More from Ovestin
Other strengths and forms by Nuvista Pharma PLC.
Indications & Uses
SRT cream is indicated for estrogen deficiency. During menopause, the amount of estrogen a woman's body produces gradually declines. A shortage of estrogen causes the vaginal wall to become thin and dry, which leads to painful sexual intercourse. SRT cream is used to relieve painful sexual intercourse. It is used in postmenopausal women who have had at least 12 months since their last natural period. If the ovaries are removed surgically (ovariectomy) before menopause, the decrease in estrogen production occurs very abruptly.
Pharmacology
Estriol Cream is a form of Hormone Replacement Therapy (HRT). It contains the female hormone estriol, an estrogen. Around menopause, estriol is applied in the vagina, where it is slowly released and absorbed into the surrounding tissue and the bloodstream. Estriol helps normalize the vaginal epithelium, which in turn restores the normal microflora and physiological pH of the vagina. This increases the resistance of vaginal epithelial cells to infection and inflammation. Compared with other estrogens, estriol is short acting. In the years just before and after menopause, whether natural or surgically induced, estriol can be used to treat symptoms and complaints related to estrogen deficiency. It is particularly used for treating urogenital symptoms.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage
Estriol cream should be used as advised by your physician. Each dose of cream contains 0.5 mg estriol.
For vulvo-vaginal complaints associated with menopause: Initially, one dose of cream per day for 3 weeks. After that, you may only need one dose of cream twice a week.
Before surgery: One dose of cream daily for 2 weeks before the operation.
When having a Pap smear: Your doctor may recommend a daily application of cream for 7 days.
Side Effects
Local irritation or itching of the vagina, swelling and increased tenderness of the breasts, increased vaginal discharge, nausea, and fluid retention in the tissues (usually noticed as swollen ankles or feet) may occur. In most patients these side effects disappear after the first few weeks of treatment. Tell your doctor if vaginal bleeding occurs, or if any side effect becomes troublesome or persists. Other side effects that may occur with HRT include benign and malignant hormone-dependent tumours such as endometrial cancer; heart attack and stroke; gall bladder disease; skin problems such as rashes, discoloration or red patches on the skin, various skin diseases with blisters and nodules, or bleeding into the skin; and venous thromboembolism, deep vein thrombosis of the leg or pelvis, and pulmonary embolism (see Before you use SRT Cream). Using HRT for several years slightly increases the risk of breast cancer.
Cautions & Contraindications
Warnings & Precautions
Patients on any hormone replacement therapy (HRT) should remain under a doctor's supervision, and the same applies to the use of SRT cream. The doctor will provide ongoing advice about the risks and benefits of the medicine. Use of SRT cream should be stopped immediately if jaundice, a sudden rise in blood pressure, migraine, severe headache or pregnancy occurs. SRT cream is not for use in children.
Contraindications
Do not use Estriol cream if you have breast cancer, have ever had it, or are suspected of having it, or if you have ovarian cancer, vaginal cancer, liver disease, thrombosis, pulmonary embolism, or have had a heart attack, stroke or angina. Do not use it if you are pregnant or think you may be pregnant, or if you have any unexplained vaginal bleeding, a blood clotting disorder, endometrial hyperplasia, porphyria, or various kinds of allergic reaction, or if you have jaundice, migraine pain, high blood pressure or a breathing problem. Do not use it if you have had an allergic reaction to estriol or any of its other ingredients.
Pregnancy & Breastfeeding
Contraindicated in pregnancy and while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
If someone takes too much Estriol in one go, they may feel sick and vomit. Women may also have withdrawal bleeding. There's no specific antidote for it. If treatment is needed, the doctor treats the symptoms as they appear.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Estriol below 25°C. Protect it from light and moisture, and keep it out of reach of children.
Common questions about Ovestin 2 mg
What is Ovestin 2 mg Tablet?
Ovestin 2 mg Tablet is a medicine that contains Estriol. It is made by Nuvista Pharma PLC. It belongs to the Drugs for Infertility group of medicines.
What is Ovestin used for?
SRT cream is indicated for estrogen deficiency. During menopause, the amount of estrogen a woman's body produces gradually declines.
What are the side effects of Ovestin?
Local irritation or itching of the vagina, swelling and increased tenderness of the breasts, increased vaginal discharge, nausea, and fluid retention in the tissues (usually noticed as swollen ankles or feet) may occur. In most patients these side effects disappear after the first few weeks of treatment.
Can I take Ovestin during pregnancy or while breastfeeding?
Contraindicated in pregnancy and while breastfeeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Ovestin?
If someone takes too much Estriol in one go, they may feel sick and vomit. Women may also have withdrawal bleeding. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Ovestin?
Keep Estriol below 25°C. Protect it from light and moisture, and keep it out of reach of children.
Do I need a prescription for Ovestin?
Ovestin is a prescription (Rx) medicine. Take it as your doctor advises.