Save on this medicine
Other brands with the same active ingredient
These brands contain the same active ingredient (Oxcarbazepine). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Oxazep
Other strengths and forms by Incepta Pharmaceuticals Ltd.
Indications & Uses
Oxazep is indicated for:
Pharmacology
Oxcarbazepine's effect on seizures comes mainly from its 10-monohydroxy metabolite, known as MHD. It is not fully understood how Oxcarbazepine and MHD prevent seizures, but laboratory studies of nerve cell electrical activity show that they block voltage-sensitive sodium channels. This calms overexcited nerve membranes, slows repeated firing of neurons, and reduces the spread of signals between nerve cells. These actions are believed to play a key role in stopping seizures from spreading through the brain. The drug's anticonvulsant effect may also be helped by an increase in potassium conductance and by changes in the activity of high voltage activated calcium channels. Oxcarbazepine and MHD have not been shown to interact in any meaningful way with the brain's neurotransmitter or receptor sites.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: treatment is started at 600 mg a day, given in two divided doses. Adjunctive therapy: the dose may be raised by no more than 600 mg a day at roughly weekly intervals, to a recommended daily dose of 1200 mg a day. Conversion to monotherapy: the concomitant antiepileptic drug is withdrawn over 3 to 6 weeks, while the maximum dose of oxcarbazepine is reached within 2 to 4 weeks by increments of 600 mg a day at weekly intervals, up to a recommended daily dose of 2400 mg a day. Initiation of monotherapy: the dose is increased by 300 mg a day every third day, up to 1200 mg a day. For patients with a creatinine clearance below 30 mL/min, treatment is started at half the usual starting dose and increased slowly. Pediatrics: treatment is started at 8 to 10 mg/kg a day, given in two divided doses. For patients aged 2 to under 4 years and weighing under 20 kg, a starting dose of 16 to 20 mg/kg a day may be considered. The recommended daily dose depends on the patient's weight. Adjunctive patients aged 2 to 16 years: for patients aged 4 to 16 years, the target maintenance dose should be reached over 2 weeks; for patients aged 2 to under 4 years, the maximum maintenance dose should be reached over 2 to 4 weeks and should not exceed 60 mg/kg a day. Conversion to monotherapy for patients aged 4 to 16 years: the dose may be raised by no more than 10 mg/kg a day at weekly intervals, and the concomitant antiepileptic drugs can be fully withdrawn over 3 to 6 weeks. Initiation of monotherapy for patients aged 4 to 16 years: the dose is increased by 5 mg/kg a day every third day.
Side Effects
Clinical trials show that Leptal is better tolerated than carbamazepine. The most common adverse effects were: Central nervous system: dizziness, diplopia, headache, nystagmus and abnormal gait; GI: nausea, vomiting and abdominal pain; Dermatologic: rash; Serum electrolytes: hyponatremia. Bone marrow suppression and hepatotoxicity, which are associated with carbamazepine, were infrequently reported with Leptal.
Cautions & Contraindications
Warnings & Precautions
Cognitive and neuropsychiatric effects, such as psychomotor slowing, difficulty concentrating, language problems, drowsiness or fatigue, ataxia and gait disturbances, are among the common adverse effects associated with Leptal. Cases of asymptomatic hyponatraemia (low blood sodium) have been reported. Monitoring of serum sodium levels should be considered if the patient is taking other medicines known to lower serum sodium, or if symptoms of hyponatraemia develop, such as nausea, malaise, headache or confusion. Patients with a history of hypersensitivity reaction to carbamazepine should be treated with Leptal only.
Contraindications
Oxcarbazepine must not be given to anyone with a known allergy to Oxcarbazepine, to any of the ingredients in the preparation, or to eslicarbazepine acetate.
Pregnancy & Breastfeeding
Pregnancy Category C. Well-controlled clinical studies in pregnant women are lacking, so Oxcarbazepine should only be used during pregnancy if the potential benefit to the mother outweighs the potential risk to the fetus. Oxcarbazepine also passes into breast milk, with a milk-to-plasma concentration ratio of 0.5, and for this reason it should not be used while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Oxcarbazepine in a dry place at a temperature not above 30°C. Protect it from light and moisture.
Drug Interactions
Common questions about Oxazep 300 mg
What is Oxazep 300 mg Tablet?
Oxazep 300 mg Tablet is a medicine that contains Oxcarbazepine. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Adjunct anti-epileptic drugs group of medicines.
What is Oxazep used for?
Oxazep is used for: Epilepsy.
What are the side effects of Oxazep?
Clinical trials show that Leptal is better tolerated than carbamazepine. The most common adverse effects were: Central nervous system: dizziness, diplopia, headache, nystagmus and abnormal gait; GI: nausea, vomiting and abdominal pain; Dermatologic: rash; Serum electrolytes: hyponatremia.
Can I take Oxazep during pregnancy or while breastfeeding?
Pregnancy Category C. Well-controlled clinical studies in pregnant women are lacking, so Oxcarbazepine should only be used during pregnancy if the potential benefit to the mother outweighs the potential risk to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Oxazep?
Keep Oxcarbazepine in a dry place at a temperature not above 30°C. Protect it from light and moisture.
Can I take other medicines with Oxazep?
Some medicines can interact with Oxcarbazepine, for example: Norethisterone Acetate, Sofosbuvir, Erythromycin, Cimetidine, Cyclosporine, Drospirenone. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Oxazep?
Oxazep is a prescription (Rx) medicine. Take it as your doctor advises.