfeeding, take care when using Ramosetron Hydrochloride. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Ramotic?
Store Ramosetron Hydrochloride at a temperature not above 30°C. Keep it away from light and from damp places.
Can I take other medicines with Ramotic?
Some medicines can interact with Ramosetron Hydrochloride, for example: Bumetanide, Fluvoxamine Maleate. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Ramotic?
Ramotic is a prescription (Rx) medicine. Take it as your doctor advises.