Pricing
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Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The adult dose of Mannitol ranges from 50 to 100 gm by IV infusion. The rate of administration is usually adjusted to maintain a urine flow of at least 30 to 50 ml/hr. Total dosage, concentration and the rate of administration depends on fluid requirement, urinary output and the severity of the condition being treated.
For renal insufficiency, adults are given 50 to 100 g of Mannitol at a rate adjusted to maintain a urine flow of at least 30 to 50 ml/hr, while children are given 2 gm/kg or 60 gm/m2 of body surface area over a period of 2 to 6 hrs.
For cerebral edema, elevated intracranial pressure, elevated intraocular pressure and glaucoma, adults are given 1.5 to 2 gm/kg over a period of 30 to 60 minutes, while children are given 1 to 2 gm/kg body wt. or 30 to 60 gm/m2 of body surface area over a period of 30 to 60 mins.
As adjunctive therapy for removal of toxic substances, adults are given 50 to 200 g of Mannitol at a rate adjusted to maintain a urine flow of at least 100 to 500 ml/hr, while children are given 2 gm/kg or 60 gm/m2 of body surface area.
For termination of pregnancy, 50 gm of Mannitol (250 ml of Mannitol) is instilled into the amniotic cavity, which induces abortion in a high proportion of pregnancies.
Side Effects
Osmotic intravenous infusions such as this one most commonly cause fluid and electrolyte imbalances, which at high doses can include circulatory overload and acidosis. Other reported side effects are nausea, vomiting, thirst, headache, dizziness, fever, a fast heartbeat, chest pain, low blood sodium, dehydration, blurred vision, hives, and either high or low blood pressure.
Cautions & Contraindications
Warnings & Precautions
The rate at which Osmotic is given needs to be watched closely, so that fluid and electrolyte imbalance and circulatory overloading don't develop. Stop the infusion if the patient shows signs of progressive renal dysfunction, heart failure or pulmonary congestion. Osmotic should not be given together with whole blood. If rigor starts at any point during the infusion, whatever the cause, stop the fluid immediately. Don't use the solution if it looks cloudy or has particles in it, or if the expiry date has passed.
Contraindications
Mannitol intravenous infusion should not be used in patients with pulmonary edema or congestive heart failure. It should also be avoided when urine flow is inadequate, in cases of dehydration or acidosis, in intracranial bleeding, and in patients with renal failure unless a test dose has produced a diuretic response.
Pregnancy & Breastfeeding
Safety of intravenous Mannitol during pregnancy has not been established. It is also not known whether mannitol passes into breast milk, so it should be used only after carefully weighing the potential benefits against the possible risks.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Mannitol at a temperature of 20° to 30°. If it gets exposed to lower temperatures, crystals may settle out of the solution. You can dissolve them by warming the bottle in hot water for about 30 minutes, and then the solution must cool to body temperature before use. If every crystal can't be dissolved, don't use the solution.
Once a container has been opened, use its contents promptly. Throw away whatever is left unused.
Common questions about Osmosol 20%
What is Osmosol 20% IV Infusion?
Osmosol 20% IV Infusion is a medicine that contains Mannitol. It is made by Beximco Pharmaceuticals Ltd. It belongs to the Osmotic diuretics group of medicines.
What is Osmosol used for?
Osmosol is used for: Glaucoma, Edema.
What are the side effects of Osmosol?
Osmotic intravenous infusions such as this one most commonly cause fluid and electrolyte imbalances, which at high doses can include circulatory overload and acidosis. Other reported side effects are nausea, vomiting, thirst, headache, dizziness, fever, a fast heartbeat, chest pain, low blood sodium, dehydration, blurred vision, hives, and either high or low blood pressure.
Can I take Osmosol during pregnancy or while breastfeeding?
Safety of intravenous Mannitol during pregnancy has not been established. It is also not known whether mannitol passes into breast milk, so it should be used only after carefully weighing the potential benefits against the possible risks. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Osmosol?
Keep Mannitol at a temperature of 20° to 30°. If it gets exposed to lower temperatures, crystals may settle out of the solution.
Do I need a prescription for Osmosol?
Osmosol is a prescription (Rx) medicine. Take it as your doctor advises.