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Other strengths and forms by Chemist Laboratories Ltd.
Indications & Uses
Pilesnil is indicated for:
Pharmacology
Diosmin and Hesperidin is a phlebotonic drug and a vascular protecting agent. It reinforces venous tone by prolonging the activity of parietal noradrenaline. This decreases venous capacitance, venous distensibility, and venous emptying time. Diosmin and Hesperidin also protects the microcirculation by fighting the processes that damage it. It combats venous inflammation by lowering leukocyte activation, which reduces the release of inflammatory mediators, mainly free radicals and prostaglandins. As a result, it normalizes capillary permeability and strengthens capillary resistance. Diosmin and Hesperidin acts on the lymphatic system too, improving lymphatic drainage by increasing lymph flow and lymph oncotic pressure.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage for Diosmin 450 mg and Hesperidin 50 mg: for acute hemorrhoidal attacks, take 3 tablets twice daily for the first 4 days, then 2 tablets twice daily for three days, and if required 1 tablet twice daily as a maintenance dosage. For chronic hemorrhoids, take 1 tablet twice daily. For chronic venous insufficiency, take 1 tablet twice daily initially for seven days; the duration may be increased depending on severity. Dosage for Diosmin 900 mg and Hesperidin 100 mg: for acute hemorrhoid, take 1 tablet thrice daily for the first 4 days, followed by 1 tablet twice daily for 3 days, and then 1 tablet once daily as a maintenance dose. For relapse of internal hemorrhoid and chronic hemorrhoid, take 1 tablet once daily for 3 months. For chronic venous insufficiency, take 1 tablet once daily for 2 to 6 months. For leg wounds, take 1 tablet once daily for 2 months.
Side Effects
A few cases of minor stomach upset and neurovegetative disturbances (a general feeling of discomfort) have been reported. These do not require stopping the treatment.
Cautions & Contraindications
Warnings & Precautions
If hemorrhoidal symptoms have not cleared within 15 days, the patient should seek medical advice. Diosmin (up to 900 mg/day) has been given to a small number of breast cancer patients with lymphedema following surgery and nodal irradiation; arm swelling was reduced, but there was no effect on the cancer itself. Animal studies and more than 20 years of clinical use in Europe have shown no evidence of carcinogenicity or mutagenicity when the components of Diosmin & Hesperidin are used as recommended. Nonetheless, as a precaution, Diosmin & Hesperidin is not recommended for patients with a history of cancer, since no specific studies have been carried out in this group.
Contraindications
Chronic venous insufficiency and its complications should be diagnosed by a physician, who should also monitor treatment. This product must not be used by anyone who is hypersensitive to any of its ingredients.
Pregnancy & Breastfeeding
Studies done in animals have not shown any birth defects linked to this medicine. No harmful effect in human beings has been reported so far. Because there is no data on whether the medicine passes into breast milk, breastfeeding is not recommended while you are taking it.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Diosmin + Hesperidin below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Common questions about Pilesnil 450 mg
What is Pilesnil 450 mg Tablet?
Pilesnil 450 mg Tablet is a medicine that contains Diosmin + Hesperidin. It is made by Chemist Laboratories Ltd. It belongs to the Phlebotonic & Vascular protecting preparation group of medicines.
What is Pilesnil used for?
Pilesnil is used for: Pain.
What are the side effects of Pilesnil?
A few cases of minor stomach upset and neurovegetative disturbances (a general feeling of discomfort) have been reported. These do not require stopping the treatment.
Can I take Pilesnil during pregnancy or while breastfeeding?
Studies done in animals have not shown any birth defects linked to this medicine. No harmful effect in human beings has been reported so far. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Pilesnil?
Store Diosmin + Hesperidin below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Do I need a prescription for Pilesnil?
Pilesnil is a prescription (Rx) medicine. Take it as your doctor advises.