More from Pyroxin
Other strengths and forms by G. A. Company Ltd.
Indications & Uses
Pyroxin is indicated for:
Pharmacology
Vitamin B6 (pyridoxine) is a water-soluble vitamin used to prevent and treat vitamin B6 deficiency and the peripheral neuropathy that can occur in people taking isoniazid (isonicotinic acid hydrazide, INH). In a small group of subjects with essential hypertension, vitamin B6 was found to lower both systolic and diastolic blood pressure. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study, again in a small group of subjects, showed that pyridoxine hydrochloride inhibits ADP or epinephrine induced platelet aggregation and lowers total cholesterol while raising HDL cholesterol. Vitamin B6, in the form of pyridoxal 5'-phosphate, was also found to protect cultured vascular endothelial cells from injury caused by activated platelets. Endothelial injury and dysfunction are critical initiating events in the development of atherosclerosis. Human studies have shown that vitamin B6 deficiency affects both the cellular and humoral responses of the immune system. Such deficiency can alter lymphocyte differentiation and maturation, reduce delayed type hypersensitivity (DTH) responses, impair antibody production, and lower lymphocyte proliferation and interleukin (IL) 2 production, among other immunologic effects.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Oral use. For general deficiency states, up to 150 mg (6 tablets) daily. For sideroblastic anaemias, up to 400 mg (16 tablets) daily. For premenstrual syndrome, 50 to 100 mg (2 to 4 tablets) daily. For peripheral neuritis, prophylaxis is 10 to 50 mg (2 tablets) daily, and treatment is 100 to 200 mg (4 to 8 tablets) daily.
Side Effects
Taking pyridoxine in large doses (more than about 2 g a day) over a long period has been linked to severe peripheral neuropathy (nerve damage in the hands and feet). Very high doses may also lower folate levels in the blood.
Cautions & Contraindications
Warnings & Precautions
Pyridoxine (Pyrovit) can reduce the effectiveness of levodopa; however, this interaction does not occur when levodopa is given together with a dopa decarboxylase inhibitor. A number of medicines may affect how pyridoxine is metabolised or absorbed, including isoniazid, penicillamine and oral contraceptives.
Contraindications
Pyridoxine should not be given to patients who are receiving levodopa for Parkinson's disease. At doses of 80 to 400 mg daily, pyridoxine has been reported to increase the hepatic metabolism of phenobarbitone or phenytoin by 40 to 50% in some patients, which lowers the serum concentration of these drugs.
Pregnancy & Breastfeeding
Pyridoxine needs tend to rise during pregnancy, and it is sometimes useful for easing pregnancy-related nausea and vomiting. Requirements also increase during breastfeeding, so pyridoxine should be given to a nursing mother with caution.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
If you take more Pyridoxine Hydrochloride tablets than you should
If you take too many tablets by accident, contact your doctor, your pharmacist or the nearest hospital casualty department. Take this leaflet and any tablets that are left with you, so the doctor or pharmacist can see them.
If you miss a dose
If you forget a dose, take another one as soon as you remember. But if it's almost time for your next dose, don't take the missed one at all. Never take a double dose to make up for a forgotten tablet.
Stopping the tablets
Keep taking these tablets for as long as your doctor tells you to. Don't stop the medicine without talking to your doctor first.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Pyridoxine Hydrochloride at normal room conditions, between 15°C and 30°C. Protect it from light.
Drug Interactions
Common questions about Pyroxin 100 mg/ml
What is Pyroxin 100 mg/ml Injection?
Pyroxin 100 mg/ml Injection is a medicine that contains Pyridoxine Hydrochloride. It is made by G. A. Company Ltd. It belongs to the Vitamin-B preparations group of medicines.
What is Pyroxin used for?
Pyroxin is used for: Epilepsy, Depression.
What are the side effects of Pyroxin?
Taking pyridoxine in large doses (more than about 2 g a day) over a long period has been linked to severe peripheral neuropathy (nerve damage in the hands and feet). Very high doses may also lower folate levels in the blood.
Can I take Pyroxin during pregnancy or while breastfeeding?
Pyridoxine needs tend to rise during pregnancy, and it is sometimes useful for easing pregnancy-related nausea and vomiting. Requirements also increase during breastfeeding, so pyridoxine should be given to a nursing mother with caution. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Pyroxin?
If you take more Pyridoxine Hydrochloride tablets than you should If you take too many tablets by accident, contact your doctor, your pharmacist or the nearest hospital casualty department. Take this leaflet and any tablets that are left with you, so the doctor or pharmacist can see them. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Pyroxin?
Keep Pyridoxine Hydrochloride at normal room conditions, between 15°C and 30°C. Protect it from light.
Can I take other medicines with Pyroxin?
Some medicines can interact with Pyridoxine Hydrochloride, for example: Pyridoxine Hydrochloride + Doxylamine Succinate, Vitamin B6, B9 & B12, Levodopa, Penicillamine, Vitamin B complex, Vitamin B Complex + Zinc. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Pyroxin?
Pyroxin is a prescription (Rx) medicine. Take it as your doctor advises.