Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →More from Palopag
Other strengths and forms by Incepta Pharmaceuticals Ltd.
Indications & Uses
Palopag is indicated for:
Pharmacology
Selexipag is a selective, non-prostanoid agonist of the IP prostacyclin receptor, and it is taken by mouth. It is a pale yellow crystalline powder that is practically insoluble in water. In solid form it is very stable, it doesn't absorb moisture and it isn't sensitive to light. Structurally, selexipag is quite different from prostacyclin itself.
In the body, carboxylesterase 1 hydrolyzes selexipag to its active metabolite, which is approximately 37-fold as potent as selexipag. Both selexipag and this metabolite are selective for the IP receptor over the other prostanoid receptors (EP1-4, DP, FP, and TP).
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Start Selexipag at 200 mcg twice daily. Taking it with food may make it easier to tolerate. Then raise the dose by 200 mcg twice daily at weekly intervals, going up to the highest dose the patient can tolerate, with a ceiling of 1600 mcg twice daily. The maintenance dose depends on how well the patient tolerates it.
Side Effects
Selexipag most often causes nausea, diarrhoea, vomiting and headache. Some people also get jaw pain, muscle pain, low appetite and a low RBC count.
Cautions & Contraindications
Warnings & Precautions
Stop Selexipag if the patient develops signs and symptoms of Pulmonary Veno-Occlusive Disease (PVOD).
Pregnancy & Breastfeeding
There are no adequate and well controlled studies of Selexipag in pregnant women. It is not known if Selexipag passes into human milk. For a nursing mother, either Selexipag or breastfeeding should be stopped.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: Safety and effectiveness of Selexipag in pediatric patients have not been established.
Geriatric use: No overall differences have been observed.
Hepatic impairment: For patients with moderate hepatic impairment, the starting dose is 200 mcg once daily. Increase the dose by 200 mcg once daily at weekly intervals to the highest dose the patient can tolerate, up to 1600 mcg. Avoid Selexipag in patients with severe hepatic impairment (Child-Pugh class C).
Overdose
A few people have taken Selexipag in overdose, with doses of up to 3200 mcg. The only effect reported was mild nausea, and it passed quickly. If an overdose happens, the patient should be given supportive treatment as needed.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Selexipag in a dry place, away from light and heat. Keep it out of reach of children.
Drug Interactions
Common questions about Palopag 400 mg
What is Palopag 400 mg Tablet?
Palopag 400 mg Tablet is a medicine that contains Selexipag. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Non-prostanoid IP prostacyclin receptor agonist group of medicines.
What is Palopag used for?
Palopag is used for: Hypertension.
What are the side effects of Palopag?
Selexipag most often causes nausea, diarrhoea, vomiting and headache. Some people also get jaw pain, muscle pain, low appetite and a low RBC count.
Can I take Palopag during pregnancy or while breastfeeding?
There are no adequate and well controlled studies of Selexipag in pregnant women. It is not known if Selexipag passes into human milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Palopag?
A few people have taken Selexipag in overdose, with doses of up to 3200 mcg. The only effect reported was mild nausea, and it passed quickly. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Palopag?
Store Selexipag in a dry place, away from light and heat. Keep it out of reach of children.
Can I take other medicines with Palopag?
Some medicines can interact with Selexipag, for example: Rifampicin, Deferasirox. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Palopag is already among the lowest-priced brands of Selexipag at this strength.
Do I need a prescription for Palopag?
Palopag is a prescription (Rx) medicine. Take it as your doctor advises.