Ostel-D 70/2800
Rx70 mg • Tablet
Indications & Uses
Ostel-D 70/2800 is indicated for:
Pharmacology
Alendronate sodium belongs to the bisphosphonate class and works by specifically inhibiting osteoclast-mediated bone resorption. To be effective, it should be taken at least 30 minutes before breakfast. After administration, it briefly distributes into soft tissues before being rapidly taken up by bone or excreted in the urine, and it is roughly 78% bound to plasma proteins. There is no evidence that it is metabolised in either animals or humans.
At the cellular level, Alendronate concentrates preferentially at sites of bone resorption, particularly beneath osteoclasts, where it suppresses their activity. As a result, bone formation comes to outpace bone resorption, producing a progressive increase in bone mass.
Vitamin D, for its part, is essential for normal bone formation. When both sunlight exposure and dietary intake fall short, Vitamin D insufficiency can develop, and this is linked to a negative calcium balance, raised parathyroid hormone levels, bone loss, and a greater risk of fracture.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage for Treatment of Osteoporosis in Postmenopausal Women: The recommended dose is 70 mg alendronate combined with either 2800 IU or 5600 IU of vitamin D3, taken as one tablet once weekly. For most women with osteoporosis, the 70 mg alendronate and 5600 IU vitamin D3 combination is the appropriate choice.
Dosage to Increase Bone Mass in Men with Osteoporosis: The recommended dose is 70 mg alendronate combined with either 2800 IU or 5600 IU of vitamin D3, taken as one tablet once weekly. For most men with osteoporosis, the 70 mg alendronate and 5600 IU vitamin D3 combination is the appropriate choice.
Side Effects
Usually mild and rarely severe enough to require stopping treatment. Reported effects include reactions in the food pipe (oesophagus), abdominal pain and bloating, diarrhoea or constipation, gas, muscle or joint pain, headache, skin rash, and redness of the skin, along with temporary drops in blood calcium and phosphate levels.
Cautions & Contraindications
Warnings & Precautions
Hypocalcaemia and any other disturbances of mineral metabolism should be corrected before starting treatment. Alendronate can irritate the lining of the upper gastrointestinal tract, so it should be used with caution in patients who already have upper GI problems such as difficulty swallowing, esophageal disease, gastritis, duodenitis, or ulcers. Patients should stop taking the medicine and consult their physician if they develop symptoms of esophageal disease.
Contraindications
Abnormalities of the esophagus that slow its emptying, such as stricture or achalasia. Inability to remain upright (sitting or standing) for at least 30 minutes. Known hypersensitivity to any ingredient in this product. Low blood calcium levels (hypocalcaemia).
Pregnancy & Breastfeeding
Pregnancy category C. In animal studies, very high doses of vitamin D caused birth defects, so Alendronic Acid & Vitamin D3 (Colecalciferol) should be used during pregnancy only if the expected benefit to the mother outweighs the possible risk to her and the unborn baby. Cholecalciferol and some of its active breakdown products pass into breast milk, and it is not known whether alendronate does as well. This combination should therefore be used with caution in breastfeeding mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Alendronic Acid + Vitamin D3 (Colecalciferol) needs no dose change in elderly patients. The same is true for patients with mild-to-moderate renal insufficiency, meaning a creatinine clearance of 35 to 60 mL/min.
It is not recommended for patients with more severe renal insufficiency, where creatinine clearance is below 35 mL/min, because there is a lack of experience in this group.
Overdose
If too much Alendronic Acid + Vitamin D3 is taken by mouth, it may cause low blood calcium (hypocalcemia) and low blood phosphate (hypophosphatemia). Upper gastrointestinal problems can also follow, such as upset stomach, heartburn, esophagitis, gastritis or ulcer.
Vitamin D toxicity shows up as high blood calcium (hypercalcemia) and high calcium in the urine (hypercalciuria). Other signs are loss of appetite, nausea, vomiting, passing a lot of urine (polyuria), excessive thirst (polydipsia), weakness and lethargy.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Drug Interactions
Common questions about Ostel-D 70/2800 70 mg
What is Ostel-D 70/2800 70 mg Tablet?
Ostel-D 70/2800 70 mg Tablet is a medicine that contains Alendronic Acid + Vitamin D3. It is made by Square Pharmaceuticals PLC, Gazipur. It belongs to the Combined preparations: Inhibiting bone resorption group of medicines.
What is Ostel-D 70/2800 used for?
Ostel-D 70/2800 is used for: Osteoporosis.
What are the side effects of Ostel-D 70/2800?
Usually mild and rarely severe enough to require stopping treatment. Reported effects include reactions in the food pipe (oesophagus), abdominal pain and bloating, diarrhoea or constipation, gas, muscle or joint pain, headache, skin rash, and redness of the skin, along with temporary drops in blood calcium and phosphate levels.
Can I take Ostel-D 70/2800 during pregnancy or while breastfeeding?
Pregnancy category C. In animal studies, very high doses of vitamin D caused birth defects, so Alendronic Acid & Vitamin D3 (Colecalciferol) should be used during pregnancy only if the expected benefit to the mother outweighs the possible risk to her and the unborn baby. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Ostel-D 70/2800?
If too much Alendronic Acid + Vitamin D3 is taken by mouth, it may cause low blood calcium (hypocalcemia) and low blood phosphate (hypophosphatemia). Upper gastrointestinal problems can also follow, such as upset stomach, heartburn, esophagitis, gastritis or ulcer. In an emergency call 999 or go to the nearest hospital emergency department.
Can I take other medicines with Ostel-D 70/2800?
Some medicines can interact with Alendronic Acid + Vitamin D3, for example: Aspirin, Cimetidine, Cholestyramine, Orlistat, Ranitidine. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Ostel-D 70/2800?
Ostel-D 70/2800 is a prescription (Rx) medicine. Take it as your doctor advises.