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Indications & Uses
Pravalip is indicated for:
Pharmacology
Pravastatin is a specific inhibitor of hepatic HMG-CoA reductase in humans. This enzyme works at an early, rate-limiting step in cholesterol biosynthesis, so blocking it reduces the amount of cholesterol the body makes.
The fall in cholesterol synthesis has been observed to increase the number of LDL receptors on cell surfaces. It also improves receptor-mediated metabolism and clearance of LDL. On the other hand, pravastatin inhibits LDL production, and that in turn inhibits hepatic synthesis of VLDL, because LDL is the precursor for these molecules.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
General Dosing Information
Before pravastatin is started, the patient should be placed on a standard cholesterol-lowering diet. The patient should stay on that diet throughout treatment with pravastatin.
Adult Patients
The recommended starting dose is 40 mg once daily. If 40 mg a day doesn't bring cholesterol to the desired level, 80 mg once daily is recommended. In patients with significant renal impairment, the recommended starting dose is 10 mg daily. Pravastatin can be taken by mouth as a single dose at any time of the day, with or without food. The maximal effect of a given dose is seen within 4 weeks, so lipid levels should be checked periodically at that point. The dose is then adjusted according to the patient's response to therapy and established treatment guidelines.
Children (Ages 8 to 13 Years)
The recommended dose is 20 mg once daily for children 8 to 13 years of age. Doses greater than 20 mg have not been studied in this patient population.
Adolescents (Ages 14 to 18 Years)
The recommended starting dose is 40 mg once daily for adolescents 14 to 18 years of age. Doses greater than 40 mg have not been studied in this patient population. Children and adolescents treated with pravastatin should be reevaluated in adulthood, and their cholesterol-lowering regimen should be changed as appropriate to achieve adult goals for LDL-C.
Side Effects
In short-term clinical trials with pravastatin sodium, the side effects reported most often were musculoskeletal pain, nausea or vomiting, upper respiratory infection, diarrhea and headache. These were reported by at least 2% of people and more often than with placebo, whatever the cause was thought to be.
Cautions & Contraindications
Warnings & Precautions
Skeletal muscle effects, such as myopathy and rhabdomyolysis, are more likely in people with certain risk factors. These include advanced age (over 65), uncontrolled hypothyroidism and renal impairment. Patients should be told to report any symptoms of myopathy promptly. If myopathy is diagnosed or suspected, Pravastatin Sodium should be stopped. Liver enzyme abnormalities can also occur, and persistent rises in hepatic transaminases are possible. Liver enzyme tests should be checked before starting Pravastatin Sodium and again later whenever clinically indicated.
Contraindications
Don't give Pravastatin Sodium to anyone who is hypersensitive to any of its components, or who has active liver disease or unexplained, persistent raised serum transaminases. It is also not for women who are pregnant or may become pregnant, or for nursing mothers.
Pregnancy & Breastfeeding
Pravastatin is Pregnancy Category X, and its safety in pregnant women has not been established. Some women have taken it by accident while pregnant, and the data on them don't point to any harmful clinical events. But there are no adequate and well-controlled studies in pregnant women. So nobody knows whether pravastatin can harm the fetus when given to a pregnant woman, or whether it can affect reproductive capacity.
Pravastatin should be used in pregnancy only if the likely benefit is greater than the possible risk to the fetus, and only after the patient has been told about the potential hazards.
A small amount of pravastatin passes into human breast milk. Because this could cause serious adverse reactions in a nursing infant, women taking pravastatin should not nurse.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Pravastatin Sodium below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Pravalip 10 mg
What is Pravalip 10 mg Tablet?
Pravalip 10 mg Tablet is a medicine that contains Pravastatin Sodium. It is made by Navana Pharmaceuticals Ltd. It belongs to the Other Anti-anginal & Anti-ischaemic drugs group of medicines.
What is Pravalip used for?
Pravalip is used for: Hyperlipidemia, Stroke.
What are the side effects of Pravalip?
In short-term clinical trials with pravastatin sodium, the side effects reported most often were musculoskeletal pain, nausea or vomiting, upper respiratory infection, diarrhea and headache. These were reported by at least 2% of people and more often than with placebo, whatever the cause was thought to be.
Can I take Pravalip during pregnancy or while breastfeeding?
Pravastatin is Pregnancy Category X, and its safety in pregnant women has not been established. Some women have taken it by accident while pregnant, and the data on them don't point to any harmful clinical events. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Pravalip?
Store Pravastatin Sodium below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Pravalip?
Some medicines can interact with Pravastatin Sodium, for example: Bempedoic Acid, Bempedoic Acid + Ezetimibe, Cyclosporine, Niacin, Clarithromycin, Resmetirom. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Pravalip is already among the lowest-priced brands of Pravastatin Sodium at this strength.
Do I need a prescription for Pravalip?
Pravalip is a prescription (Rx) medicine. Take it as your doctor advises.