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Indications & Uses
Primidone 250 mg is indicated for:
Pharmacology
Primidone raises the seizure threshold in experimental animals, whether the seizures are brought on by electric shock or by chemicals, and it also changes the pattern of seizures. How primidone works against epilepsy is not known. The medicine has anticonvulsant activity of its own, and so do its two metabolites, phenobarbital and phenylethylmalonamide (PEMA). PEMA has anticonvulsant activity too, and in experimental animals it also strengthens the anticonvulsant activity of phenobarbital.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Patients 8 years of age and older who have received no previous treatment may be started on primidone tablets in the following way. Give 100 to 125 mg at bedtime on days 1 to 3, then 100 to 125 mg twice a day on days 4 to 6. Days 7 to 9 call for 100 to 125 mg three times a day. From day 10 into maintenance, the dose is 250 mg three times a day.
For most adults and children 8 years of age and over, the usual maintenance dosage is three to four 250 mg tablets in divided doses (250 mg three times a day or four times a day). If required, the dose can be raised to five or six 250 mg tablets daily, but daily doses should not exceed 500 mg four times a day. The dosage should be individualized so the patient gets the most benefit. In some cases, serum blood level tests for primidone may be necessary to adjust the dose properly. The clinically effective serum level is between 5 to 12 mcg/mL.
Side Effects
The early side effects seen most often with primidone are ataxia and vertigo. These usually settle as treatment continues, or when the starting dose is reduced. Now and then, people have reported nausea, anorexia, vomiting, fatigue, hyperirritability, emotional disturbances, sexual impotency, diplopia, nystagmus, drowsiness and morbilliform skin eruptions. Granulocytopenia, agranulocytosis, and red-cell hypoplasia and aplasia have been reported rarely. If any of these occur, or if other side effects are persistent or severe, the medicine may need to be withdrawn. Megaloblastic anemia can occur as a rare idiosyncrasy to Rimidon and to other anticonvulsants. It responds to folic acid, so the medicine does not have to be stopped.
Cautions & Contraindications
Warnings & Precautions
The total daily dose of Rimidon should not go above 2 g. Treatment with Rimidon usually continues for a long time, so a complete blood count and a sequential multiple analysis-12 (SMA-12) test should be done every 6 months.
Pregnancy & Breastfeeding
We don't know what Primidone does in human pregnancy or in nursing infants. What is known is that in mothers treated with primidone, the drug passes into breast milk in substantial quantities.
Testing for primidone in body fluids is too complex for the average clinical laboratory, so it can't be used to check the baby. Instead, if a nursing newborn of a mother taking Primidone becomes unduly sleepy or drowsy, that should be taken as a sign that nursing should be stopped.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Primidone below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Primidone 250 mg 250 mg
What is Primidone 250 mg 250 mg Tablet?
Primidone 250 mg 250 mg Tablet is a medicine that contains Primidone. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Adjunct anti-epileptic drugs group of medicines.
What is Primidone 250 mg used for?
Primidone 250 mg is used for: Epilepsy.
What are the side effects of Primidone 250 mg?
The early side effects seen most often with primidone are ataxia and vertigo. These usually settle as treatment continues, or when the starting dose is reduced.
Can I take Primidone 250 mg during pregnancy or while breastfeeding?
We don't know what Primidone does in human pregnancy or in nursing infants. What is known is that in mothers treated with primidone, the drug passes into breast milk in substantial quantities. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Primidone 250 mg?
Store Primidone below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Primidone 250 mg?
Some medicines can interact with Primidone, for example: Folinic Acid, Deflazacort, Dexamethasone, Lamotrigine, Lynestrenol, Posaconazole. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Primidone 250 mg?
Primidone 250 mg is a prescription (Rx) medicine. Take it as your doctor advises.