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All price changes →Indications & Uses
This infusion of Amino Acid, Dextrose & Eloctrolytes is used as a source of amino acids in many clinical conditions. It is given when a patient cannot take in enough nutrition by mouth, or when it is not advisable to use the oral route for nutrition.
Pharmacology
Amino Acid, Dextrose & Electrolytes is a sterile, hypertonic and non-pyrogenic solution that contains amino acids, electrolytes and dextrose. Nitrogen balance improves when amino acid injections are given together with a suitable source of calories (for example dextrose, fructose or sorbitol). The body uses nitrogen best when the calories supplied meet its metabolic needs, and this usually means at least 168 kJ/kg/day (40 kcal/kg/day).
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The total daily dose of Amino Acid, Dextrose & Electrolytes depends on the patient's metabolic requirement and how the patient responds clinically. The nitrogen content and caloric values of this infusion are as follows: Amino Acid Chamber (250 ml): 4.2 g. Dextrose Chamber (250 ml): 710 Kj (170 Kcal).
Recommended dietary allowances of protein range from approximately 0.8 g/Kg of body weight for adults to 2.2 g/Kg for infants. Daily amino acid doses of approximately 1.0 to 1.5 g/Kg of body weight for adults, and 2 to 3 g/Kg of body weight for infants, are generally enough to meet protein needs and promote positive nitrogen balance, provided calories are adequate.
In fluid restricted patients (eg. Renal failure), the acceptable total daily volume depends on the fluid balance the patient needs. Depending on the clinical condition, approximately 3 litres of solution may be given in a 24 hour period. When it is used after an operation, therapy should begin with 1000 ml on the first post-operative day. After that, the dose may be increased to 3000 ml per day.
Side Effects
There is always a risk of sepsis while parenteral nutrition solutions are being given. Contaminated solutions and infusion catheters can both be sources of infection, so the solution must be prepared, and the catheter placed and looked after, under controlled aseptic conditions. If fever develops, change the solution, its delivery system and the site of the indwelling catheter. Use the prepared amino acid/dextrose admixture immediately. If it has to be stored, keep it in a refrigerator for a short time only, preferably less than 24 hours. These metabolic complications have been reported: metabolic acidosis, hypophosphatemia, alkalosis, hyperglycemia and glycosuria, osmotic diuresis and dehydration, rebound hypoglycemia, elevated liver enzymes, hypo and hypervitaminosis, electrolyte imbalances and hyperammonemia.
Cautions & Contraindications
Warnings & Precautions
Amino Acid, Dextrose & Electrolytes injection should be given only by someone who understands fluid and electrolyte balance and nutrition, and who has the clinical skill to recognise and treat any complications that may occur. Giving this solution by IV can cause fluid or solute overload, which leads to hyperosmolal or hypoosmolal states. The risk of hypoosmolal states is especially high in conditions associated with ADH secretion, and it rises with the infusion rate. In a patient with hepatic insufficiency, amino acid solution may cause serum amino acid imbalances, hyperammonemia, stupor and coma, so patients with known or suspected hepatic dysfunction should be given conservative doses. If symptoms of hyperammonemia develop, stop the administration and reassess the patient's clinical status. When renal function is impaired, amino acid solution raises special problems because electrolytes are retained. Don't give this solution at the same time as blood through the same infusion set, because pseudoagglutination is possible. The injection may cause hyperglycemia, glycosuria and hyperosmolar syndrome, so blood and urine glucose should be monitored routinely in patients on this therapy. Parenteral nutrition mixtures should be withdrawn slowly, because stopping a concentrated dextrose solution suddenly may cause rebound hypoglycemia as the body keeps producing its own insulin. Take special care when giving hypertonic dextrose to patients with impaired glucose tolerance, such as diabetics, prediabetics and uremic patients. Handling of a glucose load is also often impaired in patients with liver failure. Use caution when giving this injection to patients who are receiving corticosteroids or corticotropin.
Contraindications
Don't give this to patients with acute renal failure, or to those with severe liver disease or hepatic coma. It's also not for anyone who is hypersensitive to one or more of the amino acids, or who has an inborn error of amino acid metabolism involving one or more of the amino acid components.
Pregnancy & Breastfeeding
No animal reproduction studies have been done with amino acid injections. So it isn't known whether they can harm the unborn baby when given to a pregnant woman, or whether they can affect a woman's ability to reproduce. A pregnant woman should be given amino acid injections only if they are clearly needed.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Amino Acid, Dextrose & Electrolytes below 30°C. Keep it away from sunlight and don't let it freeze. Keep it out of reach of children.
Once the amino acids/dextrose admixture has been prepared, give it straight away. If that isn't possible, keep it in a refrigerator (2 to 8°C) and use it within 24 hours.
Leave the unit in its overwrap until you are ready to use it. The overwrap works as an oxygen and U.V. barrier, and the inner bag keeps the product sterile.
Drug Interactions
Common questions about Protinex Ultra 5%+10%
What is Protinex Ultra 5%+10% IV Infusion?
Protinex Ultra 5%+10% IV Infusion is a medicine that contains Amino Acid, Dextrose & Eloctrolytes. It is made by Eskayef Pharmaceuticals Ltd. It belongs to the Parenteral nutritional preparations group of medicines.
What is Protinex Ultra used for?
This infusion of Amino Acid, Dextrose & Eloctrolytes is used as a source of amino acids in many clinical conditions. It is given when a patient cannot take in enough nutrition by mouth, or when it is not advisable to use the oral route for nutrition.
What are the side effects of Protinex Ultra?
There is always a risk of sepsis while parenteral nutrition solutions are being given. Contaminated solutions and infusion catheters can both be sources of infection, so the solution must be prepared, and the catheter placed and looked after, under controlled aseptic conditions.
Can I take Protinex Ultra during pregnancy or while breastfeeding?
No animal reproduction studies have been done with amino acid injections. So it isn't known whether they can harm the unborn baby when given to a pregnant woman, or whether they can affect a woman's ability to reproduce. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Protinex Ultra?
Store Amino Acid, Dextrose & Electrolytes below 30°C. Keep it away from sunlight and don't let it freeze.
Can I take other medicines with Protinex Ultra?
Some medicines can interact with Amino Acid, Dextrose & Eloctrolytes, for example: Amino Acid. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Protinex Ultra?
Protinex Ultra is a prescription (Rx) medicine. Take it as your doctor advises.