Pricing
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All price changes →Indications & Uses
R-Lix is indicated for:
Pharmacology
Relugolix is a non-peptide small molecule and a GnRH receptor antagonist. It binds competitively to the GnRH receptors in the pituitary, so less luteinizing hormone (LH) and follicle-stimulating hormone (FSH) is released, and testosterone falls as a result.
Absorption: Relugolix is a substrate for intestinal P-gp. Its mean (CV%) absolute bioavailability is approximately 12%, and the median (range) Tmax is 2.25 hours.
Effect of food: No clinically meaningful differences in the pharmacokinetics of Relugolix were seen after a high-calorie, high-fat meal.
Distribution: Plasma protein binding is 68 to 71%. Most of it is to albumin and a smaller part is to α1-acid glycoprotein. The mean blood-to-plasma ratio is 0.78.
Elimination: The mean effective half-life is 25 hours, and the mean (CV %) terminal elimination half-life is 60.8 (11%) hours. Mean (CV %) total clearance is 29.4 (15%) L/h, and renal clearance is 8 L/h.
Metabolism: In vitro, Relugolix is metabolized mainly by CYP3A and, to a lesser extent, by CYP2C8.
Excretion: After a single oral 80mg radiolabeled dose, approximately 81% of the radioactivity was recovered in feces (4.2% as unchanged drug) and 4.1% in urine (2.2% as unchanged drug).
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Start Relugolix with a loading dose of 360 mg on the first day. After that, the dose is 120 mg once daily, taken at about the same time each day. Relugolix Tablet can be taken with or without food.
A patient who misses a dose should take it as soon as they remember. But when the dose is more than 12 hours late, they should skip it and carry on with the next scheduled dose. Treatment interrupted for more than 7 days needs a fresh start: give the 360 mg loading dose on the first day, then continue with 120 mg once daily.
Pediatric Use: The safety and efficacy of Relugolix in pediatric patients have not been established.
Geriatric Use: No overall differences in safety or effectiveness were observed between older and younger subjects.
Side Effects
With relugolix, the most common adverse reactions (≥10%) and laboratory abnormalities (≥15%) were hot flushes, increased glucose, increased triglycerides, musculoskeletal pain, decreased haemoglobin, increased alanine aminotransferase (ALT), fatigue, increased aspartate aminotransferase (AST), constipation and diarrhoea. In plain terms, the common side effects are hot flushes, higher blood sugar levels, higher blood fat (triglyceride) levels, muscle and joint pain, lower haemoglobin levels, raised liver enzymes, tiredness, constipation and diarrhoea. Relugolix may also cause some rare side effects. These include changes in the electrical activity of your heart (QT prolongation), dizziness, fainting, a feeling that your heart is pounding or racing (palpitations) and chest pain. Other side effects include weight gain, decreased sex drive and erectile function problems.
Cautions & Contraindications
Warnings & Precautions
QT/QTc interval prolongation Androgen deprivation therapy may prolong the QT interval. Embryo-fetal toxicity Relugolix can cause fetal harm. Men who have female partners able to become pregnant should be advised to use effective contraception.
Pregnancy & Breastfeeding
Relugolix has not been shown to be safe or effective in females at the recommended dose of 120 mg daily.
Females and Males of Reproductive Potential
Animal findings and the way Relugolix works suggest it may impair fertility in males of reproductive potential.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Doctors have no specific experience in managing an overdose of Relugolix in patients.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Relugolix in a cool, dry place, away from light and moisture. As with all medicines, keep it out of the reach of children.
Drug Interactions
Common questions about R-Lix 120 mg
What is R-Lix 120 mg Tablet?
R-Lix 120 mg Tablet is a medicine that contains Relugolix. It is made by Eskayef Pharmaceuticals Ltd. It belongs to the Gonadotropin-releasing hormone (GnRH) antagonist group of medicines.
What is R-Lix used for?
R-Lix is used for: Cancer.
What are the side effects of R-Lix?
With relugolix, the most common adverse reactions (≥10%) and laboratory abnormalities (≥15%) were hot flushes, increased glucose, increased triglycerides, musculoskeletal pain, decreased haemoglobin, increased alanine aminotransferase (ALT), fatigue, increased aspartate aminotransferase (AST), constipation and diarrhoea. In plain terms, the common side effects are hot flushes, higher blood sugar levels, higher blood fat (triglyceride) levels, muscle and joint pain, lower haemoglobin levels, raised liver enzymes, tiredness, constipation and diarrhoea.
Can I take R-Lix during pregnancy or while breastfeeding?
Relugolix has not been shown to be safe or effective in females at the recommended dose of 120 mg daily. Females and Males of Reproductive Potential Animal findings and the way Relugolix works suggest it may impair fertility in males of reproductive potential. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much R-Lix?
Doctors have no specific experience in managing an overdose of Relugolix in patients. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store R-Lix?
Keep Relugolix in a cool, dry place, away from light and moisture. As with all medicines, keep it out of the reach of children.
Can I take other medicines with R-Lix?
Some medicines can interact with Relugolix, for example: Relugolix + Estradiol + Norethindrone. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
R-Lix is already among the lowest-priced brands of Relugolix at this strength.
Do I need a prescription for R-Lix?
R-Lix is a prescription (Rx) medicine. Take it as your doctor advises.