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Indications & Uses
Pancreatin [High Lipase] is used to treat exocrine pancreatic insufficiency. This can be due to cystic fibrosis, chronic pancreatitis, pancreatectomy or other conditions.
Pharmacology
Pancreatin contains pancreatic enzymes that break down food in the duodenum and the proximal small intestine. They split fats into monoglyceride, glycerol and free fatty acids. Proteins are broken into peptides and amino acids, and starches into dextrins and short chain sugars such as maltose and maltriose. In this way pancreatin does the same work as the digestive enzymes the pancreas normally secretes.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Infants (up to 12 months): Pancreatin may be given at 2,000 to 4,000 lipase units per 120 mL of formula or per breast-feeding. Don't mix the contents of the capsule directly into formula or breast milk before giving it.
Children older than 12 months and younger than 4 years: Start with 1,000 lipase units/kg of body weight per meal for children under 4 years. The maximum is 2,500 lipase units/kg of body weight per meal (or no more than 10,000 lipase units/kg of body weight per day), or less than 4,000 lipase units/g fat ingested per day.
Children 4 years and older and adults: Start with 500 lipase units/kg of body weight per meal for those older than 4 years. The maximum is 2,500 lipase units/kg of body weight per meal (or no more than 10,000 lipase units/kg of body weight per day), or less than 4,000 lipase units/g fat ingested per day.
Administration: Pancreatin is not interchangeable with any other pancrelipase product. Swallow it whole. For infants or patients who can't swallow intact capsules, the contents may be given without crushing or chewing, followed by fluid so that all of it is swallowed.
Side Effects
Pancreatin [High Lipase] contains pancrelipase, and the most serious reactions reported with the different pancreatic enzyme products made from this same ingredient are fibrosing colonopathy, hyperuricemia and allergic reactions.
Cautions & Contraindications
Warnings & Precautions
Fibrosing colonopathy Fibrosing colonopathy has been reported after treatment with different pancreatic enzyme products. It is a rare but serious adverse reaction. It was first described with high-dose pancreatic enzyme use, usually over a long period, and it is most often reported in children with cystic fibrosis. Potential for irritation to oral mucosa Pancreatin [High Lipase] should not be crushed or chewed, and it should not be mixed with foods that have a pH greater than 4. Doing any of these can break down the protective enteric coating. That may cause the enzymes to be released too early, irritate the lining of the mouth, and/or reduce the enzyme activity. Potential for risk of hyperuricemia Potential viral exposure from the product source Allergic reaction
Pregnancy & Breastfeeding
Pregnancy category C. No animal reproduction studies have been done with pancrelipase, and it isn't known whether pancrelipase can harm the baby when given to a pregnant woman, or whether it can affect the ability to have children. The risk and the benefit should be weighed against the need to give a pregnant woman with exocrine pancreatic insufficiency enough nutritional support. Patients should tell their healthcare professional if they are pregnant or thinking of becoming pregnant while being treated with Pancreatin.
Nursing mothers: It isn't known whether pancrelipase passes into human milk. Patients should tell their healthcare professional if they are breast-feeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
No overdose has been reported in clinical trials of Pancreatin [High Lipase]. The same is true for other pancreatic enzyme products, in both clinical trials and postmarketing surveillance. Taking high doses over a long period has been linked with fibrosing colonopathy. High doses have also been linked with hyperuricosuria and hyperuricemia, so these products should be used with caution in patients who have a history of hyperuricemia, gout or renal impairment.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Pancreatin [High Lipase] below 25°C in a dry place, away from light and moisture. Keep it out of the reach of children.
Common questions about Panzest 25000 300 mg
What is Panzest 25000 300 mg Capsule (Enteric Coated)?
Panzest 25000 300 mg Capsule (Enteric Coated) is a medicine that contains Pancreatin [High Lipase]. It is made by Everest Pharmaceuticals Ltd. It belongs to the Digestive Enzyme group of medicines.
What is Panzest 25000 used for?
Pancreatin [High Lipase] is used to treat exocrine pancreatic insufficiency. This can be due to cystic fibrosis, chronic pancreatitis, pancreatectomy or other conditions.
What are the side effects of Panzest 25000?
Pancreatin [High Lipase] contains pancrelipase, and the most serious reactions reported with the different pancreatic enzyme products made from this same ingredient are fibrosing colonopathy, hyperuricemia and allergic reactions.
Can I take Panzest 25000 during pregnancy or while breastfeeding?
Pregnancy category C. No animal reproduction studies have been done with pancrelipase, and it isn't known whether pancrelipase can harm the baby when given to a pregnant woman, or whether it can affect the ability to have children. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Panzest 25000?
No overdose has been reported in clinical trials of Pancreatin [High Lipase]. The same is true for other pancreatic enzyme products, in both clinical trials and postmarketing surveillance. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Panzest 25000?
Keep Pancreatin [High Lipase] below 25°C in a dry place, away from light and moisture. Keep it out of the reach of children.
Is there a cheaper medicine with the same ingredient?
Panzest 25000 is already among the lowest-priced brands of Pancreatin [High Lipase] at this strength.
Do I need a prescription for Panzest 25000?
Panzest 25000 is a prescription (Rx) medicine. Take it as your doctor advises.