Pricing
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Pradox is indicated for:
Pharmacology
Pralidoxime Chloride is an acetylcholinesterase reactivator. Its main job is to bring back acetylcholinesterase, mostly outside the central nervous system, after an organophosphate pesticide or a related compound has inactivated it by phosphorylation. Once the enzyme is working again, the build-up of acetylcholine can be broken down, and the neuromuscular junctions can start working normally again.
Pralidoxime Chloride also slows the "aging" of phosphorylated cholinesterase into a form that can no longer be reactivated. It can also break down certain organophosphates through a direct chemical reaction.
The drug works most reliably in relieving paralysis of the muscles used for breathing. Atropine must always be given along with it, because atropine blocks the effect of the acetylcholine that has built up at that site.
The drug reaches the minimum therapeutic level in plasma (4 µg/ml) about 16 minutes after a 600 mg injection of Pralidoxime Chloride. It is cleared quickly in the urine, partly as the unchanged drug and partly as a metabolite made by the liver.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults and children over 16 years: Give an initial dose of 1000 to 2000 mg of Pralidox (Pralidoxime Chloride), preferably as an infusion in 100 ml of normal saline over 15 to 30 minutes. If this is not practical, or if pulmonary oedema is present, give the dose slowly by intravenous injection (over not less than 5 minutes) as a 50 mg/ml solution (for example, 1000 mg in 20 ml). A second dose of 1000 to 2000 mg may be needed after about one hour if muscle weakness has not been relieved. Further doses may be given every 10 to 12 hours if muscle weakness persists.
Children 16 years and under: Loading dose: 20 to 50 mg/kg (maximum 2000 mg per dose) over 15 to 30 minutes. Maintenance infusion: 10 to 20 mg/kg per hour. Alternatively, a repeat bolus of 20 to 50 mg/kg (maximum 2000 mg per dose) may be given after 1 hour and repeated every 10 to 12 hours thereafter, as needed.
Preparation for administration: For intravenous infusion, reconstitute a single Pralidox (Pralidoxime Chloride) 1000 mg vial by adding 20 ml of Normal Saline (0.9% Sodium Chloride solution) for Injection using a 10 ml syringe; this gives a concentration of 50 mg/ml. Dilute the solution further with the remaining Normal Saline to reach a concentration of 10 to 20 mg/ml (for example, 1000 mg in 100 ml or 2000 mg in 100 ml). For fluid-restricted patients, or for rapid administration (over at least 5 minutes), a maximum concentration of 50 mg/ml may be used. Discard any unused solution once the dose has been withdrawn.
Side Effects
In a few cases, side effects such as a rapid heartbeat (tachycardia), spasm of the voice box (laryngospasm) and muscle stiffness (rigidity) have been linked to injecting the medicine too quickly.
Cautions & Contraindications
Warnings & Precautions
The following precautions should be kept in mind when treating acetylcholinesterase poisoning, although they do not bear directly on the use of Pralidox. Because barbiturates are potentiated by anticholinesterases, they should be used cautiously in the treatment of convulsions. Morphine, theophylline, aminophylline, succinylcholine, reserpine and phenothiazine-type tranquilizers should be avoided in patients with organophosphate poisoning. Prolonged paralysis has been reported in patients when succinylcholine is given together with drugs that have anticholinesterase activity; it should therefore be used with caution.
Contraindications
Do not use Pralidoxime Chloride if you are allergic (hypersensitive) to pralidoxime or any other ingredient in the product.
Pregnancy & Breastfeeding
Pregnancy Category C. Pralidoxime chloride should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether this medicine passes into breast milk, so it should be used with caution in breastfeeding mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
In normal subjects, these effects have been seen with pralidoxime chloride: dizziness, blurred vision, diplopia, headache, impaired accommodation, nausea and slight tachycardia. Treatment of overdose is artificial respiration, and other supportive therapy should be given as needed.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Pralidoxime Chloride in a cool, dry place and away from light. Store it where children can't reach it.
Drug Interactions
Common questions about Pradox 1000 mg/ml
What is Pradox 1000 mg/ml IV Injection or Infusion?
Pradox 1000 mg/ml IV Injection or Infusion is a medicine that contains Pralidoxime Chloride. It is made by Beacon Pharmaceuticals PLC. It belongs to the Antidote preparations group of medicines.
What is Pradox used for?
Pradox is used for: Depression.
What are the side effects of Pradox?
In a few cases, side effects such as a rapid heartbeat (tachycardia), spasm of the voice box (laryngospasm) and muscle stiffness (rigidity) have been linked to injecting the medicine too quickly.
Can I take Pradox during pregnancy or while breastfeeding?
Pregnancy Category C. Pralidoxime chloride should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Pradox?
In normal subjects, these effects have been seen with pralidoxime chloride: dizziness, blurred vision, diplopia, headache, impaired accommodation, nausea and slight tachycardia. Treatment of overdose is artificial respiration, and other supportive therapy should be given as needed. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Pradox?
Keep Pralidoxime Chloride in a cool, dry place and away from light. Store it where children can't reach it.
Can I take other medicines with Pradox?
Some medicines can interact with Pralidoxime Chloride, for example: Atropine Sulphate. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Pradox?
Pradox is a prescription (Rx) medicine. Take it as your doctor advises.