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Doctors prescribe the Dexamethasone + Neomycin + Glacial Acetic Acid ear spray for otitis externa.
Pharmacology
Neomycin sulfate is an established antibiotic, and its range of activity against bacteria is broad and well characterised. Dexamethasone is a well established steroid used on the skin or in the ear to reduce inflammation. Acetic acid works by making the area more acidic (a low pH), which helps control bacterial infection.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults, including the elderly, and children aged 2 years and over should use one metered dose (60 mg) directly in each affected ear, three times a day. Keep going until two days after the symptoms have gone. If there is no clinical improvement after 7 days, stop the treatment.
This ear spray is not suitable for infants and neonates (under 2 years of age).
Shake the bottle well before use. Before the first use, press the actuator down several times to get a fine spray. After that, each press gives one metered dose. Do not inhale the spray. Gently place the nozzle tip into the ear opening and press the actuator down once. Use the bottle within one month of first use. If more than one week has passed since the last use, press the actuator down a few times before using it again.
Side Effects
Eye disorders Blurred vision has been reported with corticosteroid use. For dexamethasone, how often this happens is not known. Skin and subcutaneous tissue disorders Some patients may feel a brief stinging or burning sensation during the first few days of treatment. Skin hypersensitivity reactions, both immediate and delayed, can also occur. These lead to irritation, burning, stinging, itching and dermatitis. Reporting of suspected adverse reactions Reporting suspected adverse reactions after the medicinal product has been authorised is important. It allows the benefit/risk balance of the medicinal product to be monitored on a continuing basis.
Cautions & Contraindications
Warnings & Precautions
Stop using this Dexamethasone + Neomycin + Glacial Acetic Acid product, and seek medical advice where appropriate, if irritation or rash occurs, or if the condition gets worse or does not improve within 7 days. When otitis externa is treated topically with a preparation containing an aminoglycoside, a patient with a perforated tympanic membrane has a higher risk of drug induced deafness. So check that there is no perforation in these patients. Other chronic diagnoses, including chronic otitis media, should be ruled out before treatment begins. Corticosteroid/antibiotic combinations should not be continued for more than 7 days if there is no clinical improvement, because prolonged use may lead to occult extension of infections, since the steroid masks them. In children there is a theoretical risk that enough steroid may be absorbed to cause adrenal suppression, and longer use increases that risk. Prolonged use may also lead to skin sensitisation and the emergence of resistant organisms. Children may have immature renal function, so toxicity can develop, and caution is needed when giving neomycin in this age group. Aminoglycoside antibiotics may cause irreversible, partial or total deafness when given systemically or when applied topically to open wounds or damaged skin. This effect is dose related and is made worse by renal or hepatic impairment. The possibility should be considered when high doses or prolonged treatment are given to small children.
Contraindications
Don't use this ear drop if you are allergic to dexamethasone, neomycin, glacial acetic acid or any of the other ingredients in it. It should also not be used when the eardrum (tympanic membrane) is known or suspected to be perforated, or when a tympanostomy tube (grommet) is in place. Infants and neonates under 2 years of age should not be given this medicine.
Pregnancy & Breastfeeding
Pregnancy
There aren't enough data on the use of dexamethasone in pregnant women. Animal studies have shown that corticosteroids applied to the skin can cause reproductive toxicity. Aminoglycoside antibiotic preparations also carry a risk of foetal ototoxicity if they are given during pregnancy. This ear spray is not recommended during pregnancy.
Lactation
No reports are available on the use of neomycin or dexamethasone during human breast-feeding, so the effects on a nursing infant from the medicine in milk are unknown. Topical preparations used by the mother generally carry less risk than a medicine given systemically. Even so, a risk to the breast-fed child cannot be excluded. A decision has to be made either to stop breast-feeding or to stop or avoid treatment with this ear spray, weighing the benefit of breast-feeding for the child against the benefit of treatment for the woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store below 25ºC and don't freeze it. Keep the container upright in its outer carton. Use it within one month of first opening.
Common questions about Otomix 0.1% + 0.5% + 2%
What is Otomix 0.1% + 0.5% + 2% Topical Spray?
Otomix 0.1% + 0.5% + 2% Topical Spray is a medicine that contains Dexamethasone + Neomycin + Glacial Acetic Acid. It is made by Opsonin Pharma Limited. It belongs to the Anti-infectives & antiseptics group of medicines.
What is Otomix used for?
Doctors prescribe the Dexamethasone + Neomycin + Glacial Acetic Acid ear spray for otitis externa.
What are the side effects of Otomix?
Eye disorders Blurred vision has been reported with corticosteroid use. For dexamethasone, how often this happens is not known.
Can I take Otomix during pregnancy or while breastfeeding?
Pregnancy There aren't enough data on the use of dexamethasone in pregnant women. Animal studies have shown that corticosteroids applied to the skin can cause reproductive toxicity. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Otomix?
Store below 25ºC and don't freeze it. Keep the container upright in its outer carton.
Do I need a prescription for Otomix?
Otomix is a prescription (Rx) medicine. Take it as your doctor advises.