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Indications & Uses
Ovajet is indicated for:
Pharmacology
Clomiphene works mainly by blocking the effects of estrogen, though it also has some mild estrogen-like activity of its own. Exactly how it triggers ovulation isn't fully understood, but it's thought to stem from this antiestrogenic action. By competing with estrogen for binding sites in the hypothalamus, clomiphene prompts the release of more follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This rise in FSH and LH matures the ovarian follicle, brings on the LH surge that precedes ovulation, triggers ovulation itself, and supports the corpus luteum that follows. In men, its benefit for infertility is thought to work the same way, through this boost in FSH and LH.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For females: 50 mg is taken once daily for 5 days. This can begin on any day from the second to the fifth day of the menstrual cycle if bleeding is occurring, or at any time if the patient has had no recent uterine bleeding. A smaller dose or a shorter course may be needed for patients who are unusually sensitive to clomiphene, such as those with polycystic ovary syndrome. If ovulation does not occur, the dose is raised to 75-100 mg daily for 5 days, with the next course starting no sooner than 30 days after the previous one. Generally, three courses are enough to determine whether ovulation can be achieved; if it still has not occurred, the diagnosis should be reassessed. If ovulation occurs without conception, the same cycle is repeated until conception happens or for 3-4 cycles. If pregnancy has not occurred after about 6 cycles in total, continuing clomiphene therapy is not recommended.
For males: 25 mg is taken once daily for up to 90 days, with a 5-day break recommended after every 25 days of treatment.
Patients on haemodialysis: Haemodialysis shortens the serum half-life by 25-30%. Patients on regular haemodialysis are given a loading dose of 250 mg-1 g before dialysis.
Elderly: Dosing is the same as for adults.
Time to peak effect: Ovulation usually occurs 4-10 days after the last day of treatment, averaging around 7 days, though this can vary between patients and cycles. In rare cases, it may occur as late as 14 days after treatment ends.
Side Effects
At the recommended dosage, side effects are generally uncommon. How often they occur, and how severe they are, tends to depend on the dose and how long treatment lasts, and they usually resolve once clomiphene is stopped. Reported effects include visual disturbances, ovarian hyperstimulation, hot flushes, abdominal discomfort, and occasionally nausea, vomiting, depression, insomnia, breast tenderness, headache, spotting between periods, heavy menstrual bleeding, endometriosis, convulsions, weight gain, rashes, dizziness, and hair loss. Doses above 100 mg a day for five days carry a greater risk of side effects, so patients on these doses should be monitored closely. Rare cases of ovarian cancer have been reported with fertility drugs, but no causal link has been established, since infertility itself is already a major risk factor for the disease.
Cautions & Contraindications
Warnings & Precautions
Ovulet should be used only under medical supervision, with clomiphene therapy started after patients have been carefully selected. A complete pelvic examination is essential before treatment begins and must be repeated before each subsequent course, to rule out pregnancy, ovarian enlargement, or ovarian cyst formation between cycles. When conception occurs during clomiphene therapy, the chance of a multiple pregnancy is higher.
Contraindications
Clomiphene Citrate must not be used in pregnancy, liver insufficiency, or abnormal vaginal bleeding (uterine tumour, ovarian cyst).
Pregnancy & Breastfeeding
Pregnancy: Clomiphene citrate is not recommended for use during pregnancy.
Breastfeeding: When taken during breastfeeding, clomiphene citrate may reduce milk production in some women. For this reason, it is best avoided while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Clomiphene Citrate below 30°C, away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Ovajet 100 mg
What is Ovajet 100 mg Tablet?
Ovajet 100 mg Tablet is a medicine that contains Clomiphene Citrate. It is made by Drug International Unani Ltd. It belongs to the Drugs for Infertility group of medicines.
What is Ovajet used for?
Ovajet is used for: Contraception.
What are the side effects of Ovajet?
At the recommended dosage, side effects are generally uncommon. How often they occur, and how severe they are, tends to depend on the dose and how long treatment lasts, and they usually resolve once clomiphene is stopped.
Can I take Ovajet during pregnancy or while breastfeeding?
Pregnancy: Clomiphene citrate is not recommended for use during pregnancy. Breastfeeding: When taken during breastfeeding, clomiphene citrate may reduce milk production in some women. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Ovajet?
Store Clomiphene Citrate below 30°C, away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Ovajet?
Some medicines can interact with Clomiphene Citrate, for example: Follitropin Alfa. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Ovajet is already among the lowest-priced brands of Clomiphene Citrate at this strength.
Do I need a prescription for Ovajet?
Ovajet is a prescription (Rx) medicine. Take it as your doctor advises.