Indications & Uses
Posaconazole is indicated for:
Pharmacology
Posaconazole stops fungal cells from making ergosterol, which is a key part of the fungal cell membrane. It does this by inhibiting Lanosterol 14-α-demethylase, a cytochrome P-450 dependent enzyme that converts lanosterol to ergosterol in the membrane. When this enzyme is blocked, methylated sterol precursors build up and ergosterol runs low inside the cell membrane. The structure and function of the fungal cell membrane are weakened as a result.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Posaconazole tablets can be taken with or without food. Swallow them whole with water. Don't crush, chew or break them.
Loading dose: 300 mg (3 tablets) twice a day on the first day.
Maintenance dose: 300 mg (3 tablets) once a day from the second day.
The duration of therapy should be based on how severe the underlying disease is, how well the person has recovered from immunosuppression, and the clinical response.
Side Effects
In studies with Posaconazole, the adverse reactions seen most often during treatment were diarrhea, nausea, fever, vomiting, headache, coughing and hypokalemia.
Cautions & Contraindications
Contraindications
Posaconazole is contraindicated in anyone with known hypersensitivity to Posaconazole or to other azole antifungal agents. It must also not be given together with ergot alkaloids, CYP3A4 substrates, terfenadine, astemizole, cisapride, pimozide, halofantrine or quinidine. Taking them together may raise the plasma concentrations of these medicines, which can lead to QTc prolongation and, in rare cases, torsades de pointes. The HMG-CoA reductase inhibitors simvastatin, lovastatin and atorvastatin are also contraindicated with Posaconazole.
Pregnancy & Breastfeeding
Posaconazole should not be used during pregnancy unless the benefit to the mother clearly outweighs the possible risk to the fetus. If a mother is breast-feeding, she must stop once treatment with this medicine begins.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric Use
Safety and effectiveness in pediatric patients below 13 years of age have not been established, so Posac is not recommended for pediatric patients under 13.
Geriatric Use
No dose adjustment is needed for geriatric patients.
Hepatic Impairment
Posac should be used with caution in patients with hepatic impairment. Clinical experience is limited, and Posac plasma levels may be higher in these patients. Liver function tests should be checked at the start of Posac therapy and again during the course of it.
Renal Impairment
No dose adjustment is required in patients with mild renal impairment (eGFR: 50-80 mL/min/1.73 m2) or moderate renal impairment (eGFR: 20-49 mL/min/1.73 m2). Patients with severe renal impairment should be monitored closely for breakthrough fungal infections.
Storage
Keep Posaconazole below 25°C. Keep it out of the reach of children.
Drug Interactions
Common questions about Posaconazole 100 mg
What is Posaconazole 100 mg Tablet?
Posaconazole 100 mg Tablet is a medicine that contains Posaconazole. It is made by Advanced Chemical Industries PLC. It belongs to the Aural Anti-fungal preparations group of medicines.
What is Posaconazole used for?
Posaconazole is used for: Cancer.
What are the side effects of Posaconazole?
In studies with Posaconazole, the adverse reactions seen most often during treatment were diarrhea, nausea, fever, vomiting, headache, coughing and hypokalemia.
Can I take Posaconazole during pregnancy or while breastfeeding?
Posaconazole should not be used during pregnancy unless the benefit to the mother clearly outweighs the possible risk to the fetus. If a mother is breast-feeding, she must stop once treatment with this medicine begins. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Posaconazole?
Keep Posaconazole below 25°C. Keep it out of the reach of children.
Can I take other medicines with Posaconazole?
Some medicines can interact with Posaconazole, for example: Palbociclib, Olaparib, Venetoclax, Brigatinib, Regorafenib Monohydrate, Carbamazepine. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Posaconazole?
Posaconazole is a prescription (Rx) medicine. Take it as your doctor advises.